How far away are we from these technologies?

[asianguy]

1) stem cell and Hair follicle cloning
2) Technology to modify other people's hair follicles to use on your own head without using anti rejection medication
3) hair follicle regeneration in donor area
4) 90%+ Reactivation of dormant follicles from your younger years
5) extraction of donor follicles without visible scars to the naked eye

Which one of these would be likely and closest to reality?

[karxxx]

Melatonin Solution Found to Reverse Early Hair Loss in Men and Women

[BoSox]

2018 at the least.

[FearTheLoss]

1) stem cell and Hair follicle cloning
2) Technology to modify other people's hair follicles to use on your own head without using anti rejection medication
3) hair follicle regeneration in donor area
4) 90%+ Reactivation of dormant follicles from your younger years
5) extraction of donor follicles without visible scars to the naked eye

Which one of these would be likely and closest to reality?

#5, 2016.
#4, no one knows.
#3, could be 2016 (just watch and wait for pilofocus, it will be more refined as time goes by)
#2, no one knows, I don't think it's a major focus at all.
#1, no one knows.

[Trouse5858]

Imagine if you could transplant another guy's lush hair follicles of similar color and consistency onto your balding head without the dermis or epidermis rejecting it? That would be....AWESOME.

[hellouser]

Imagine if you could transplant another guy's lush hair follicles of similar color and consistency onto your balding head without the dermis or epidermis rejecting it? That would be....AWESOME.

Imagine if you could steal someone elses follicles and reverse social standing? You get a bit of pleasure in life at the expense of someone else? It's not like WE aren't on the receiving end right now... would be nice for US to be privileged for a bit.

[karxxx]

The invention will facilitate the transplant organs from Japanese
The invention will facilitate the transplant organs from Japanese
TUNCAY KAYAOĞLU - TOKYO
March 3, 2013, Sunday
Japanese experts to facilitate organ transplantation has signed an invention. Experts developed a new technique, the user can move the front of the body rejecting the transplanted organ. ALSO, organ transplants performed in the person's life should not remain in the use of medication.

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The news of the Asahi newspaper published in Japan Hokkaido Gore jointly developed by experts from the Juntendo University, Inc. routing techniques that are installed on the blood cells were recorded. Other plays a role in organ transplant rejection in blood cells was recorded. Studies on 10 patients, 4 patients in the frame, after organ transplantation are not using any medication that was lowering the rate of 6 six months on the drug significant other quantities.

Professor Satoru Todo from Hokkaido University, Juntendo University of Ile method developed jointly by Professor Ko Okumura, organ transplant recipients both before and getting the white blood cells of the donor. These two blood cells co-cultivated. 2 weeks after transplantation, these new blood cells are injected into the recipient's body.

Patients since November 2010. In view of Studies has been saved successfully.

(Xinhua)

http://www.zaman.com.tr/aile-saglik_japonlardan-organ-naklini-kolaylastiracak-bulus_2060414.html

http://www.alopezie.de/14-haarfollikelzuechtun

[nameless]

Imagine if you could transplant another guy's lush hair follicles of similar color and consistency onto your balding head without the dermis or epidermis rejecting it? That would be....AWESOME.

Yea and then who would give up their hair so that you could have a full head of hair? The donor would then be bald as you are bald - who is stupid enough to do that?
And don't say that you would buy the hair follicles of poor people in foreign countries because harvesting donor tissue in that manner would be considered highly unethical and it's doubtful that the medical community would be involved with that. It might even be illegal because you are talking about intentionally disfiguring another person so you could be better looking. I understand that you don't want be bald/disfigured but I do not think that the civilized medical community is going to be involved with you disfiguring another person (the donor) so that you can be cured of your disfigurement.

[Sogeking]

Has anyone seen this? http://hplusmagazine.com/2015/03/26/...tside-the-u-s/


Apparently in Brasil outside the jurisdiction of regulatory agencies they are offering anti-aging treatments. Untested ofcourse. Something is wrong here. They are ready to mess with telomeres but still no baldness cure. I get it now what hellouser was talking about.

Heh at this point I think I'm sooner gonna get anti-aging treatments than a baldness cure. Although in that case I have more time to wait for one.

[Kokles]

Has anyone seen this? http://hplusmagazine.com/2015/03/26/...tside-the-u-s/

Apparently in Brasil outside the jurisdiction of regulatory agencies they are offering anti-aging treatments. Untested ofcourse. Something is wrong here. They are ready to mess with telomeres but still no baldness cure.

For quite some time I have this hunch that lengthening telomeres in the cells responsible for hair could in fact restore some of the damage done by DHT. Balding might really just be a hyper-accelerated cell senescence triggered by DHT.

Mice (study link ) got their hair back in original youthful quality when the telomere lengthening enzyme telomerase was reactivated in their bodies (they were engineered to have little to no telomerase production in their cells). Not an evidence it would do anything for dht affected hair but ... what if?

[Trouse5858]

For quite some time I have this hunch that lengthening telomeres in the cells responsible for hair could in fact restore some of the damage done by DHT. Balding might really just be a hyper-accelerated cell senescence triggered by DHT.

Mice (study link ) got their hair back in original youthful quality when the telomere lengthening enzyme telomerase was reactivated in their bodies (they were engineered to have little to no telomerase production in their cells). Not an evidence it would do anything for dht affected hair but ... what if?

"If" that's the case then it will probably take around 2 or 3 years for somebody to come to that conclusion and actually pursue to to any meaningful degree. Add in another 2-3 years for hiring a team with scientific/ medical backgrounds, raising enough funds to carry out trials, R&D, refining the technique or medicine, getting FDA approval on a drug (3-5 years) and bringing it to market ( 2 years). Soo all told, that could be a real treatment in only 10-12 short years.

Not trying to be a dick. My point is simply that all these new "discoveries" about hair loss is a pretty discouraging sign. You would hope that by 2015, scientists have figured out just about everything there is to know about hair loss. How can you possibly supply a cure for something that is still widely misunderstood and unknown? Everyone on this thread is balding to some degree. It can be quite rapid for many people. For any drugs to help us in the short to intermediate term, the ball already needs to be rolling, significantly I would assume - to be able to do anything in a reasonable timeframe.

[hellouser]

For quite some time I have this hunch that lengthening telomeres in the cells responsible for hair could in fact restore some of the damage done by DHT. Balding might really just be a hyper-accelerated cell senescence triggered by DHT.

Mice (study link ) got their hair back in original youthful quality when the telomere lengthening enzyme telomerase was reactivated in their bodies (they were engineered to have little to no telomerase production in their cells). Not an evidence it would do anything for dht affected hair but ... what if?

Only way to tell is.... you guessed it, test on more mice.

[Swooping]

For quite some time I have this hunch that lengthening telomeres in the cells responsible for hair could in fact restore some of the damage done by DHT. Balding might really just be a hyper-accelerated cell senescence triggered by DHT.

Mice (study link ) got their hair back in original youthful quality when the telomere lengthening enzyme telomerase was reactivated in their bodies (they were engineered to have little to no telomerase production in their cells). Not an evidence it would do anything for dht affected hair but ... what if?

If you have hypothesized this from your own idea(s), then that is pretty damn impressive by you. The consensus seems to be heading into a altered cell cycle fate indeed by many researchers lately. Although it's not because of telomere shortening but rather an altered cell cycle fate because of oxidative stress & dna damage or a combination of both. In that sense one could argue it to be viewed as "accelerated aging" of the cells indeed. The situation is not pretty to say the least, and it's exactly why reversal of androgenetic alopecia is almost impossible to achieve. All the pipeline drugs are not going to pull it off, that's almost pretty much a fact. It would be no surprise to me that a better therapy or drug won't come from within the hairloss research field. Check for instance this link; http://www.sens.org/research/introdu...esistant-cells.

Nonetheless such a thing or a cell based cure will take many, many years. I would wish the pathology of Androgenetic Alopecia to be so superficial and easy to treat like Alopecia Areata but it's not unfortunately. It's a huge challenge.

[FearTheLoss]

If you have hypothesized this from your own idea(s), then that is pretty damn impressive by you. The consensus seems to be heading into a altered cell cycle fate indeed by many researchers lately. Although it's not because of telomere shortening but rather an altered cell cycle fate because of oxidative stress & dna damage or a combination of both. In that sense one could argue it to be viewed as "accelerated aging" of the cells indeed. The situation is not pretty to say the least, and it's exactly why reversal of androgenetic alopecia is almost impossible to achieve. All the pipeline drugs are not going to pull it off, that's almost pretty much a fact. It would be no surprise to me that a better therapy or drug won't come from within the hairloss research field. Check for instance this link; http://www.sens.org/research/introdu...esistant-cells.

Nonetheless such a thing or a cell based cure will take many, many years. I would wish the pathology of Androgenetic Alopecia to be so superficial and easy to treat like Alopecia Areata but it's not unfortunately. It's a huge challenge.

I agree. I think we may see drugs come out soon that do a better job of stopping the progression of AGA than propecia, or at least without the severe side effects. However, it's doubtful that AGA will be "reversed" using a drug anytime soon. It's just too complex to be attacked from one angle it seems.

I would bet we see major advancements in cell therapy that will be beneficial in the next 10 years. However, I personally believe the first "cure" for AGA, for most sufferers, will be in the form of perfecting donor regeneration.

[Kokles]

Although it's not because of telomere shortening but rather an altered cell cycle fate because of oxidative stress & dna damage or a combination of both. In that sense one could argue it to be viewed as "accelerated aging" of the cells indeed. The situation is not pretty to say the least, and it's exactly why reversal of androgenetic alopecia is almost impossible to achieve.

Why I think that at least some of the damage could be reversed is because cells that appear younger (it was proven that when skin cells appeared "genetically" young again when treated with telomerase in vitro) are more resilient and they are better at activating their various genes when needed (telomere fold back model could explain this). This could theoretically mean, that they could just simply overcome the damage done by DHT and function almost normally or just a bit better.

BTW there is a product on the market with a one of a kind small molecule that in human skin cells caused in vitro heightened telomerase expression - up to ~15% of the telomerase gene expression found in a type of "immortal" cancer cells. It got to the market because it could be described as a cosmetics product (similar to follicept approach).. funny