follicept - what's this?

[MoolahLea]

Reply from LifeTech

Hey Devon & team,

Tried reaching out to this local company who then forwarded it to their other offices. This was their reply. Still trying my best to look for other vendors though... Don't lose faith!

Dear Murrali,

Thank you for contacting Life Technologies Technical Support, now part of Thermo Fisher Scientific.

Unfortunately, the IGF-1 we have is for research use only. Please follow the link for the product page:

https://www.lifetechnologies.com/order/catalog/product/PHG0078?ICID=search-product

Please let us know if we could help with any other question.

Best regards,


Alok Gupta Ph.D.
Technical Application Scientist
Life Sciences Solutions

Thermo Fisher Scientific

https://www.lifetechnologies.com

This communication is intended solely for the individual/entity to whom it is addressed. It may contain confidential or legally privileged information. Any unauthorised disclosure or copying is prohibited and may be unlawful. If you have received this communication in error, please notify the sender immediately and delete it from your system.


[THREAD ID:2-1FHECVS]



-----Original Message-----

From: Orders.SG@lifetech.com
To: "Technical Support, Singapore" <TechSupportSingapore@lifetech.com>
Subject: FW: IGF-1

Hi Team

Can you assist customer with:
FDA cGMP compliant clinical grade recombinant IGF-1 from microbial fermentation for research use?

Thank you.

Do let me know should you need further assistance.

Getting quotations was never this Easy and Fast !
Get an online quotation 24/7 at www.lifetechnologies.com<http://www.lifetechnologies.com/>


Cindy Wang
Lead Customer Care Representative, Singapore
Life Sciences Solutions

Thermo Fisher Scientific
Life Technologies Holdings Pte Ltd
Blk 33 #07-06 |Marsiling Industrial Estate Road 3 |Singapore 739256
Direct: +(65) 6861 8638 |Fax : +(65) 6861 9391
orders.sg@lifetech.com<mailto<img sr...g@lifetech.com> |www.lifetechnologies.com<http://www.lifetechnologies.com>

Please know that while Life Technologies has been acquired by Thermo Fisher Scientific, our ordering processes and representatives remain the same. You can continue to process orders, and pay invoices to the required Life Technologies legal entity as done previously. We look forward to continuing to provide you with outstanding service and support.

This email and its attachments are confidential. If you received this email in error, please notify the sender and delete.

From: M.O.B Ink-Werkz [mailto:d_e*****c_s@hotmail.com]
Sent: Thursday, April 02, 2015 7:00 AM
To: SG, Orders
Subject: IGF-1

Hello there,

a University-affiliated company, is seeking seeking FDA cGMP compliant clinical grade recombinant IGF-1 from microbial fermentation for research use.

Do you manufacture this, and/or do you have a process developed to do so?

If so, do you have a minimum order/batch size, what are the approximate startup costs, and what is your maximum capacity?

Thank you!

With Regards,

Murrali
© 2015 Microsoft Terms Privacy & cookies Developers English (United States)

[NeedHairASAP]

In the mean time you could try research grade on gerbils or hampsters, who are much similar to humans (for hairloss research purposes) than are mice.


Aminoglycoside ototoxicity and hair cell ablation in the adult gerbil: A simple model to study hair cell loss andregeneration.
Hear Res. 2015 Mar 14. pii: S0378-5955(15)00059-3. doi: 10.1016/j.heares.2015.03.002. [Epub ahead of print]
Aminoglycoside ototoxicity and hair cell ablation in the adult gerbil: A simple model to study hair cell loss andregeneration.
Abbas L1, Rivolta MN2.
Author information
Abstract
The Mongolian gerbil, Meriones unguiculatus, has been widely employed as a model for studies of the inner ear. In spite of its established use for auditory research, no robust protocols to induce ototoxic hair cell damage have been developed for this species. In this paper, we demonstrate the development of an aminoglycoside-induced model of hair cell loss, using kanamycin potentiated by the loop diuretic furosemide. Interestingly, we show that the gerbil is relatively insensitive to gentamicin compared to kanamycin, and that bumetanide is ineffective in potentiating the ototoxicity of the drug. We also examine the pathology of the spiral ganglion after chronic, long-term hair cell damage. Remarkably, there is little or no neuronal loss following the ototoxic insult, even at 8 months post-damage. This is similar to the situation often seen in the human, where functioning neurons can persist even decades after hair cell loss, contrasting with the rapid, secondary degeneration found in rats, mice and other small mammals. We propose that the combination of these factors makes the gerbil a good model for ototoxic damage by induced hair cell loss.
Copyright © 2015. Published by Elsevier B.V.

source:

http://learnmorehere666666666.blogspot.com/2015/04/aminoglycoside-ototoxicity-and-hair.html

[Keki]

Guys it's a waste of time, i've seen every trial published in internet, when used in human is always increlex, nothing else, i challange you finding a trial/study when the igf-1 used is not increlex. If it's not increlex is just injected on rats,and we can find igf-1 for rats everywhere.
I 've found the manufacture and the equivalent of increlex, there are other igf-1 but are like mexican and i don't trust it very much, the only pure igf-1 used on human approved by fda and in europe is increlex

the manufacture is hospira and the main pharma is ipsen, that's what we need

[KJ1982]

Whilst this is quite an old video now, I just found this on YouTube; an interview with Dr. Hsu about the next generation patch for insulin delivery.

Granted, it's not directly concerning using IGF-1 with the patch but I found it quite interesting so thought it worth a share.

https://www.youtube.com/watch?v=uVWlSAKsmVQ

[nameless]

lol... times have changed. bio-med startup costs are now low enough that you'll see a lot more small-team companies like this (especially working to commercialize the IP of university research)

Jar Jar binx (aka nameless) has always been kind of slow but come on

But below is a post by you at a different site where you state that other companies/researchers are not doing the same thing as Follicept in terms of Follicept's open style of conducting business, which would include things like asking regular-Joes at hair websites to help set-up clinical trials. Here check out your own words:

"This is why I'll be happy to see more companies like the follicept team who are 1. open and 2. working on a days timetable, not a decades timetable"

[burtandernie]

Why not use the topical delivery system to deliver tiny amounts of RU effectively since RU is one of the most potent AAs ever invented?

[serenemoon]

Why not use the topical delivery system to deliver tiny amounts of RU effectively since RU is one of the most potent AAs ever invented?

From what I have gathered, it is because IGF-1 is considered "natural" and therefore Follicept will be considered a natural OTC product by the FDA. Also a very low dose will be used which will help. Which means no clinical trials will be needed and they can go straight to the market. (Even though the company is going to do some short trials anyway to show the effectiveness.) However, if they tried use RU, it will fall under the "drug" arena and that means probably 5 years of clinical trials before even thinking about getting to the market. I think it is great that they are trying the easiest route that will probably be quite effective instead of waiting for so long. After Follicept, they can experiment with other chemicals/drugs.

[joachim]

as follicept's IP is protected anyway, I think Devon should find a way to allow others to use buy and use their vehicle. e.g. if he could allow Kane or other chemists guys to use the vehicle, this would be a true gamechanger. you could use everything with it. RU, minox, lots of other growth factors etc. in very low doses. Devon should only sell them the licences or the vehicle itself. as long as he doesn't know how the vehicle is used, he doesnt have to care about the legal side of it. as far as i know, Kane also sells his stuff for "research purposes" only, no? the fact that buyers use if to treat their own hairloss is another story.

[noisette]

For anybody who wants to see Dr. Stephen Hsu (until the beginning of the trial) : wait and see, and listen ! lol

https://youtu.be/ehAe-yD8m3Y?t=22s

[benutzer81]

For anybody who wants to see Dr. Stephen Hsu (until the beginning of the trial) : wait and see, and listen ! lol

https://youtu.be/ehAe-yD8m3Y?t=22s

From what i see, there are good conditions to do in-house trials

[Illusion]

Sadly i'm going through a shedding (dunno if it's the season) phase and i lost another 10% of my hairs, i wish i could know if this works so i can avoid taking pills, but i don't think we will see a trial before another month, well i will wait the supplier update next week then i will pull the trigger and start with fina if they are still doing "paper stuff" sigh, it's the unknown schedule that it's hurting us, and i know devon is doing his best

"Pull the trigger" now. Don't hesitate. Get on fin and enjoy your hair.

Or you could wait and make your happiness depend on whenever follicept, a treatment of which you don't even know whether it works or not and also don't know whether it will be good enough to be a stand alone treatment, is coming to the market.


So you have 2 choices, one will make you feel good and will put your mind at ease and the other one makes you feel hopeless and anxious as ****. Easy choice if you put it like this, no?

[joel203]

"Pull the trigger" now. Don't hesitate. Get on fin and enjoy your hair.

Or you could wait and make your happiness depend on whenever follicept, a treatment of which you don't even know whether it works or not and also don't know whether it will be good enough to be a stand alone treatment, is coming to the market.




So you have 2 choices, one will make you feel good and will put your mind at ease and the other one makes you feel hopeless and anxious as ****. Easy choice if you put it like this, no?

ur typing as if fin can save and keep hair

[noisette]

Androgen induction of steroid 5 alpha-reductase may be mediated via IGF1

I don't know if this abstract was already published here:

" These studies indicate that IGF-I may be an important regulator of skin 5 alpha R activity and, thus, may influence DHT formation "

Abstract

The action of added insulin-like growth factor-I (IGF-I) and dihydrotestosterone (DHT) on steroid 5 alpha-reductase (5 alpha R) activity was studied using primary cultures of rat or human scrotal skin fibroblasts. Agents were added to cultured cells (2 x 10(5) cells) for 2 days, and enzyme activity was measured by the percent conversion of [3H] testosterone to DHT over a 4-h period in the absence of fetal calf serum or other growth factors. DHT, but not testosterone, at 10(-7) M significantly increased 5 alpha R activity (rat, 1.5 +/- 0.3% to 3.0 +/- 0.4%; human, 7.6 +/- 1.7% to 11.4 +/- 2.9%; P < 0.01). IGF-I (10(-9)-6.4 x 10(-9) M), but not IGF-II (10(-9)-10(-8) M) or insulin (10(-9)-10(-7) M), increased enzyme activity in a dose-related fashion [i.e. 1.5 +/- 0.5 to 10 +/- 2 in rat and 6.0 +/- 1.1 to 9.8 +/- 1.6% (P < 0.01) in human cells]. No change in cell numbers was observed in any experiment. Since the effect of IGF-I was about 100 times that of androgen, we studied the possibility that androgen induction of the enzyme activity could be via IGF-I production. Addition of a monoclonal antibody against IGF-I significantly reduced the effect of DHT, and simultaneous addition of a specific IGF-I receptor antibody blocked the expected induction of 5 alpha R activity (control, 4.9 +/- 0.5; DHT, 8.0 +/- 1.9; DHT plus IGF-I receptor antibody, 3.7 +/- 0.4%). No effect on 3 alpha-reduction of [3H]DHT to 3 alpha-androstanediol was detected in separate experiments. These studies indicate that IGF-I may be an important regulator of skin 5 alpha R activity and, thus, may influence DHT formation. The previously known androgen induction of this peripheral steroidogenic enzyme may be via paracrine/autocrine production of an IGF-I-type growth factor.

[Hemo]

LOL this is why you don't announce a product prematurely...who knows if they'll even be able to get IGF-1 within 6 months.

[doinmyheadin]

ur typing as if fin can save and keep hair

There is a 10 year study on Fin and its effectiveness.