OC and setipip news

[Hairismylife]

Swooping, so you don't think there is a vey good chance that setipip will work for aga?

Swoop is a naysayer to the whole pgd2 theory.
Anything falls within this scope won't work in his mind.

[FearTheLoss]

I doubt that. Cots has been working on it for awhile and trialled more than just seti in vitro. They tried numerous pgd2 inhibitors and decided seti in oral form was the best.

[FeelsBad]

Swooping, so you don't think there is a vey good chance that setipip will work for aga?

[Swooping]

I wouldn't be surprised if Kythera just picked it up for some spare change, literally nothing. Due to established safety they can rapidly initiate a human trial. Actelion wanted to throw the compound in the thrash can anyway so they get some spare money from it, always better than nothing. With the outlook of possibly getting more. So for Kythera it's a win, pick up a compound for almost nothing and Actelion wanted to get rid of it anyway and in return they get a bit out of it. A win-win situation.

I doubt they will be using way higher dosages. Oral dosages of 1 gram per day were given in trials of setipiprant. 1 gram is much and just shows that setipiprant isn't potent. There are several other CRTH2 antagonists in clinical trials who are way more potent. For example; OC459, ADC3680 and some others.

Cotsarelis and Kythera just both hope for validity for their hypothesis that's it. They have gotten a cheap opportunity now. We will also get to know soon if the ying yang theory (PGD2/PGE2) of AGA proves to be true.

[FearTheLoss]

Which begs the question, why specifically did cots choose seti? Will they be using it at a much higher dose?

I mean cots knows everything about this drug, they didn't chose it for nothing.

[Swooping]

I just found this article from 2012 that says clinical trials on setipiprant were canceled due to lack of efficacy. Can someone explain?

http://www.rttnews.com/1852195/actel...-rhinitis.aspx

It has failed 7 clinical trials due to displaying almost no efficiency. Basically the same effects were attained as placebo. Although this wasn't directed to androgenetic alopecia. Due to these results Actelion basically throwed setipiprant in the trash can and are working with a compound which is "100x" more potent than setipiprant itself. They probably think that a more potent compound will actually do something.

[FeelsBad]

I just found this article from 2012 that says clinical trials on setipiprant were canceled due to lack of efficacy. Can someone explain?

http://www.rttnews.com/1852195/actelion-to-end-setipiprant-clinical-development-in-asthma-allergic-rhinitis.aspx

[Coizi]

Well to be honest at the moment i got chronicel diseas (coughing and al that shit over and over again and my doc prescribed me AERIUS funny iTS from merc and co but i do notie less hair faling out maybe iTS just my mind but AERIUS is also à pdg2 Blokker on prescription lol

[Johnny2000]

can someone explaine to me, without being to technicel, what this product is and does? are we talking regrowth, if so, how much? is there a shedding face like minox?


i am from denmark, is it possible to get thhrough custom without any problems?

[Atum]

Is it possible for Europe aswell?

[unbalding]

I think that we're all getting splintered in our efforts. Instead of divvying up time between OC and seti, I say we all focus on ONE molecule, whether it be seti or OC we can decide, and put together a list of suppliers that can be our supply chain and do a massive group buy. Right now one person brings up seti, another guy says, "OC is better, let's do that"....I think we will get nowhere like this.

OC has a good number of positive testimonials behind it on the forums. Setipiprant does not have any. Personally I'm on board for OC or TM. I'm currently having some success with ramatroban, so I'm not interested in switching to something that no one has had any success with yet.

[KO1]

I think that we're all getting splintered in our efforts. Instead of divvying up time between OC and seti, I say we all focus on ONE molecule, whether it be seti or OC we can decide, and put together a list of suppliers that can be our supply chain and do a massive group buy. Right now one person brings up seti, another guy says, "OC is better, let's do that"....I think we will get nowhere like this.

[diffuseloser]

Can't wait to try this stuff out but won't be buying from Kane. He's milked me dry with RU already. Thanks for all the input guys this forum has really been smoking the past couple of weeks and we seem to have a lot of new options coming our way. Been interesting reading that's for sure.

[kantian]

Thanks again for your efforts sdsurfin. I'm basically going to do as you say. This forum needs a leader and some followers, so I'm happy to enlist as a follower.

When I last checked, the teamTLR website was down.

[sdsurfin]

Ok guys, but am I the only one who has no idea how to even use (mix/dose) OC or seti? I mean, it's just sorta hard to get the ball rolling and try to drive the price down when you have no idea what you're aiming for. I for one don't even know how much I would need per day/month for maintenance, much less what that would amount to cost-wise - and I might not be the only one.
Maybe it would be a good idea to eventually start a thread on OC/seti use and mixing similar to hellouser's Complete RU58841 Usage Guide(?)
And thanks to everyone for putting so much effort into this.

Just waiting on the guy to get back to us with a price still. Hang tight. When we figure it out I will start a new thread. Unless you're rich, Don't buy any of this stuff from Kane, its a rip off.