Stem Cells cured AA

Collapse
X
Collapse
 
  • Page of 2
  • Time
  • Show
Clear All
new posts
Previous 1 2 template Next
  • TooMuchHairWontKillYou
    Senior Member
    • Apr 2015
    • 104
    #1

    Stem Cells cured AA

    I read this thread on *** forum.
    Hair regrowth in alopecia areata patients following Stem Cell Educator therapy - BMC Medicine
    http://www.biomedcentral.com/1741-7015/13/87
    Background Alopecia areata (AA) is one of the most common autoimmune diseases and targets the hair follicles, with high impact on the quality of life and self-esteem of patients due to hair loss. Clinical management and outcomes are challenged by current limited immunosuppressive and immunomodulating regimens. Methods We have developed a Stem Cell Educator therapy in which a patient’s blood is circulated through a closed-loop system that separates mononuclear cells from the whole blood, allows the cells to briefly interact with adherent human cord blood-derived multipotent stem cells (CB-SC), and returns the “educated” autologous cells to the patient’s circulation. In an open-label, phase 1/phase 2 study, patients (N = 9) with severe AA received one treatment with the Stem Cell Educator therapy. The median age was 20 years (median alopecic duration, 5 years). Results Clinical data demonstrated that patients with severe AA achieved improved hair regrowth and quality of life after receiving Stem Cell Educator therapy. Flow cytometry revealed the up-regulation of Th2 cytokines and restoration of balancing Th1/Th2/Th3 cytokine production in the peripheral blood of AA subjects. Immunohistochemistry indicated the formation of a “ring of transforming growth factor beta 1 (TGF-β1)” around the hair follicles, leading to the restoration of immune privilege of hair follicles and the protection of newly generated hair follicles against autoimmune destruction. Mechanistic studies revealed that co-culture with CB-SC may up-regulate the expression of coinhibitory molecules B and T lymphocyte attenuator (BTLA) and programmed death-1 receptor (PD-1) on CD8β+NKG2D+ effector T cells and suppress their proliferation via herpesvirus entry mediator (HVEM) ligands and programmed death-1 ligand (PD-L1) on CB-SCs. Conclusions Current clinical data demonstrated the safety and efficacy of the Stem Cell Educator therapy for the treatment of AA. This innovative approach produced lasting improvement in hair regrowth in subjects with moderate or severe AA. Trial registration ClinicalTrials.gov, NCT01673789 , 21 August 2012



    Very interesting research with cure for AA.
    What do you think guy does it have potential against AGA? I am not so educated in this matter :\

    I sent email to that researcher but got no replies.
    Tags: None
    • robincurtz
      Senior Member
      • Jan 2015
      • 225
      #2
      Wow

        Comment

        • jamesst11
          Senior Member
          • Jun 2014
          • 1067
          #3
          AA has a very specific physiological trigger that they have essentially found a cure for, but even that comes with very risky side effects. AGA has completely different and infinitely more difficult mechanisms.

            Comment

            • It's2014ComeOnAlready
              Senior Member
              • Sep 2014
              • 584
              #4
              Pretty awesome. Good for her, and anyone dealing with AA.

                Comment

                • TooMuchHairWontKillYou
                  Senior Member
                  • Apr 2015
                  • 104
                  #5
                  Originally posted by It's2014ComeOnAlready
                  Pretty awesome. Good for her, and anyone dealing with AA.
                  Its moore than "pretty awesome" for them

                    Comment

                    • Trouse5858
                      Senior Member
                      • Apr 2014
                      • 166
                      #6
                      Originally posted by jamesst11
                      AA has a very specific physiological trigger that they have essentially found a cure for, but even that comes with very risky side effects. AGA has completely different and infinitely more difficult mechanisms.
                      Hadn't heard of this? Would you mind elaborating on the side effects for the treatment this woman had? I couldn't find much on Google

                        Comment

                        • TooMuchHairWontKillYou
                          Senior Member
                          • Apr 2015
                          • 104
                          #7
                          Originally posted by Trouse5858
                          Hadn't heard of this? Would you mind elaborating on the side effects for the treatment this woman had? I couldn't find much on Google
                          This is a full study. Everything should be here.

                          Hair regrowth in alopecia areata patients following Stem Cell Educator therapy - BMC Medicine
                          http://www.biomedcentral.com/1741-7015/13/87
                          Background Alopecia areata (AA) is one of the most common autoimmune diseases and targets the hair follicles, with high impact on the quality of life and self-esteem of patients due to hair loss. Clinical management and outcomes are challenged by current limited immunosuppressive and immunomodulating regimens. Methods We have developed a Stem Cell Educator therapy in which a patient’s blood is circulated through a closed-loop system that separates mononuclear cells from the whole blood, allows the cells to briefly interact with adherent human cord blood-derived multipotent stem cells (CB-SC), and returns the “educated” autologous cells to the patient’s circulation. In an open-label, phase 1/phase 2 study, patients (N = 9) with severe AA received one treatment with the Stem Cell Educator therapy. The median age was 20 years (median alopecic duration, 5 years). Results Clinical data demonstrated that patients with severe AA achieved improved hair regrowth and quality of life after receiving Stem Cell Educator therapy. Flow cytometry revealed the up-regulation of Th2 cytokines and restoration of balancing Th1/Th2/Th3 cytokine production in the peripheral blood of AA subjects. Immunohistochemistry indicated the formation of a “ring of transforming growth factor beta 1 (TGF-β1)” around the hair follicles, leading to the restoration of immune privilege of hair follicles and the protection of newly generated hair follicles against autoimmune destruction. Mechanistic studies revealed that co-culture with CB-SC may up-regulate the expression of coinhibitory molecules B and T lymphocyte attenuator (BTLA) and programmed death-1 receptor (PD-1) on CD8β+NKG2D+ effector T cells and suppress their proliferation via herpesvirus entry mediator (HVEM) ligands and programmed death-1 ligand (PD-L1) on CB-SCs. Conclusions Current clinical data demonstrated the safety and efficacy of the Stem Cell Educator therapy for the treatment of AA. This innovative approach produced lasting improvement in hair regrowth in subjects with moderate or severe AA. Trial registration ClinicalTrials.gov, NCT01673789 , 21 August 2012

                            Comment

                            • joachim
                              Senior Member
                              • May 2014
                              • 559
                              #8
                              although we know that AA is probably a very different mechanism compared to AGA it still must be the case that those drugs or stem cell treatments start triggering a lot of growth factors releases or so, otherwise this boost in hair growth can't be explained. there are positive effects from this on the hair follicles in general, so I see a good chance this could have a good effect for MPB too. however, nobody will try this out for MPB, so we will never know. that's the big problem with all the recent treatments against AA which popped up in the recent months.

                                Comment

                                • HairlossAt15
                                  Member
                                  • May 2013
                                  • 91
                                  #9
                                  In AA hair follicle stem cells are maintained just like in AGA. Seeing a patient get so much regrowth really puts a smile on my face that the same can possibly be done with AGA

                                    Comment

                                    • hellouser
                                      Senior Member
                                      • May 2012
                                      • 4419
                                      #10
                                      So, the 95% of hair loss sufferers which are AGA sufferers, get snubbed once again huh? Cool. Nice to see the priorities of researchers are in check.

                                        Comment

                                        • Trouse5858
                                          Senior Member
                                          • Apr 2014
                                          • 166
                                          #11
                                          Originally posted by hellouser
                                          So, the 95% of hair loss sufferers which are AGA sufferers, get snubbed once again huh? Cool. Nice to see the priorities of researchers are in check.
                                          lol I don't think that's really an accurate representation of how this 'cure' unfolded. From what I've read, it seems like they simply got lucky and stumbled upon it because the science isn't overly complex. There's just no way that AA treatments receive more funding than their AGA counterparts.

                                            Comment

                                            • Swooping
                                              Senior Member
                                              • May 2014
                                              • 794
                                              #12
                                              Damn from almost complete baldness to a luxurious head full of shining hair how awesome .

                                                Comment

                                                • just2hairs
                                                  Member
                                                  • Mar 2015
                                                  • 39
                                                  #13
                                                  AA vs AGA

                                                  Can someone please tell me how to know for sure if what i have it AA vs AGA? I have thinning all over, even on the sides and back. I've been to the doctor 3x and he never even mentioned AA. He just gives me propecia and recommended minoxdil and send me on my way.

                                                  My blood works come out normal. Is there maybe a test to say if it's mbp or AA?

                                                    Comment

                                                    • Hemo
                                                      Senior Member
                                                      • Apr 2015
                                                      • 138
                                                      #14
                                                      How significantly different are your sides thinning compared to the top, if at all? I think AGA often present earlier in life, so you likely would have started to lose hair (even if just a patch) at an age when MPB wasn't normal (but don't quote me on that). I'm sure there is a blood/other test to determine but it sounds like you'll have to go to someone other than your derm to diagnose.

                                                        Comment

                                                        • DepressedByHairLoss
                                                          Senior Member
                                                          • Feb 2011
                                                          • 854
                                                          #15
                                                          Originally posted by Trouse5858
                                                          lol I don't think that's really an accurate representation of how this 'cure' unfolded. From what I've read, it seems like they simply got lucky and stumbled upon it because the science isn't overly complex. There's just no way that AA treatments receive more funding than their AGA counterparts.
                                                          Logically you wouldn't think so, but new treatments for AA are sprouting up all over the place: from this study to Xeljanz to prednisone to steroid growth treatments. Yet what do AGA sufferers currently have? The same limited and mediocre sh*t as 17 years ago: minoxidil, finasteride, and hair transplants.

                                                            Comment

                                                            Previous 1 2 template Next
                                                            Working...