OC and setipip news

[It's2014ComeOnAlready]

So what is the current state of setipip?
In the thread "Summer cutting edge treatments update: 2015" it says there will be a POC study 2016.
On the other hand, the active component seems to be available already on the market so that people could use it if they knew dosage and vehicle. Or find it out through experimentation. Oral taking also does not need a vehicle. My guess is that it is still pretty expensive right now. Are there already people using it? When might we be able to use it?

Well, the case of Setipiprant is very interesting. It has 8 clinical trials completed, including a phase 3 and safety data with thousands of patients. Under the current FDA rules, they'd have to complete a phase 2 poc and a phase 3. However, there is a bill that just passed Congress that has almost universal support, called the "21st Century Cures Act." I'd say there is a 95% chance it gets signed into law. The plan has also always been to sign it into law before the year is out, because 2016 is an election year.

Under the new law, I strongly believe a drug like this will get consideration for it's vast safety data and the number of trials it has already completed. It may just have to show efficacy.

[mlamber5]

Honestly, I think the drugs in trials that will benefit the most are likely bimatoprost and setipiprant.

Bimatoprost, because it's already on the market, has undergone as much as a phase 2b trial. There's also a provision for drugs that are repurposed. In this case, it would be eyelashes to hair.

Setipiprant, because it's undergone 8 clinical trials, including a phase 3. It has safety data on thousands of patients. There is much that is already known about this drug through data. The only thing that is missing is efficacy for hair loss. If the plan for the 21st Century Cures Act is to streamline the process, then it would be doing just that for a drug that has safely passed 8 clinical trials, and had a phase 3. Also "cures" hair loss for future generations.

I'm very optimistic because of how a lot of things are aligning. It might seem like this will never end, but for how badly things have gone, there is finally a GIANT and very well-funded company with well-researched drugs that will be able to solve hair loss for the masses. Simultaneously, there is a bill which plans to streamline, speed up, and modernize clinical trials. It just passed the house with 82% of the vote, and will likely be signed into law before the year is out.

I am speculating to a degree. If all that time, research, and drug development has amounted to two complementing, effective, drugs already in phase 2, and there is a law that will speed everything up...then this will be resolved rather soon.

Well said. Agree on all points. Optimism has never been higher in my mind. I think by 2020 we'll have multiple new effective avenues to attack AGA, vastly superior to anti DHT and minoxidil.

[burtandernie]

Its 2015 right now. I hope its not 2020 before anything new shows up that is a long time. I dont live forever unfortunately so time does matter.

[It's2014ComeOnAlready]

Its 2015 right now. I hope its not 2020 before anything new shows up that is a long time. I dont live forever unfortunately so time does matter.

I agree, and I think we will have at least 1 new, very effective option between now and then. If nothing shows up in 2 years, scrounge up as much cash as you can, fly to Japan, and get replicel done. If it takes 2 round trips and $20,000, then do it. That's exactly what I'm going to do.

If it takes getting a loan from a bank, do it. There is no sense languishing over this for the next 5 years, or being on fin for that much longer. I've been on fin for the past 2 years, and while I'm grateful that I'm not on the norwood scale, I've hated every minute of being on this drug.

[Dench57]

You're not on the norwood scale...? Why are you on Fin?

[It's2014ComeOnAlready]

You're not on the norwood scale...? Why are you on Fin?

Caught it early. Would otherwise be a norwood 5-6 in a few years if I hadn't.

[JayM]

Caught it early. Would otherwise be a norwood 5-6 in a few years if I hadn't.

I hope you were touching wood.

[It's2014ComeOnAlready]

I hope you were touching wood.

What?

[mlamber5]

Its 2015 right now. I hope its not 2020 before anything new shows up that is a long time. I dont live forever unfortunately so time does matter.

Guess i should've stated my last post differently. I meant that I think there will be something different and more effective than fin and minoxidil before 2020, and by 2020 we'll have multiple different things more effective. As someone who quit fin about 4-5 years ago, I am counting on this lol. I do not regret stopping fin though. I didn't have major sides on it, but i had some minor ones and in general just feel better off of it. My hair has suffered though. As my NW has progressed from NW 1.5 to NW 4 in about 4/5 years, I can tell you that time also matters to me. I'm still in my mid 20's and would like to have something by/before my 30's.

[hellouser]

Guess i should've stated my last post differently. I meant that I think there will be something different and more effective than fin and minoxidil before 2020, and by 2020 we'll have multiple different things more effective. As someone who quit fin about 4-5 years ago, I am counting on this lol. I do not regret stopping fin though. I didn't have major sides on it, but i had some minor ones and in general just feel better off of it. My hair has suffered though. As my NW has progressed from NW 1.5 to NW 4 in about 4/5 years, I can tell you that time also matters to me. I'm still in my mid 20's and would like to have something by/before my 30's.

God damn, that is rough.

[Farkhairloss]

Has anyone recieved there seti from the original group buy? I am very keen if there is another buy??

[BottleCap]

The first group buy has been shipped.

There is now a second PHG group buy for seti. Anyone who missed out on the first one PM me and I shall redirect you to the organisers.

$340 for 25g we just need enough people to commit.

[JayM]

What?

Never heard of that saying? When you say something but it could quickly change you touch wood. So you said you could have been nw5 in a few years if it wasn't for fin. (touch wood). Because that could still happen.

[It's2014ComeOnAlready]

Never heard of that saying? When you say something but it could quickly change you touch wood. So you said you could have been nw5 in a few years if it wasn't for fin. (touch wood). Because that could still happen.

lol of course I know the expression. Nah, I doubt it will. I've been a great responder to fin. Technically, I haven't "lost" any hair over the past two years I've been on it, it's just slightly thinner in certain areas. That's why I want bim so bad. Instead of taking fin every day, I want to microdose a few times a week, apply bim on the in-between days. Not because I want my hair to be "perfect" but to eliminate all side effects.

[mlamber5]

God damn, that is rough.

I know! Part of me wants to get back on fin, but I really do think we'll have something by 2020 if not before. That's why im holding out. I know that is logic many on here find insane but that's just me. From my own personal/family history of prostaglandin issues and early onset aggressive male pattern baldness, I am so hopeful that setipiprant/bimatoprost may just be what we've been waiting for forever.