Emall to kane

[sdsurfin]

Here's what I emailed Kane, I don't suggest you guys cut and paste this, cause he'll think something weird is up, but I think this is basically what we should be asking him.



Hello, I was told that you are looking into PGD2 blockers. I have researched this matter extensively, and as a customer I would like to know if you can make Setipiprant available to buyers at a competitive price. I am aware that OC00495 is a stronger compound, but years of work by the research team at University of Pennsylvania and Dr. Cotsarellis have found that setipiprant is more active at the hair follicle, and is easier to administer (orally). Recently, Kythera pharmaceuticals announced their intention to buy the patent for setipiprant and market it for hair loss. The latest research (as well as anecdotal evidence online) suggests that PGD2 blockers, and not anti androgens like RU, are the most effective and SAFE compounds for maintaining hair. The community of balding men would be hugely indebted to you if you could sell setipirant , or at the very least OC, at competitive prices that the average guy can afford. I think that your customer base would grow quickly. I am interested in starting off by buying some OC from you if you have it available, please let me know how to go about ordering. thank you.

[yayay]

Thank's a lot for everything. I'll email them right now.

[Hairismylife]

Thanks sdsurfin!

[kantian]

Thank you sdsurfin. What's Kane's website or where do I go to find his email?

[sdsurfin]

Google anageninc.

Apparently that is the same as Kane.

[Shinobi]

first, PGD2 is a response of the body, so block it will of course brings side effects.

second, Setipiprant is under worldwide patent and the company has now signed a distribution agreement. So sell it even as research molecule, is the best way to go in jail...

Its not possible to sell a patented molecule and we not even sure its safe on long term. But to you to do illegal things i guess. There is some person who deal cocaine ;p

[joachim]

first, PGD2 is a response of the body, so block it will of course brings side effects.

second, Setipiprant is under worldwide patent and the company has now signed a distribution agreement. So sell it even as research molecule, is the best way to go in jail...

Its not possible to sell a patented molecule and we not even sure its safe on long term. But to you to do illegal things i guess. There is some person who deal cocaine ;p

nah, the world wouldn't function if rules are not broken.
rules, laws and patents are just a rough guideline for life ;-)

[Shinobi]

nah, the world wouldn't function if rules are not broken.
rules, laws and patents are just a rough guideline for life ;-)

Yes but believe me the risk is very high for the company who cheat the current official distributor. And evidence would be very easy to track and attack eventually kane pr other.

For now i just recommand to wait for the official distribution and test especially since all we have here is speculation. Other molecule has shown effective effect such as ru58841 or alternativ treatment such as baicalin

[charlie76761]

He already stocks OC and has been for a while- i purchased some as recently in Jan - just email him

[Shinobi]

He already stocks OC and has been for a while- i purchased some as recently in Jan - just email him

Stop me if im wrong, but the OC is a US patent only (means cant be sold to the US territory) and still not have a distributor agremment. The risk exist but is much more minimal than Setipiprant

[Sogeking]

He already stocks OC and has been for a while- i purchased some as recently in Jan - just email him

Hey mate can you tell me how much did you buy for what price?
Also did you start using it?

[sdsurfin]

Stop me if im wrong, but the OC is a US patent only (means cant be sold to the US territory) and still not have a distributor agremment. The risk exist but is much more minimal than Setipiprant

Yeah RU might be more legal, but who gives a shit. OC and setipip are both drugs that have been through 3 phase trials and the safety is well established. RU has never been tested for safety in humans, and fin now has warnings on the bottle saying it might permanently **** up your sex organs and brain. For me the choice is simple. I don't care about legality, I care about safety. These drugs will be legal in three years or so, and I can't wait that long. So although I feel your concerns, please don't undermine what this forum is about, which is figuring out how to use unreleased and experimental treatments. No one is gonna go to jail over this, no one cares to prosecute people trying hair drugs, and no one is gonna arrest kane, the US can't do shit about what happens in china. They forge everything over there. We must make do and build good business relationships if we're gonna fight this fight.

Also, I did a lot of research on fin and RU, and am pretty convinced that although both are bad choices, fin is worse. I don't care if it has passed trials, RU is non steroidal and fin is not, and according to many scientists fin has a much greater potential to do permanent damage. Ru may give sides, but is most probably not going to cause anything irreversible. It just doesn't function that way. No guarantees that its not bad for hair in the long run, as Im still not sure if it ends up up-regulating the androgen receptor, but I'm taking the gamble that I'll only have to use it for a couple of years, and the worst that can happen is my sex drive sucks for a bit and I lose my hair, which would happen anyway. If OC and BIM work out (or hopefully setipip), Im gonna hop off the RU for sure, but to me fin and dutasteride seem (and based on my own side effects are) the worst choice. You might get away with using them for a long time, but the potential for permanent damage is not minor. ****ing with your body's ability to make 5ar with a steroidal 5ar inhibitor is just to a good idea at all. The most that OC or setipip can do is give you a headache and maybe up regulate your PGD2 receptors, which again might be bad for hair in th along run, but that is only speculative, and again won't harm your overall health or sex organs or brain. It's just a clear road that we have to take so let's work together to make it happen. Hopefully in 5 yrs we have replicel and we can inoculate ourselves against hair loss. But we have to get there with hair.

Below is some safety info for setipiprant:



"This randomized, double-blind, placebo-controlled study was performed in two parts in healthy male subjects. In study Part A, single oral doses of up to 2000 mg setipiprant or placebo were given to sequential groups of eight subjects each. Additionally, the impact of food on the PKs was investigated in one-dose group. In study Part B, two groups of subjects received 500 or 1000 mg setipiprant or placebo b.i.d. during 5.5 days. At regular intervals, tolerability variables and plasma and urine levels of setipiprant were determined. Setipiprant was well tolerated after single- and multiple-dose administration. Headache was the most frequently reported adverse event. No treatment effect on tolerability variables was observed. After single- and multiple-dose administration, setipiprant was rapidly absorbed and followed a biphasic elimination pattern with an elimination half-life between 10 and 18 h. Steady-state conditions were reached after 2-3 days and setipiprant did not accumulate. Exposure to setipiprant was lower in the presence of food. Urinary excretion of unchanged setipiprant did not exceed 7% of the administered dose. In this entry-into-human study, setipiprant showed good tolerability and a favorable PK profile, thus warranting its development in the treatment of inflammatory disorders."