Is there any chance to recover our hair in 5 years?

[barfacan]

I think even if we get a finasteride-equivalent (WITHOUT any side effects) within the next 5 years, that would be a huge success

[Swooping]

No.

You are a NW3 though assuming you can maintain your hair and have good hair characteristics you can get a HT and call it a day.

[mlamber5]

Based on the science I have looked over, I am more interested to see what a combination of a strong DP2 receptor blocker, upregulation of PGE2 and PGF2 alpha in combination will do over time. We do not yet know the extent of the ability of prostaglandins to reverse the balding process. It could be a total reversal is possible, perhaps not. If the stem cells are intact you just have to turn them on.

This is also what has me so interested. I think it is much more likely that we will first bring our own hair making "factories" back to life than we will be likely to make new ones all outside of our bald scalp and put them back in. There are a lot of interesting correlations with the prostaglandin deregulation theory. PGDS is androgen responsive. The coded protein only spikes during the regression stage a hallmark of AGA. I know it is only a mouse, but I think it is very important that one thing (over expression of COX-2 ----> way more PGDS and PGD2 as a result) exactly copied the AGA phenocopy of BOTH the enlarged sebaceous glands with miniaturized follicles. You don't see the bad androgen receptor gene and AGA line up 100% (although it is very high) which makes me think that something else is the main culprit which indirectly acts with androgen's. PGDS is also mildly expressed in the dermis where the dermal papillae are, so maybe PGDS coded PGD2 proteins through interaction with androgen's are what is causing the premature dermal senescence and cutting off the ability of the dermal sheath cells around the bottom of the follicle to reproduce healthy new dermal papilla. Prostaglandins play a major roll throughout almost all tissues of the body. This would explain why the phenotype of AGA is so broad. If it was all dermal papillae and its interaction with androgen's you would see not only a bad hair shaft but a bad outer and inner root sheath as they are also in contact with the dermal papilla and are instructed to grow by it. You see normal outer and inner root sheaths in AGA. Only the actual hair shaft and sebacious glands are way off.

I also think it speaks volumes the silence that is coming from Follica which I thought had pretty darn sound science, and Cotsarelis, the man behind the PGD2 science is involved with. And he has thrown his eggs into the PGD2 blocker publicly, maybe knowing more about what he thinks it will do than he is letting on. Notice how follica posted a the youtube video of his PGDS/PGD2 presentation last year on their webpage.

[mlamber5]

Yesteryears hype does not determine the success of science, lol.

This. For the first time in history the answer to the OP's original question actually has a snowballs chance in hell of being "yes." Between Replicel, kythera, sanford-burnham progress, histogen, etc many new fresh approaches are attacking the problem.

[burtandernie]

With all the new stuff on the way that rely on new approaches I would say nothing is impossible. I think realistically the odds are small, but any of the new stuff like seti or SM could turn out to be a major game changer. The answer is just no one has any clue until all this stuff releases info.
IMO any of the stem cell stuff like hair cloning or multiplication is a long long time away if it comes to that.

[Occulus]

http://www.follicabio.com/

Swanky website

That's interesting. The site looks like it was designed to address retail customers, not biotech investors. They must be getting close to announcing some sort of significant trial.

[hellouser]

Look at headlines and forum posts from 5 years ago and see what kinds of treatments people said would be out/game changers by now...then come here and see if the hype for these new products is comparable.

Yesteryears hype does not determine the success of science, lol.

[Hemo]

Look at headlines and forum posts from 5 years ago and see what kinds of treatments people said would be out/game changers by now...then come here and see if the hype for these new products is comparable.

[CurlyBird]

Based on the science I have looked over, I am more interested to see what a combination of a strong DP2 receptor blocker, upregulation of PGE2 and PGF2 alpha in combination will do over time. We do not yet know the extent of the ability of prostaglandins to reverse the balding process. It could be a total reversal is possible, perhaps not. If the stem cells are intact you just have to turn them on.

[Trenblastoise]

Thank you , Inbrugge but I have questioning mind that Replicel is REALLY feasible...

Replicel is economically backed by Shiseido - a huge and stable cosmetic Japanese company, which will also run studies/trials on the same thing. The only thing to doubt here is the time line I think.

[JayM]

And check out Rox Andersons moustache. Enough there to cover 2 bald heads aha

[JayM]

http://www.follicabio.com/

Swanky website

[GSD]

histogen is not dead, pls stop spreading such false information...

they have only funding problems because there are much better things in development.......

[Arieux]

I am in the same situation! Replicel + HT (piloscopy maybe) is my only hope.

And what about Follica? Everybody thought that it is dead, but a month ago their site was actualised and this treatment is in the recently presented Puretech's pipeline (http://puretechhealth.com/pipeline.php). Follica is actually under human trials, isn't it?

[runrunrun]

I'm in the same boat. I have diffuse loss on the crown and a little at the temples so I'm not exactly sure of my NW level, but I can't take fin and RU also gave me bad sides, though nothing sexual. The only thing I take now is minox and Niz. Seems like I'm really on the precipice of being a guy with thinning hair to a full blown baldie. Maybe a HT can bridge the gap? I don't know...I'm not very hopeful.

Was Histogen dead?