Replicel news and answers

[TJT]

Referring to the original post by "sdsurfin", Replicel said:

"For people with extensive baldness of many years duration, we will need to conduct a separate study. It is likely that extensive, long-term duration AGA will need different cell dosages and changes to the parameters of our injection device." They also state "our phase 2 clinical trial will be tested on people with thinning hair."

Since classic Norwood balding entails the progression of completely bald areas, it would seem that their treatment (at least in the current form which will be trialed for Phase 2) would not be effective in treating classic Norwood balding. Rather it sounds like the Phase 2 treatment would better serve diffuse patterned/unpatterned alopecia (DPA/DUPA), rather than classic Norwood balding.

This begs the question of why Replicel and/or Shiseido wouldn't conduct the subsequent study alluded to ("extensive, long-duration AGA") concurrently with their upcoming Phase 2 studies. One would assume that they actually have a very good idea of the mechanism associated with new follicle formation as a result of their treatment, at least in bald mice. The latest video from Shiseido showed a bald mouse with a "crown" of hair produced by an injection of RCH-01, so it seems silly to wait 39 months for the Phase 2 study to complete on "people with thinning hair" before tackling the fully bald problem. If they don't tackle the problem of fully bald areas, then it would seem that their solution to Norwood balding would come only years down the road.

Does anyone, especially I suppose "sdsurfin" have any input on this?

[TooMuchHairWontKillYou]

I have DUPA and afraid that it will be hard to find the healthy hair for biopsy :\

[TJT]

I have DUPA and afraid that it will be hard to find the healthy hair for biopsy :\

You're right; DPA would seem to be best suited to their treatment, at least in the form they will be trialing in Phase 2. Any other form of balding would presumably require their next iteration. Why wouldn't they work on that concurrently?

[JayM]

They are talking about diffuse hair loss and early receding. If you watch the video's they have posted the images they use are mainly at nw4/3 and/or with crown thinning.

[BrianH123]

Good, that's currently my type
Of Balding so as long as I don't jump off a cliff there's a chance I get my hair back before turning 30

[JayM]

Well yes but to be honest if you are going to believe their claims then you may as well take note of what they are saying in terms of longer hairloss. They are still confident it will work but would need more cells cultured and different depths of injections ect like they said. I guess it would be a good thing to point out regarding that with their updated injector which apparently is much more accurate and easy to use.

[dutchguyhanging]

well if this thing works, i am willing to pay 50grand without even blink of an eye. money is not an object when it comes to hairloss. and trust me hollywood stars, soccer players....etc are willing to pay millions... just prove that it works!!! no one is here worrying about paying 50grand or visiting tokyo 10times a year.. no one....

[hellouser]

well if this thing works, i am willing to pay 50grand without even blink of an eye. money is not an object when it comes to hairloss. and trust me hollywood stars, soccer players....etc are willing to pay millions... just prove that it works!!! no one is here worrying about paying 50grand or visiting tokyo 10times a year.. no one....

Hollywood stars could have funded and cured this disease years ago had they given Dr. Lauster enough funding. Whatever, nobody cares about baldness.

[dutchguyhanging]

hello, i know you. dont get me wrong but sometimes u r being unstable and now ur having one of those tantrum. This is business and money talks.. show me the cure, tomorrow i will bring you billions. as simple as it is. have you ever thought that we have been combating with this disease over 2000 years ? yeah since mankind...
what makes you sure throwing few millions to Dr. Lauster would guarantee u the cure. I am working in one of big pharma companies and i put my ass on the line and say that money is the LAST thing you worry about if you ve shown the results.

trust me there are people all over the globe just looking for investment opportunities. these guys have billions of euros and they are scanning every bit of the corner, leaving no stone unturned to just find an opportunity... come on man.. be realistic and dont say people dont care about baldness because they do because whomever finds it he/she would be one of the richest guys

[TJT]

hello, i know you. dont get me wrong but sometimes u r being unstable and now ur having one of those tantrum. This is business and money talks.. show me the cure, tomorrow i will bring you billions. as simple as it is. have you ever thought that we have been combating with this disease over 2000 years ? yeah since mankind...
what makes you sure throwing few millions to Dr. Lauster would guarantee u the cure. I am working in one of big pharma companies and i put my ass on the line and say that money is the LAST thing you worry about if you ve shown the results.

trust me there are people all over the globe just looking for investment opportunities. these guys have billions of euros and they are scanning every bit of the corner, leaving no stone unturned to just find an opportunity... come on man.. be realistic and dont say people dont care about baldness because they do because whomever finds it he/she would be one of the richest guys

This. The reason Lauster or anyone else couldn't come up with sufficient funding is because the science behind it wasn't making a strong enough case to draw in the investors. Nobody will throw money at it unless they think that money will make them more money; that's a basic truth. Replicel made a strong enough case and Shiseido invested. At this point baldness is being attacked from all angles between Replicel/Shiseido (follicle rehabilitation angle) and Tsuji labs/Replicel/Shiseido/others (follicle neogenesis angle). It's really only a matter of time at this point, and the advances are coming faster than ever. Some will be quick to point out that it's been said many times before, but that's how science and engineering work; it's an exponential graph of achievement and understanding, and just like a puzzle, as more pieces of the puzzle come together, the remaining pieces come together increasingly quickly. Being a "negative Nancy" brings nothing to the table, and you can bet your ass that the skilled people dedicating their careers to this are trying their hardest given that the cure would assure them of professional and financial success. Stay positive, it's almost cracked!

[baldybald]

This. The reason Lauster or anyone else couldn't come up with sufficient funding is because the science behind it wasn't making a strong enough case to draw in the investors. Nobody will throw money at it unless they think that money will make them more money; that's a basic truth. Replicel made a strong enough case and Shiseido invested. At this point baldness is being attacked from all angles between Replicel/Shiseido (follicle rehabilitation angle) and Tsuji labs/Replicel/Shiseido/others (follicle neogenesis angle). It's really only a matter of time at this point, and the advances are coming faster than ever. Some will be quick to point out that it's been said many times before, but that's how science and engineering work; it's an exponential graph of achievement and understanding, and just like a puzzle, as more pieces of the puzzle come together, the remaining pieces come together increasingly quickly. Being a "negative Nancy" brings nothing to the table, and you can bet your ass that the skilled people dedicating their careers to this are trying their hardest given that the cure would assure them of professional and financial success. Stay positive, it's almost cracked!

Well said. An example for that is aderans. They did not show a good work and lack of evidence which made the Japanese company stops funding. Replicel shows the mechanism of the work and they understand hair loss much much more than aderans. At the beginning replicel found some problems but according to their videos they fixed the problems. I think they can be the cure or at least you will get half of your hair and that is only my opinion.

[baldybald]

Replicel said they cannot regrow hair in a scar which is understandable, but then they said they may also cannot grow hair in a slick bald head that what makes me confused. Guys correct me if am mistaken.

[Trouse5858]

Technology (and really, just computing capabilities) advance at an exponential rate, not medical discoveries that turn into treatments. Shit, if your talking specifically about baldness, it hasn't even increased at a linear rate let alone exponentially. There has never been a non-surgical treatment option that was studied, targeted for, and subsequently released to halt MPB. The only two treatment options that exist are laughably archaic and were completely lucky side effects of other treatments. That's just something to consider before we launch into the 'Scientific discovery is exponential' hyperbole.

[TJT]

Replicel said they cannot regrow hair in a scar which is understandable, but then they said they may also cannot grow hair in a slick bald head that what makes me confused. Guys correct me if am mistaken.

They DO expect to grow hair on a slick bald head; read point 3 of the initial post in this thread. Apparently the Phase 2 data will help them identify the correct dosing and injection depth for the creation of new follicles, IF it turns out that the "migration of DSCs" method doesn't already create new follicles as trialed in Phase 2.

[rdawg]

Technology (and really, just computing capabilities) advance at an exponential rate, not medical discoveries that turn into treatments. Shit, if your talking specifically about baldness, it hasn't even increased at a linear rate let alone exponentially. There has never been a non-surgical treatment option that was studied, targeted for, and subsequently released to halt MPB. The only two treatment options that exist are laughably archaic and were completely lucky side effects of other treatments. That's just something to consider before we launch into the 'Scientific discovery is exponential' hyperbole.

Ive been on this forum since 2011-12, I can tell you i've never seen a time where almost every other week a company is announcing a phase II, finishing a phase II etc. like it is these days.

3-4 years ago we had histogen and aderans(which was never promising) going through trials, that's it, everything else was theories and speculation.

now we have SM, CB, SETI, REPLICEL, BIM, Histogen, Follicum all moving forward with the next stage or getting very close.

to say it hasn't accelerated in the past few years is just ignoring the past, it was never this good and honestly everytime I come in here there are announcements about new products, techniques etc. being studied, which was never the case a few years ago. This place was beyond depressing, it felt like it was get an HT and take Fin/DUT or lose it all which are terrible options, I remember coming here for months and literally zero announcements would occur, just far reaching greymarket theories.

we are much, much closer than before and I've never been more excited, the results aren't quite tangible yet, but you tell it's getting close, and it's only a matter of months, not years, that we will get an announcement of a product that really helps hairloss, which is something to look forward to.

Replicel is a very promising treatment, and in the nearer future so is BIM(closest to release), SETI(partnered with BIM) as well as CB and SM.