OC and setipip news

[It's2014ComeOnAlready]

Also, if you look at the amount of money that has been moved based on knowledge about prostaglandins, that should tell you something. Just because all the information hasn't yet been made public doesn't mean it isn't so.

[Swooping]

Not wishful thinking. Here's the article: http://www.bloomberg.com/news/articl...ill-be-delayed

Now, what was the effect of this trial? Shares fell. After the most recent trial - 66 billion dollar acquisition, stock prices soar, kythera announces they will begin trials with setipiprant. You seem to behind in the news, they ran a 2a trial which didn't show much, then they ran 2b trial at 10X the concentration. That trial ended in November, when Allergan was acquired by Actavis.

Cause and effect.

By the way, the results of the phase 2a were known a few months after the trial was completed. You're just biased about all of this. I don't need to prove anything to you, because I've done my homework. I suggest you do yours.

Sure thanks you did update me on some new findings that I didn't know.I didn't know the actual amount was 10x as much. However that says nothing, literally nothing. 1mg of finasteride doesn't differ much more than 10mg, as does 5% minoxidil to 15% minoxidil.

Also Allergan was insanely rapid with providing results and shouting their positive results with their DARPin trial for macular degeneration. They immediately released a statement that they will rapidly proceed to a phase 3 trial in Q2 of 2015 for this compound; http://www.pmlive.com/pharma_news/al...xt_year_581662.

Why not with bimatoprost for AGA? Why are they so horribly quiet at the moment?

[Swooping]

Allergan took less than 3 months after completion of phase 2 of DARPin to immediately give out a confirmation & presentation of their positive results with the compound. Within the same time they confirmed to rapidly proceed to a phase 3 trial in Q2 this year; http://www.allergan.com/assets/pdf/r...jun30_2014.pdf

However with bimatoprost for AGA they won't release the results for a year? Still no confirmation of a phase 3 trial? That's odd! Guess they have much to think about ?

[It's2014ComeOnAlready]

Allergan took less than 3 months after completion of phase 2 of DARPin to immediately give out a confirmation & presentation of their positive results with the compound. Within the same time they confirmed to rapidly proceed to a phase 3 trial in Q2 this year; http://www.allergan.com/assets/pdf/r...jun30_2014.pdf

However with bimatoprost for AGA they won't release the results for a year? Still no confirmation of a phase 3 trial? That's odd! Guess they have much to think about ?

You missed the point. When they launched this program, what they had in mind was a treatment superior to minoxidil that also has the added benefit of working anywhere on the scalp. They had no plans of releasing this drug if it was marginally better, and those were the results they got from phase 2a. In 2b, they tried 10x that concentration. If it didn't work, there wouldn't be anything stopping them from saying it didn't work, and the program has been shut down. However, they believed enough in this drug and that it needed to be upped in concentration to show better efficacy. If it did, that means they are a trial away from releasing bimatoprost as a treatment.

If a drug has succeeded in making a significant difference in your hair loss, there's just no chance in hell that the company who's on the verge of making billions (per their estimate) will let everyone know they have something as soon as they know. They keep things moving to get it out and make money as soon as possible.

I doubt the success is a mystery to shareholders, or Kythera, whose Chief Medical Officer spent years previously at Allergan (no coincidence). Kythera has been working with Cotsarelis and felt confident enough that they would focus on the development of setipiprant for hair loss, exclusively. They have no other drugs in the pipeline. No company with this amount of value, or expertise will ever gamble their future on something that wasn't as close to a sure deal as possible. They will not pin their hopes on a drug that won't work. There's too much at stake for them.

[sdsurfin]

Swooping is too broadly negative without having real data or citing good evidence of his own. Garza never said anything about not having faith in this approach. I emailed with him a while ago and he said that they knew the PGD2 thing has promise, but it was a matter of finding the right drug. Prostaglandins are being backed by big people, people who stand to lose money. Cotsarellis does not want to waste anyones time either. there's definitely potential, and I think it will turn out well, especially for maintenance and people with early loss. And Im with 2014 on the BIM call, I think they will try to release it and are holding out because of that. its a guess, but a good one. They might also have had decent results and might be deciding whether or not to go ahead with it. Either way minoxidil is looking like it might become a thing of the past. Between BIM and SM and follicept and others, its only a matter of time. My guess is the PDG2 blockers and BIM will be released as a one two punch. Of course everything could fail, but at this point I think that's less likely than it has been in the past. Most of the therapies that have failed so far have either been cell based, with not enough science done on them at that point, or anti androgens that carried pretty heavy side effect risks. But i honestly can't name more than one or two drugs specifically made for hair loss that have failed. most of the ones people cite are like aderans or intercytex, and those technologies were not quite there yet. we already have anecdotal evidence that PGD2 blockers and BIM work to a large degree.

Kythera would not waste time trialling setipiprant if they didn't think it was going to work. their trials might be cheap compared to most but they will still cost. It's a win win for action, and thats why they are using this PGD2 blocker and not another one, among other reasons. if these guys and Upenn think it has a good chance then there's no reason to say "oh this has no chance" I'll hold out hope for the guys who are professionals to be right. I think hands down it will help to some extent, so let's hope they release it.


PS I've been using cetirizine and it has helped the itch. also no side effects anymore. except maybe possibly a bit of drowsiness, but i use it at night. not sure if its doing much for my hair, but if the side effect profile is similar for setipi then it'll probably be very tolerable. i get sides from everything. had to quit RU two weeks in cause i felt destroyed by it, sore balls and just shitty in general, feeling like i lost my life force.

[PinotQ]

You are entitled to your own opinion, but your arguments are mostly negative speculation based on old information.

Prostaglandin technology is a new school of thought when it comes to battling male pattern baldness. A PGD2 inhibitor (setipiprant) and a prostaglandin analogue (bimatoprost) have always been linked. One claims it can halt hair loss, the other claims it can make existing hair thicker, and with more pigmentation. When the phase 2b study for bimatoprost in AGA was completed, Allergan was acquired by Actavis for a record-breaking sum in the pharma industry, with the stock going through the roof (and continues to climb). If the drug had failed in the trial, then it would've been stopped, and we'd hear nothing more about prostaglandins and hair.

Quite the opposite has happened. Not only did we see the acquisition, the stock grew exponentially, but we also saw that Kythera wants to trial a drug that blocks the GPR44 receptor. This is now the ONLY drug in their trials, and after two years of working with Cotsarelis at his lab, they are trialling it. They wouldn't put their eggs in one basket, or take the risk of trialling a drug for hair loss (after there have been so many misses by others) unless they had some assurance that this works.

It works, the science is real, and the pharma industry's actions prove that they firmly believe this will work. Kythera is not the sort of company who can afford a failure or a gamble on a drug their not certain will stop hair loss. Like I said before, it's the ONLY drug in their pipeline, it is their future. They have decided on it. Sorry you don't agree with PGD2 causing hair loss or whatever, but Cotsarelis is the head of Dermatology at UPenn and has done years of research on this. A company has decided to take up his work, and spend MILLIONS of dollars to try and produce it. They would need to be damn sure it works, if they were going to take that risk.

You just need to look for the right signals or bits of information. I think you are missing them.

I'm not saying anything negative about BIM as I think it has a good shot of being another step forward. But I follow business and stocks very closely and had happened to own Allergan at the time of the takeover....and the takeover price has absolutely nothing to do with BIM. This was about a company with a lot of value that Valeant was going to buy and gut the research budget as is their business model. Valeant is in the business of taking over pharmaceuticals, getting rid of research and letting that 20% or so expense fall to the bottom line as profit and as a way to pay for the takeover. We are lucky that Activis bought Allergan instead so that BIM trials will continue.

[KO1]

Has anyone looked at these results? Oddly, Minot sponsored by Allergan

https://clinicaltrials.gov/ct2/show/results/NCT02170662?term=Bimatoprost&rank=15&sect=X70156#outcome1

[Swooping]

I'm not saying anything negative about BIM as I think it has a good shot of being another step forward. But I follow business and stocks very closely and had happened to own Allergan at the time of the takeover....and the takeover price has absolutely nothing to do with BIM. This was about a company with a lot of value that Valeant was going to buy and gut the research budget as is their business model. Valeant is in the business of taking over pharmaceuticals, getting rid of research and letting that 20% or so expense fall to the bottom line as profit and as a way to pay for the takeover. We are lucky that Activis bought Allergan instead so that BIM trials will continue.

Well there you go. Guess you only depend on Cotsarelis now It's2014ComeOnAlready. Because he is the "head of dermatology". You know what's funny? He said 3 times in the past that a cure would arrive within 5 years. Always the biggest mouth of all researchers. Yet he never showed any results, how ironic is that! Time for retirement after his seti fail. Results are that matter again, and bimatoprost is still outperformed by minoxidil until they show otherwise. Upjohn must really be laughing their asses off. For over 35 years nobody can come close. Anyway we will know everything soon when results will be published.

[Jasari]

Just got an email from Kane selling Setip for $130 for 10G

[FeelsBad]

When will he be able to sell it?

[Jasari]

Dear friend,

This is Kane Team from Kouting China.We can`t sell OC,TM,BIO,DKK etc on shop because of paypal issue.
We`re glad to offer better service with product cheaper and cheaper. We`re glad to bring more value to our customers.
ASC-J9 917813-54-8 ≥99%
17 alpha-propionate 19608-29-8 ≥98%
Ramantroban 116649-85-5 ≥98%
OC000459 salt 851723-84-7 ≥98%
TM30089 844639-57-2 ≥99%
BIO 667463-62-9 ≥98%
Dkk-1 Inhibitor；WAY-262611, HCl 1123231-07-1 ≥98%
Setipiprant(ACT-129968) 866460-33-5 ≥98%
Above products` prices are adjusted 40-60% off. OC is $150/g for GB.,same as TM,DKK,BIO,CB.
Setipitrant is only $130/10g for GB.
You can check our website to check more price details.

From what I understand Setip needs to be around 2g per day? So $130/10g is way too expensive.

[Justinian]

From what I understand Setip needs to be around 2g per day? So $130/10g is way too expensive.

That's for oral right?

Are these group buys raw powder?

[nave13579]

My understanding is you want 100mg - 500mg a day if you go the oral method

[Atum]

From what I understand Setip needs to be around 2g per day? So $130/10g is way too expensive.

How's that?

[Illusion]

That's for oral right?

Yeah 2g/day would be oral but I don't know if a topical is possible. Well, ofc you can try but if I recall correctly I believe there were some vehicle /dosage problems? Might just be the standard experiment-treatment problem stuff though (aka "this is new how the **** are we going to do this"), not sure.