Replicel news and answers

[JayM]

Well yes but to be honest if you are going to believe their claims then you may as well take note of what they are saying in terms of longer hairloss. They are still confident it will work but would need more cells cultured and different depths of injections ect like they said. I guess it would be a good thing to point out regarding that with their updated injector which apparently is much more accurate and easy to use.

[BrianH123]

Good, that's currently my type
Of Balding so as long as I don't jump off a cliff there's a chance I get my hair back before turning 30

[JayM]

They are talking about diffuse hair loss and early receding. If you watch the video's they have posted the images they use are mainly at nw4/3 and/or with crown thinning.

[TJT]

I have DUPA and afraid that it will be hard to find the healthy hair for biopsy :\

You're right; DPA would seem to be best suited to their treatment, at least in the form they will be trialing in Phase 2. Any other form of balding would presumably require their next iteration. Why wouldn't they work on that concurrently?

[TooMuchHairWontKillYou]

I have DUPA and afraid that it will be hard to find the healthy hair for biopsy :\

[TJT]

Referring to the original post by "sdsurfin", Replicel said:

"For people with extensive baldness of many years duration, we will need to conduct a separate study. It is likely that extensive, long-term duration AGA will need different cell dosages and changes to the parameters of our injection device." They also state "our phase 2 clinical trial will be tested on people with thinning hair."

Since classic Norwood balding entails the progression of completely bald areas, it would seem that their treatment (at least in the current form which will be trialed for Phase 2) would not be effective in treating classic Norwood balding. Rather it sounds like the Phase 2 treatment would better serve diffuse patterned/unpatterned alopecia (DPA/DUPA), rather than classic Norwood balding.

This begs the question of why Replicel and/or Shiseido wouldn't conduct the subsequent study alluded to ("extensive, long-duration AGA") concurrently with their upcoming Phase 2 studies. One would assume that they actually have a very good idea of the mechanism associated with new follicle formation as a result of their treatment, at least in bald mice. The latest video from Shiseido showed a bald mouse with a "crown" of hair produced by an injection of RCH-01, so it seems silly to wait 39 months for the Phase 2 study to complete on "people with thinning hair" before tackling the fully bald problem. If they don't tackle the problem of fully bald areas, then it would seem that their solution to Norwood balding would come only years down the road.

Does anyone, especially I suppose "sdsurfin" have any input on this?

[Gerhard]

There's no reason why one should accept that the best thing we will get is a drug that will duplicate the results of a treatment from the 90s, but without sides. I use finasteride religiously, everyday, and have been using it since 2007 with no sides. There are millions upon millions of men in the same position as me, who don't get sides. And fin is not a miraculous drug, it's old and outdated, we need something better.

If Replicel is a permanent maintenance then that means it would be a 100% failsafe for those unable to take propecia.

[PatientlyWaiting]

There's no reason why one should accept that the best thing we will get is a drug that will duplicate the results of a treatment from the 90s, but without sides. I use finasteride religiously, everyday, and have been using it since 2007 with no sides. There are millions upon millions of men in the same position as me, who don't get sides. And fin is not a miraculous drug, it's old and outdated, we need something better.

[Gerhard]

It's different for everyone. My uncles took two decades to lose their hair, and it took my friend 5 years. Pretty much all men go bald eventually and in some cases they are gradually thinning their whole lives. Look at woods Allen he lost just his crown early and then stayed like that forever. Can't really predict except by looking at family. Usually you are a solid combination of your two sides, but some people get an aggressive gene or, like my brother, don't get the balding gene at all.

True that. It really is a hit or miss type thing. Personally, I'm hoping that I'm unnecessarily on propecia and my hairloss stops at a early NW3 like every male on my mother's side of the family (seriously, one of my uncles was a NW3 by 16 and hasn't lost a thing since). However, I'm nervous about my dad's side as well. I guess I'll have to wait and see. Or hope Replicel comes out with an amazing treatment to just end all worries here and now.

[sdsurfin]

It's different for everyone. My uncles took two decades to lose their hair, and it took my friend 5 years. Pretty much all men go bald eventually and in some cases they are gradually thinning their whole lives. Look at woods Allen he lost just his crown early and then stayed like that forever. Can't really predict except by looking at family. Usually you are a solid combination of your two sides, but some people get an aggressive gene or, like my brother, don't get the balding gene at all.

[Gerhard]

The main problem about Replicel is that would be very expensive treatment for most of us and it will be only in Japan, so most of people can’t afford to travel 4-5 times in Tokyo to get a treatment. And they can’t afford it to a big population, because they dont have time and sources to do that.

Im a little clueless about replicel to be honest. Does their treatment only last an incremental period of time?

RepliCel if it works it will be a complete cure , as already stated is only a matter of dosage and frequency .
Sdsurfin if you answered repicel much information to a mail congratulations you are privileged.
Normally biotechnology companies with phase 2 trials do not answer or only a very reputable journalists.
Sorry for my english

I just hope their actually capable of pushing forward and making it quickly. I fear my propecia and further hair loss.

In my book propecia is pretty much a miraculous treatment, but is has shit sides. I know people who regrew all their losses on propecia and then don't ever lose it again. Or people who maintain for a couple of decades. If something can work like that without side effects that's good enough for me. I don't care if I go bald in my 50s or 60s. Also, the people who don't respond to replicel will probably be fewer (and women can also benefit) than the people who don't respond to propecia, since replicel is cell based. I don't see a lot of need to improve on the efficacy of propecia, just to make it safe. The people who are already bald are screwed, and if I was, I would just accept it. It's going to take decades if not longer to develop a cure that grows hair on bald scalp. If you talk to hair researchers now, they will tell you that new follicle engineering is coming, but not very soon. and when it does they will need to overcome the obstacles of dealing with a bald and inhospitable scalp.

So for me, if someone comes out with a solid maintenance treatment with no sides in the next decade, that's a huge improvement. Not to mention a treatment where you don't have to keep taking something or worrying about it all the time.

True. Perhaps because I'm young I say this, but being bald in my fifties or sixties isn't overly dramatic for me. I may not even hit that age due to some medical issues, so perhaps I'm biased. If I were to live that long though, I can honestly say that at that age hair would have little impact on my life. Many people are balding at that age and it's socially accepted. At the age of 16-30 it's still pretty stigmatized. Learned that yesterday from a friend of mine who didn't know I was receding.

I think many people on this forum overestimate how quick most people lose their hair. The general consensus seems to be if you do nothing, your hair is gone in 2 years. That's simply not true, more times than not, it takes years for a hair to "die out". Even then, dut and minox combo can often bring it back to life. Many doctors suggest that they can save hair that has "died out" even around 3 years ago. Therefore, I don't think it's unreasonable to expect that treatments coming won't rejuvenate a lot of these hairs you may be losing now or in the next couple of years. I mean look at all the positive responses posted from the use of current treatments. Future treatments will be as good or better.

My initial hairloss started at 18. I quickly was knocked down to a Norwood 2.5 to 3 by the time I was 19. I went through pretty much 3 full norwoods before stabilizing and I've only been on propecia recently so I have no idea if it would have continued unabated without it. However, NW3 does run in my mother's side, but my father is a full on NW 6 or 7 so that doesn't make me feel much better. Honestly, hair can go a lot quicker than you'd expect in my experience. A guy I've seen here at college is 22 and already a NW 5. I have no idea when he started losing, but that there is a prime example. I also have a few NW 7's and a couple NW 4's.

I dont know how much it will cost, but i am only predict that rich costumers will got it in the begining, because they will need machines, people and time.

I'd let them slap my ass and call me Sprinkles to get enough money to fix my hair loss. I'm sure the average Joe can do it if they set aside enough money. My next couple of summers will be for saving up for this potential cure. However, I'm still skeptical. Until we see for sure that there's a cure I'm not gonna get too excited. I'm feeling a little pessimistic lately.

[FooFighter]

I dont know how much it will cost, but i am only predict that rich costumers will got it in the begining, because they will need machines, people and time.

[FearTheLoss]

Yeah, there is that chance, I'm hoping that doesn't happen. My loss is slow, but if replicel doesn't pan out in the next three years or so I'm probably screwed. I don't know, I put a lot of hope in this treatment, but that may be very silly. There are many questions still to be answered about it, and always delays from that company.

I think many people on this forum overestimate how quick most people lose their hair. The general consensus seems to be if you do nothing, your hair is gone in 2 years. That's simply not true, more times than not, it takes years for a hair to "die out". Even then, dut and minox combo can often bring it back to life. Many doctors suggest that they can save hair that has "died out" even around 3 years ago. Therefore, I don't think it's unreasonable to expect that treatments coming won't rejuvenate a lot of these hairs you may be losing now or in the next couple of years. I mean look at all the positive responses posted from the use of current treatments. Future treatments will be as good or better.

[sdsurfin]

Not to be rude or anything. But I seen alot of posts from you and the fact you do not respond well on propecia. Isn't the chance big for you that you have lost your hair before replicel launches? I mean minox mostly work for 1 top 2 years before you loose all of what it remained in a brutal shedd . Are you using anything else except minox like treatments?

Yeah, there is that chance, I'm hoping that doesn't happen. My loss is slow, but if replicel doesn't pan out in the next three years or so I'm probably screwed. I don't know, I put a lot of hope in this treatment, but that may be very silly. There are many questions still to be answered about it, and always delays from that company.

[Hairismylife]

In my book propecia is pretty much a miraculous treatment, but is has shit sides. I know people who regrew all their losses on propecia and then don't ever lose it again. Or people who maintain for a couple of decades. If something can work like that without side effects that's good enough for me. I don't care if I go bald in my 50s or 60s. Also, the people who don't respond to replicel will probably be fewer (and women can also benefit) than the people who don't respond to propecia, since replicel is cell based. I don't see a lot of need to improve on the efficacy of propecia, just to make it safe. The people who are already bald are screwed, and if I was, I would just accept it. It's going to take decades if not longer to develop a cure that grows hair on bald scalp. If you talk to hair researchers now, they will tell you that new follicle engineering is coming, but not very soon. and when it does they will need to overcome the obstacles of dealing with a bald and inhospitable scalp.

So for me, if someone comes out with a solid maintenance treatment with no sides in the next decade, that's a huge improvement. Not to mention a treatment where you don't have to keep taking something or worrying about it all the time.

What's your opinion that nothing will regrow hair based on?
Bim, Sm target at regrowth, minox is already here, though, has sides, and the antiandrogen and pgd2 inhibitor can help in certain extent, not to mention Pilofocus.
Your comment has no ground and just based on your personal preference because you are a Nw 2~3.