Setipiprant

[chongmet]

According to my research, and my research only, I have found out that Setipiprant reduces PGD2 levels, which is higher in balding people's scalp. Therefore, Seti will not give regrowth. It's main purpose is to STOP balding.

Minox showed regrowth because it increases PGE1, which is shown to regrow hair. That is why regrowth was shown as a side effect.

I have been doing extensive research, and found that CD-200 and CD-34 are an important piece of the puzzle to reversing hairloss. Do you happen to know what products can be used concerning that? Thanks Swoop.

It's strange. As far as I know, Seti blocks one of the receptors of PGD2. If it is true, then it has nothing to do with PGD2 levels, but just making those PGD2's unable to connect , hence preventing the chain reaction.
But 1 thing is sure - Seti's goal is not regrow hair, but maintaining.

[JSmith120]

This is not true. You are not always blind. You can look for observational evidence in vivo. Setipiprant is a selective DP2 antagonist. So the first question you could ask yourself; "Are there other selective DP2 antagonists?"

That would give you an answer; "Yes there are many selective DP2 antagonists in clinical trials and some are even close to be released into the market.".

So that would mean that these other compounds would need to show evidence of regrowth of hair because their primary intention is all the same (selectively antagonizing the DP2 receptor). Yet none of the clinical trials showed this as a side effect. Furthermore we haven't even seen a case study whatsoever of evidence of regrowth of hair with DP2 antagonists.

The thing is many people suffer from androgenetic alopecia. This means that many people are automatically a test subject for it unwillingly in clinical trials that are not even related to hair growth. That's the beauty of it. That's what happened with minoxidil too. Hair growth showed up as an side effect. Other potassium channel openers like like minoxidil, for instance diazoxide and pinacidil have shown to induce hair growth too. Hair regrowth doesn't go by unnoticed.

This will actually tell you immediately that DP2 antagonists like setipiprant won't regrow your hair pretty much. Why? Well just like I said because the evidence would already been shown through these other compounds that have the same biological activity as setipiprant. This is just logical thinking and how science works. So this isn't being blind or speculative. You can already be pretty damn sure of this.

We should clap our hands and be extremely lucky if this will actually even maintain hair or even somewhat approach a treatment like finasteride in terms of effectiveness. At least such is my opinion.

According to my research, and my research only, I have found out that Setipiprant reduces PGD2 levels, which is higher in balding people's scalp. Therefore, Seti will not give regrowth. It's main purpose is to STOP balding.

Minox showed regrowth because it increases PGE1, which is shown to regrow hair. That is why regrowth was shown as a side effect.

I have been doing extensive research, and found that CD-200 and CD-34 are an important piece of the puzzle to reversing hairloss. Do you happen to know what products can be used concerning that? Thanks Swoop.

[Swooping]

I just want to see a study with results on what one of these things like seti can do in humans. How well does it prevent hair loss? Does it regrow anything? Right now we are completely blind there is no info on any real human results

This is not true. You are not always blind. You can look for observational evidence in vivo. Setipiprant is a selective DP2 antagonist. So the first question you could ask yourself; "Are there other selective DP2 antagonists?"

That would give you an answer; "Yes there are many selective DP2 antagonists in clinical trials and some are even close to be released into the market.".

So that would mean that these other compounds would need to show evidence of regrowth of hair because their primary intention is all the same (selectively antagonizing the DP2 receptor). Yet none of the clinical trials showed this as a side effect. Furthermore we haven't even seen a case study whatsoever of evidence of regrowth of hair with DP2 antagonists.

The thing is many people suffer from androgenetic alopecia. This means that many people are automatically a test subject for it unwillingly in clinical trials that are not even related to hair growth. That's the beauty of it. That's what happened with minoxidil too. Hair growth showed up as an side effect. Other potassium channel openers like like minoxidil, for instance diazoxide and pinacidil have shown to induce hair growth too. Hair regrowth doesn't go by unnoticed.

This will actually tell you immediately that DP2 antagonists like setipiprant won't regrow your hair pretty much. Why? Well just like I said because the evidence would already been shown through these other compounds that have the same biological activity as setipiprant. This is just logical thinking and how science works. So this isn't being blind or speculative. You can already be pretty damn sure of this.

We should clap our hands and be extremely lucky if this will actually even maintain hair or even somewhat approach a treatment like finasteride in terms of effectiveness. At least such is my opinion.

[baldybald]

I'm not sure if it's the same situation. But anyway, even if it is, Fin is something we already know by clinical trials the right dosage. In Seti, we don't know it yet, so it might be better to use it topically, as for now (for saving reasons)

Yes I agree for saving reason. Again minoxidil is more effective oraly than topically but it is not safe at all. In general, most of time oraly is more effective. Just my opinion.

[baldybald]

I'm not sure if it's the same situation. But anyway, even if it is, Fin is something we already know by clinical trials the right dosage. In Seti, we don't know it yet, so it might be better to use it topically, as for now (for saving reasons)

Yes I agree for saving reason. Again minoxidil is more effective oraly than topically but it is not safe at all. In general, most of time oraly is more effective. Just my opinion.

[chongmet]

Not true. It is the same as finasteride, use it oraly or topically?

I'm not sure if it's the same situation. But anyway, even if it is, Fin is something we already know by clinical trials the right dosage. In Seti, we don't know it yet, so it might be better to use it topically, as for now (for saving reasons)

[baldybald]

Users in forums say that taking it orally wasting 50% of the substance. I'm sure Kythera can solve it if they just find out the right dosage for taking it orally. But I'm not sure if we can afford it right now (economically). Then we might want to use it topically in order to not waste much of the substance. But am not sure about it.

Not true. It is the same as finasteride, use it oraly or topically?

[baldybald]

Users in forums say that taking it orally wasting 50% of the substance. I'm sure Kythera can solve it if they just find out the right dosage for taking it orally. But I'm not sure if we can afford it right now (economically). Then we might want to use it topically in order to not waste much of the substance. But am not sure about it.

Not true. Timid the same as finasteride, use it oraly or topically?

[chongmet]

Still using oraly is more effective and recommend in their website

Users in forums say that taking it orally wasting 50% of the substance. I'm sure Kythera can solve it if they just find out the right dosage for taking it orally. But I'm not sure if we can afford it right now (economically). Then we might want to use it topically in order to not waste much of the substance. But am not sure about it.

[baldybald]

You'll find out pretty soon.

Still using oraly is more effective and recommend in their website

[hellouser]

I just want to see a study with results on what one of these things like seti can do in humans. How well does it prevent hair loss? Does it regrow anything? Right now we are completely blind there is no info on any real human results

You'll find out pretty soon.

[burtandernie]

I just want to see a study with results on what one of these things like seti can do in humans. How well does it prevent hair loss? Does it regrow anything? Right now we are completely blind there is no info on any real human results

[Farkhairloss]

Expect delays, as per usual.

Hellouser looking forward to your updates. Also what is the story behind the guy from Switzerland with the t3mple regrowth? His posts keep getting d3leted. He mentions you on his blog. Is he legit?

[Canuck]

I'll give you guys an update closer to the end of the month.

I mostly lurk but really looking forward to your update, hellouser!

[bibi]

Don't forget that there is more than 10 Crth2 inhibitor(like OC459) in trial already for asthma.
Asthma is the reason that Crth2 inhibitors will come onto market pretty quickly so I would not be worried that much about pipeline etc.