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10june 2015: http://journals.plos.org/plosone/art...l.pone.0129578
"These results demonstrate that topical oleuroepin administration induced anagenic hair growth in telogenic C57BL/6N mouse skin. The hair-growth promoting effect of oleuropein in mice appeared to be associated with the stimulation of the Wnt10b/β-catenin signaling pathway and the upregulation of IGF-1, KGF, HGF, and VEGF gene expression in mouse skin tissue."
I think SAMUMED and their Wnt pathway modulating molecule will be our man.
When I read again things like this:
-"A new study, published in Cell Stem Cell, identifies a molecular pathway that can be activated to prompt hair growth of dormant hair follicles.
Conversely, if delivered in a limited, safe and controlled way, agents that activate Wnt signaling might be used to promote hair growth in dormant hair follicles in conditions such as male pattern baldness,” said senior author Sarah Millar, PhD,"
Don't SM could be the molecule that Follica's team need after their skin wounding procedure to help to induce hair follicle regeneration?
-“We have at last made a connection between Wnt signaling and human hair disease that is highly significant,”“Furthermore, these findings suggest that manipulating the Wnt pathway may have an effect on hair follicle growth — for the first time, in humans,” said Dr. Christiano.
-"Macrophages secrete a number of factors including a class of signaling molecules called Wnts. Importantly, when the researchers treated macrophages with a Wnt inhibitor drug, the activation of hair growth was delayed—demonstrating a role for Wnt from macrophages in promoting hair growth. Although this study was carried out in mice, the researchers believe their discovery "may facilitate the development of novel treatment strategies" for hair growth in humans. Spanish team
Since SAMUMED is specialize in Wnt pathway, and focus only on that domain, I suspect they already have all the keys in hands to give us a terrific effective drug. Who's with me? x)
Two other things that made me believe in them, is the enrollment of 300 people for phase 2, and that they are an important sponsor/exhibitor for 2015 hair congress.
I hope they will give phase 2 results during that congress
"These results demonstrate that topical oleuroepin administration induced anagenic hair growth in telogenic C57BL/6N mouse skin. The hair-growth promoting effect of oleuropein in mice appeared to be associated with the stimulation of the Wnt10b/β-catenin signaling pathway and the upregulation of IGF-1, KGF, HGF, and VEGF gene expression in mouse skin tissue."
I think SAMUMED and their Wnt pathway modulating molecule will be our man.
When I read again things like this:
-"A new study, published in Cell Stem Cell, identifies a molecular pathway that can be activated to prompt hair growth of dormant hair follicles.
Conversely, if delivered in a limited, safe and controlled way, agents that activate Wnt signaling might be used to promote hair growth in dormant hair follicles in conditions such as male pattern baldness,” said senior author Sarah Millar, PhD,"
Don't SM could be the molecule that Follica's team need after their skin wounding procedure to help to induce hair follicle regeneration?
-“We have at last made a connection between Wnt signaling and human hair disease that is highly significant,”“Furthermore, these findings suggest that manipulating the Wnt pathway may have an effect on hair follicle growth — for the first time, in humans,” said Dr. Christiano.
-"Macrophages secrete a number of factors including a class of signaling molecules called Wnts. Importantly, when the researchers treated macrophages with a Wnt inhibitor drug, the activation of hair growth was delayed—demonstrating a role for Wnt from macrophages in promoting hair growth. Although this study was carried out in mice, the researchers believe their discovery "may facilitate the development of novel treatment strategies" for hair growth in humans. Spanish team
Since SAMUMED is specialize in Wnt pathway, and focus only on that domain, I suspect they already have all the keys in hands to give us a terrific effective drug. Who's with me? x)
Two other things that made me believe in them, is the enrollment of 300 people for phase 2, and that they are an important sponsor/exhibitor for 2015 hair congress.
I hope they will give phase 2 results during that congress
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