Where are the phase IIb results for Bimatoprost?

[nave13579]

I think that makes sense. You don't want to blow all your good news at once, either. The merger has been great for their stock/company value. Having this sort of news in your back pocket would also be very useful when the buzz starts to die down.

Sorry what was the merger? Allergan with Kythera?

[FearTheLoss]

after reading a latanoprost study where 50% of patients had a density increase of 22%+ on average at 20 weeks, I have high hopes for bim. they used a .1% concentration in the study, so I think the key is using a higher concentration.

[It's2014ComeOnAlready]

Sorry what was the merger? Allergan with Kythera?

No they merged with Actavis, and the stock is through the roof. Allergan and Kythera keep getting mentioned together because both their potential products work on prostaglandins.

[It's2014ComeOnAlready]

after reading a latanoprost study where 50% of patients had a density increase of 22%+ on average at 20 weeks, I have high hopes for bim. they used a .1% concentration in the study, so I think the key is using a higher concentration.

.1 x 100 = 10, so if it's 10% concentration they're using, then expect significantly more density and percentage of patients for which it works.

It may be wishful thinking, but by not releasing info about phase 2b has a lot to do with wanting to control how they release good news. Next year no one will care about the merger, they will want to see what Allergan produces from it's R&D.

[BiqqieSmalls]

I think that makes sense. You don't want to blow all your good news at once, either. The merger has been great for their stock/company value. Having this sort of news in your back pocket would also be very useful when the buzz starts to die down.

Exactly. They worked with top tier consultants who know the market and obviously did their due diligence and thus decided to release results later.

[FearTheLoss]

Yeah but bimatoprost is extremely expensive to produce. I'm not sure they could bring a 10% bim treatment to market at a price that's affordable for anyone.

[It's2014ComeOnAlready]

Yeah but bimatoprost is extremely expensive to produce. I'm not sure they could bring a 10% bim treatment to market at a price that's affordable for anyone.

even when it's mass-produced all over the world?

[Dimoxynil]

Yeah but bimatoprost is extremely expensive to produce. I'm not sure they could bring a 10% bim treatment to market at a price that's affordable for anyone.

There are ways to get wholesale prices down

[It's2014ComeOnAlready]

Did some digging and came across the most recent patent for bimatoprost for hair loss. This patent was filed in Feb. of 2014, and Published in Oct. of 2014, after they had their phase 2A. Had some really interesting information that could help clear up some about their issues with concentration etc., if anything, it has me feeling a lot more optimistic.

great quote: "The preferred bimatoprost concentration range is about 2-4%, more preferably about 2.5-3.5%. These preferred bimatoprost ranges allow a surprisingly good balance to be achieved between the wanted pharmacologic effects of the composition and any unwanted side-effects. It had previously been thought that bimatoprost compositions for stimulating growth of hair should have a much lower bimatoprost concentration; this has now surprisingly been found not to be the case."

It also mentions the aim of the drug which is to darken and thicken existing hair, by extending the anagen phase, which is typically 3-5 years. This means by applying bimatoprost daily for a number of weeks, you can change the cycle of your thinning hair and keep it for much longer. There is a lot in there about making thinning hair into terminal hair, which should make people on here happy.

There is also mention of how it would be applied, and there is mention in the patent for gels, foam, cream, lotion, shampoo, and spray. So who knows how it will be delivered to the scalp, but we do know they have a wide range to choose from, and will pick the best option.

Here it is, if anyone wants to have a look:

https://www.google.com/patents/WO2014158373A1?cl=en&dq=bimatoprost+hair+loss&hl=en&sa=X&ei=NYMXVYriH6_nsATRnoH4Cw&ved=0CCQQ6AEwAQ

[Hairismylife]

How about the slick bald scalp?

[Keki]

**** this phase i want bim tomorrow morning, but this concentration means it will be expensive af

[FearTheLoss]

Yes, indeed this news is fantastic, as this hints at their results being positive. However, it will be unaffordable on the black market at this concentration. We will have to wait for it to be released.

Good find its2014

[It's2014ComeOnAlready]

How about the slick bald scalp?

Thickens existing hair. If there is no follicle present, or if it's so small or vellus, probably won't create cosmetically significant hair.

[FearTheLoss]

Thickens existing hair. If there is no follicle present, or if it's so small or vellus, probably won't create cosmetically significant hair.

True, however, I'd guess just like with minoxidil there will be some patients that see ridiculous results every now and then. Man I'm excited to see their results posted. I hope this patent is as telling to bims future as it seems.

[FearTheLoss]

" A 37 year old Hispanic male suffering from male pattern baldness due to androgenetic alopecia applies the 0.2% w/w bimatoprost composition of Table 3 twice daily in areas where hair is noticeably thinning. After 63 days of application, increased growth of hair will be noticed as will be new hair growth as measured by high magnification at the slit lamp biomicroscope and by computer assisted image analysis. After satisfactory levels of hair growth are observed, the patient applies the 0.2% w/w bimatoprost composition only twice a week."