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I hate to burst everyone's bubble, but this drug is not going to be cool. People who take antihistamines for long periods of time go through really horrible withdrawals. My dad is a doctor and this is why he does not prescribe them long term. Taking this drug for hair loss might work, but it is going to wreak havoc on your body long term when you try to stop. There is simply no miracle drug for baldness, cell treatments are our only hope, and without something to stop PGD2 or DHT, things like replicel will only have a limited effect. The withdrawal stuff is not speculation, you can't just suppress your histamines forever and expect your body not to react. I'm honestly surprised kythera is pursuing this, although they probably don't care about long term effects. feeling bummed.
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I hate to burst everyone's bubble, but this drug is not going to be cool. People who take antihistamines for long periods of time go through really horrible withdrawals. My dad is a doctor and this is why he does not prescribe them long term. Taking this drug for hair loss might work, but it is going to wreak havoc on your body long term when you try to stop. There is simply no miracle drug for baldness, cell treatments are our only hope, and without something to stop PGD2 or DHT, things like replicel will only have a limited effect. The withdrawal stuff is not speculation, you can't just suppress your histamines forever and expect your body not to react. I'm honestly surprised kythera is pursuing this, although they probably don't care about long term effects. feeling bummed. -
All drugs have potential side effects. However, applied topically they could be minimal. The only sure-fire solution will be gene editing, but that won't be ready for clinical application within our life times. The commercialisation of the PGD2 work is still an exciting prospect no matter which way you look at it. -
This is why we should be pushing kythera to make this a topical. Im not sure that will make a difference in this case though, even if it's just in your scalp, a withdrawal from it could cause havoc just on the scalp. Blocking receptors is just a mess of a game, same with propecia, you can't put a roadblock on your body for too long without consequences. gene editing really is the only cure. engineered follicles could be something but i doubt they will thrive in balding scalp, and are also far off. best to just get used to this.Comment
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but they are not decreasing PGD2, they are blocking the receptors that it latches onto. reducing PDG2 levels in balding scalp would be great but that's not what this does. when you quit taking it the receptors will be overloaded and withdrawal will ensue. hopefully this receptor is more specific and less related to itch etc than the H1 receptor that zyrtec targets. i can see MPB itch becoming horrendous after taking this for a long time and then stopping.Comment
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I was just about to say this myself. I've been assuming that Setipriprant is going to follow the same method as propecia in the sense that it will lower the prostaglandin levels. I was going to email them, but it seems you can only reach them via telephone if you're not a healthcare professional.Comment
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If you check out page 8 of the presentation, it shows PGD2's relation to hair loss, also its relation to DHT. PGD2 is way downstream, and is actually involved in hair cycling. This would get to the source of the problem, rather than partially blocking a natural male hormone.Comment
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Not only that, but 5ar inhibitors don't block all the DHT, and testosterone supposedly binds to androgen receptors too (albeit much less). There are still hormones floating around that can active this chain of events even on 5ar inhibitors. If you stop it further down the chain with PDG2 you avoid this.Comment
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It has a lot of potential but yes there will be sides. There is no magic internal drug without sides, but if they are minimal most people will use it. What alternative do you have? You will be waiting a decade for anything safer/betterComment
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