Summer cutting edge treatments update: 2015

[joachim]

The procedure is way more invasive than anybody seems to admit.

That said, if there is regeneration-- then yes it is a game changer. Otherwise it's just another option.

needhairasap: could you please give me a link to the full study of the recent DP characteristics improvement with wnt1a? (the study you posted on other forums). maybe even make a new thread for it. i think that's a big deal. would like to go through the whole study to see if they finally cracked that last puzzle to multiply the DP cells in masses and restoring all their chracteristics. jahoda, christiano and others failed at that point. if that new study tells us that it's finally possible now, then the cure is not far off. give us more infos on that please. thank you!
if it turns out they really succeeded with consistent DP multiplication in vitro, then we have to throw that information to jahoda, christiano, taiwan university, and others.

[It's2014ComeOnAlready]

CB will be released if prostaglandin theory ends up falling. 5 years isn't out of a hat. If SM is successful they will start phase III at best case scenario 1 year from now, that will last a year then we got about another year for FDA approval. That's 3+ years already, and it's the closest thing to market right now other than bim, but I don't see why Bim would not be in phase III a year after phase IIb was completed if it had been successful.

From some of the reading I've done, it doesn't seem that the 21 century cures act will benefit drugs like these, at least for coming years. Yes, I agree it will be passed, but I don't think it will affect any of these drugs, at least initially. The CEO of allergen actually stated that the soonest we will see Bim, if ever, would be 2019..those words are out of his mouth, not mine, unfortunately.

1. Very doubtful the prostaglandin theory fails. 2 different companies were both willing to take on the cost to trial a drug for hair loss (which is very risky, since most have failed), after 2 years of preclinical research. Both claimed they were very impressed with the science. More than likely, they have the data to back this up.

2. Saying that SM will start their phase 3, if phase 2 was successful, in July 2016, when phase 2 is up in October literally makes no sense. There was a very quick turnaround between phase 1 and the massive 300 participant phase 2, of only 3 months. If successful, they could take the recruits they already had for phase 2 (300) and continue.

3. Bim, perhaps needed another drug like Seti to complement it, and for them to want to move forward.

4. The 21st century cures act becomes law within 10 days of being signed, and the modernization of clinical trials is generally applicable. Yes, cancer drugs etc will take precedent and get approval maybe after phase 2, but this bill is an overhaul to change the way clinical trials are carried out. They are applying the law to the process of discovery, development, and delivery, and not just for certain drugs. Otherwise, the law would be favoring certain companies and certain drugs only.

5. That "2019" quote is here: http://www.reuters.com/article/2013/...9400UW20130501

It refers to Darpin, not Bimatoprost. Whoever's been spreading that, misread the quote, and ran with it.

[FearTheLoss]

Reality? You pulled that 5 years out of a hat. If SM is successful, it won't take 5 years for a phase 3 and release. SM is 11 months for phase 3, and 10 months maximum for FDA approval. If bim is successful, it won't take 3 years for a phase 3 and release. Bim is 1 year phase 3, + 10 months max for FDA approval. CB is never going to get released as a topical, you have to apply 2X a day, and is scheduled to be out in 6 years.

I know a lot of people here don't put stock into the 21st Century Cures Act, but when a bill that's transformative as this, and gets a unanimous 51-0 vote in the Energy and Commerce House committee. Then, goes on to get the majority of Congress of both dems and repubs to cosponsor the bill. Also is likely to get the overwhelming majority of House votes (350+), to send a strong message to the senate. I've read many articles that they firmly believe it will be signed into law before the year is out. This would cut a lot of that time down, because they will be measuring results in trials via biomarkers and surrogate endpoints.

CB will be released if prostaglandin theory ends up falling. 5 years isn't out of a hat. If SM is successful they will start phase III at best case scenario 1 year from now, that will last a year then we got about another year for FDA approval. That's 3+ years already, and it's the closest thing to market right now other than bim, but I don't see why Bim would not be in phase III a year after phase IIb was completed if it had been successful.

From some of the reading I've done, it doesn't seem that the 21 century cures act will benefit drugs like these, at least for coming years. Yes, I agree it will be passed, but I don't think it will affect any of these drugs, at least initially. The CEO of allergen actually stated that the soonest we will see Bim, if ever, would be 2019..those words are out of his mouth, not mine, unfortunately.

[TubZy]

What is the issue with bim right now?

I have a custom order from TLR that I will be trying out. It is .03% of bim in ethanol. I will be applying 3 or more milliliters every night

[It's2014ComeOnAlready]

All I'm saying about the bill, is that it has enough political will to become law. Politics have been extremely divided in recent memory, but on this they seem to agree.

"The legislation has also received letters of support from hundreds of organizations, including patient groups, the Association of American Medical Colleges, sixty-seven cancer institutes, and seventy-five research, life sciences, and patient advocacy organizations."

[lacazette]

I want new treatments just as bad as you and the rest of the lot, but that's reality.

CB is finishing phase II poc, then dose ranging then phase III and then release and they are projecting for 2021. The only thing ahead of them is SM, which we have no idea if it will work at all, and Bim, which we know works to an extent, but it's a little fishy they haven't announced results or began phase III. Granted, that fishiness is speculation, and I think pgd2/pge2 may have some great merit, we will have to wait to see. If they were successful, we could see Bim in 3 years

You don't take in consideration the "21st century cure" bill that could help us to have something hit the market sooner.

And you don't talk about regenerative medecine and Stem cells treatments in japan.
Look at their approval timeline : http://www.google.fr/imgres?imgurl=h...ed=0CCEQrQMwAA

All stem cell research domain will grow fast there, Japan will become the 'place to be' for company and researchers. All the progress that will be made in technology, knowledge, etc.. regarding stem cells will benefit hair loss domain.
Histogen and replicel/sisheido could be the firsts, or just the ones we are awared of, but competition will bring us new pretendants.
When you add japanese society's mentality regarding professionalism, I really think the future is there for our best hope. They are in advance and their new laws in 2014 about regenerative medecine proove it

[NeedHairASAP]

"Not seeing what is interesting about pilocopy"

I don't agree man it's just a 2cm scar and you can take hairs without any other scars in the skin. And the graft survival rate is better.
Even a Norwood 6 could over harvest the donor area to put on the top, and make smp on sides and back.
let grow on top, and shaves the sides/back. Ok it's not the perfect solution, but even big Norwood could have a decent hair cut with density on top. I prefer have this one option hair cut, than a horseshoe , not you?
And even for normal HT, it's more pleasant than fue, it's better to have a 2cm scar than thousands white dots and the impossibility to shave.

The procedure is way more invasive than anybody seems to admit.

That said, if there is regeneration-- then yes it is a game changer. Otherwise it's just another option.

[It's2014ComeOnAlready]

I want new treatments just as bad as you and the rest of the lot, but that's reality.

CB is finishing phase II poc, then dose ranging then phase III and then release and they are projecting for 2021. The only thing ahead of them is SM, which we have no idea if it will work at all, and Bim, which we know works to an extent, but it's a little fishy they haven't announced results or began phase III. Granted, that fishiness is speculation, and I think pgd2/pge2 may have some great merit, we will have to wait to see. If they were successful, we could see Bim in 3 years

Reality? You pulled that 5 years out of a hat. If SM is successful, it won't take 5 years for a phase 3 and release. SM is 11 months for phase 3, and 10 months maximum for FDA approval. If bim is successful, it won't take 3 years for a phase 3 and release. Bim is 1 year phase 3, + 10 months max for FDA approval. CB is never going to get released as a topical, you have to apply 2X a day, and is scheduled to be out in 6 years.

I know a lot of people here don't put stock into the 21st Century Cures Act, but when a bill that's transformative as this, and gets a unanimous 51-0 vote in the Energy and Commerce House committee. Then, goes on to get the majority of Congress of both dems and repubs to cosponsor the bill. Also is likely to get the overwhelming majority of House votes (350+), to send a strong message to the senate. I've read many articles that they firmly believe it will be signed into law before the year is out. This would cut a lot of that time down, because they will be measuring results in trials via biomarkers and surrogate endpoints.

[FearTheLoss]

5 years? lol, c'mon dude

I want new treatments just as bad as you and the rest of the lot, but that's reality.

CB is finishing phase II poc, then dose ranging then phase III and then release and they are projecting for 2021. The only thing ahead of them is SM, which we have no idea if it will work at all, and Bim, which we know works to an extent, but it's a little fishy they haven't announced results or began phase III. Granted, that fishiness is speculation, and I think pgd2/pge2 may have some great merit, we will have to wait to see. If they were successful, we could see Bim in 3 years

[Slam1523]

I know the time frames are ridiculous, but can the cliche chime in of, "lol 5-10 years away!" please be dead? We all get it, but I literally can't stomach the thought of that awful attempt at humor anymore!

[Seuxin]

CB in 2021???? Really ???
I thought it was 2018.....

[tedwuji]

"Not seeing what is interesting about pilocopy"

I don't agree man it's just a 2cm scar and you can take hairs without any other scars in the skin. And the graft survival rate is better.
Even a Norwood 6 could over harvest the donor area to put on the top, and make smp on sides and back.
let grow on top, and shaves the sides/back. Ok it's not the perfect solution, but even big Norwood could have a decent hair cut with density on top. I prefer have this one option hair cut, than a horseshoe , not you?
And even for normal HT, it's more pleasant than fue, it's better to have a 2cm scar than thousands white dots and the impossibility to shave.

yes i agree. PiloFocus would be revolutionary in the simple fact theres no scar. even if u continue to bald u dont lose the option to shave your head. that is a huge benefit and peace of mind. regeneration aside. no scar alone is something to get excited about, for me.

[lacazette]

"Not seeing what is interesting about pilocopy"

I don't agree man it's just a 2cm scar and you can take hairs without any other scars in the skin. And the graft survival rate is better.
Even a Norwood 6 could over harvest the donor area to put on the top, and make smp on sides and back.
let grow on top, and shaves the sides/back. Ok it's not the perfect solution, but even big Norwood could have a decent hair cut with density on top. I prefer have this one option hair cut, than a horseshoe , not you?
And even for normal HT, it's more pleasant than fue, it's better to have a 2cm scar than thousands white dots and the impossibility to shave.

[Keki]

Thanks for the update. So what would be the ideal most effective stack now for halting, regrowth and thickness?

OC
low dose RU (20 or 30mg)
neogenic
adenogen

this is the "extremely expensive" way to halt you hairloss not the most effective one, we don't have any experience with oc, ru it's the same thing as fina but without control on source, neogenic does very little so adenogen which is less effective then minox anyway and 4x more expensive, but at least doesn't seems to give shedding

[lacazette]

I really believe in SAMUMED
Their other molecule in trial is for patient with final phase of differents cancers
They work on powerful drugs, and that ' Wnt pathway modulating' is really interesting.
The phase 2 took 11 months, started Nov.2014 and final data is in October 2015. If they get good results and they do the same trial timeline for phase 3 with larger populations, that sounds good