Kythera Acquires Rights to PGD2 Blocking Setipriprant for New Hair Loss Treatment

[PatientlyWaiting]

I've been here 5 years, but have actually been following hair loss treatments since 2006. Just because some one signed up on a baseball forum in 2010, doesn't rule out that they have been watching baseball since 1993.

And to the poster who listed me as a negative member, i've done all I had to do to fight hairloss. FUE, fin, rogaine everyday, tried other crap for 9 years. Also, I come here like how many times a year? 3-4 times? How am I always crying?

[It's2014ComeOnAlready]

I'm also hoping bim turns out to be good, and becomes available sometime relatively soon. Gotta cut down big time on the fin.

[Gerhard]

I have been in contact with Kythera. They did confirm that they plan to go straight into a phase II study at the end of 2015/ or beginning of 2016 (so probably early-mid 2016 with how things work). Furthermore, if the results are positive they will be immediately going into a large phase III study.

Does anyone know if this could be released in Asia immediately after phase II?

Here's to hoping for positive results. The science is there, hopefully Cots' work wasn't for nothing because his credibility is riding on this as his discoveries are being put into trial.

This is both good and bad news. Good in the sense that they will definitely push forward with it. Bad in that we have yet another year to wait. I will tag this thread for a later date. Waiting around for updates would be exasperating. I want a cure, but constantly checking for one will drive me insane. For now all I can do is nibble at my propecia, hope my hair stays, and lift. Hopefully Cotsarelis pulls through - both for our sake and his own.

[It's2014ComeOnAlready]

I have been in contact with Kythera. They did confirm that they plan to go straight into a phase II study at the end of 2015/ or beginning of 2016 (so probably early-mid 2016 with how things work). Furthermore, if the results are positive they will be immediately going into a large phase III study.

Does anyone know if this could be released in Asia immediately after phase II?

Here's to hoping for positive results. The science is there, hopefully Cots' work wasn't for nothing because his credibility is riding on this as his discoveries are being put into trial.

Excellent news. I had hoped it would be quicker, but this is good too. Hopefully they can file the NDA approval half way through phase 3, granting a somewhat earlier release.

[FearTheLoss]

I have been in contact with Kythera. They did confirm that they plan to go straight into a phase II study at the end of 2015/ or beginning of 2016 (so probably early-mid 2016 with how things work). Furthermore, if the results are positive they will be immediately going into a large phase III study.

Does anyone know if this could be released in Asia immediately after phase II?

Here's to hoping for positive results. The science is there, hopefully Cots' work wasn't for nothing because his credibility is riding on this as his discoveries are being put into trial.

[Trouse5858]

How come you're not on ru anymore? Are any of you guys on steady ru with success? Thinking of trying it out.

I'm about 2 months into RU with what I'd say is moderate success. I've taken before pictures so when I finish up in about a month, I'll be able to (hopefully) assess how much regrowth there has been but there's definitely been at least a little. Slight gyno on right nipple but I'll add to the RU thread with more details when I've run out of this batch.

[FearTheLoss]

has anyone attempted to contact them in hopes of being a part of their POC trial?

[Dan26]

bro how did your HT go?

[sdsurfin]

M

You're an idiot. I don't spend my time crying about hairloss you Neanderthal. I'm in the camp that believes rubbing Chinese powders on your head in hopes to maintain a few follicles is not the route one should take. Yes, it's experimental and I have used RU personally, but that isn't the answer and comes with risk like anything in this category, but I digress.

My greater point is having legit approved treatments coming to market and enough with the false promises and press releases. People go on this section of the forum because there is nothing else outside of a Propecia and Minox that can help with their situation. This section is in existence for those willing to rub experimental Chinese powders on their head in hope that any studies conducted on the substance (if any) can have any impact on their hair.

We have no viable option now then we did decades ago to treat this condition. Period.

You can post about any herb and powder you want on this thread for home mixture. I wouldn't get mad at you, but I would shake my head. I frequent this forum for information on ANY potential legit treatments with potential releases to market...if that ever happens.

Nobody is crying here. I know what's reality and I sure as hell know what's available to treat my hairloss at the moment..and it's nothing in this section.

How come you're not on ru anymore? Are any of you guys on steady ru with success? Thinking of trying it out.

[StayThick]

M

well look at RU, it is really big now and readily available, and thats all a result of forums like this. So really that is what we can try and do with SET, or other such experimental treatments.

BTW, those negative posters like PatientlyWaiting, LongWayHome, StayThick, Hairismylife, why are you even in the experimental forum??? All you guys do is cry about hairloss. But never try to think outside the box and try to come up with a solution or alternative. Stop focusing on the problem and focus on a solution.

sdsurfin, good on you for trying to find a solution. Maybe it will work, prob wont, but at least we are trying something instead of just crying like babies and trying to disprove every far fetched idea

You're an idiot. I don't spend my time crying about hairloss you Neanderthal. I'm in the camp that believes rubbing Chinese powders on your head in hopes to maintain a few follicles is not the route one should take. Yes, it's experimental and I have used RU personally, but that isn't the answer and comes with risk like anything in this category, but I digress.

My greater point is having legit approved treatments coming to market and enough with the false promises and press releases. People go on this section of the forum because there is nothing else outside of a Propecia and Minox that can help with their situation. This section is in existence for those willing to rub experimental Chinese powders on their head in hope that any studies conducted on the substance (if any) can have any impact on their hair.

We have no viable option now then we did decades ago to treat this condition. Period.

You can post about any herb and powder you want on this thread for home mixture. I wouldn't get mad at you, but I would shake my head. I frequent this forum for information on ANY potential legit treatments with potential releases to market...if that ever happens.

Nobody is crying here. I know what's reality and I sure as hell know what's available to treat my hairloss at the moment..and it's nothing in this section.

[StayThick]

Having been using it long enough to know, and my hair isn't too bad, so it's hard to tell.
Topical cetirizine has completely stopped my mpb itch, but it dries my whole mouth and throat out.
We mell well be ****ed with nothing new on the horizon, but the opposite could be true as well. The PGD2 pathway is definitely real, and definitely has the potential to halt hair loss. I agree nothing is going to grow hair on bald scalp, but maintaining what you have is already possible with propecia, and will be possible with better alternatives soon I think. No one knew anything about hair loss ten years ago. they now at least know the basic pathways downstream of DHT activation, and that knowledge is bound to lead somewhere. I don't remember any new drugs being trialled for MPB in the near-past except RU, which actually does work to some extent and is being used by many despite lack of approval. Cell based treatments have failed so far because they weren't quite there with their knowledge.

I'm pretty sure that anyone who can handle cetirizine (and most people can use zyrtec without major sides) or can afford ramatroban already has a better alternative to minoxidil.

I can respect your contribution to this forum and agree with majority of your points above.

Hopefully progress leads to treatments coming to fruition. That's my biggest thing. Let's see some treatments released, not press releases.

Much respect tho. I'm with you in this fight.

[kaptainjack]

I might just give cetirizine a try orally. It's available over the counter and costs next to nothing. Where I live they sell it in liquid form as well, and I wonder if it would be worth trying out topically.

[sdsurfin]

How much regrowth from Adenogen?

Having been using it long enough to know, and my hair isn't too bad, so it's hard to tell.
Topical cetirizine has completely stopped my mpb itch, but it dries my whole mouth and throat out.
We mell well be ****ed with nothing new on the horizon, but the opposite could be true as well. The PGD2 pathway is definitely real, and definitely has the potential to halt hair loss. I agree nothing is going to grow hair on bald scalp, but maintaining what you have is already possible with propecia, and will be possible with better alternatives soon I think. No one knew anything about hair loss ten years ago. they now at least know the basic pathways downstream of DHT activation, and that knowledge is bound to lead somewhere. I don't remember any new drugs being trialled for MPB in the near-past except RU, which actually does work to some extent and is being used by many despite lack of approval. Cell based treatments have failed so far because they weren't quite there with their knowledge.

I'm pretty sure that anyone who can handle cetirizine (and most people can use zyrtec without major sides) or can afford ramatroban already has a better alternative to minoxidil.

[kmit028]

well look at RU, it is really big now and readily available, and thats all a result of forums like this. So really that is what we can try and do with SET, or other such experimental treatments.

BTW, those negative posters like PatientlyWaiting, LongWayHome, StayThick, Hairismylife, why are you even in the experimental forum??? All you guys do is cry about hairloss. But never try to think outside the box and try to come up with a solution or alternative. Stop focusing on the problem and focus on a solution.

sdsurfin, good on you for trying to find a solution. Maybe it will work, prob wont, but at least we are trying something instead of just crying like babies and trying to disprove every far fetched idea

[StayThick]

You've been on here 5 years. wow. that is nothing. Your logic is flawed. Just because nothing has happened in those 5 years doesn't mean it won't. People were saint the same thing as you in the 90s, and then boom, propecia came out. it is effective, but not perfect. the next drug will also be effective, and maybe a bit more perfect. They have learned a lot about mpb in the last 5, and are now applying that knowledge. There are about 6 new treatments for AGA in the pipeline, as opposed to basically none 5 years ago. Intercytex and aderans failed because the science was not there yet, and their failure is a step along the way to a really huge stem cell fix that is still a bit off. I think you're quite wrong about not having anything else in five years though. Things do happen, just not according to our personal plans. They cured hepatitis C out of nowhere, as well as alopecia areata. You never know when something will work, and some things in trials now have a lot of promise. Your speculation that nothing is coming is no more accurate than saying "5 years". There is pretty much zero chance that nothing else will come in the next 20 years, that is just nonsense. I'm already using Adenogen from shiseido and it has equal efficacy to minox with no sides, so you're already wrong that there is nothing new. I would say that as soon as 3 years we could have a new maintenance treatment, and within 20 there will definitely be cell based therapies. If you educated yourself on the science, that becomes very clear.

Until something if/eventually hits the market then your opinion is just that..your opinion. Nothing short of minox and fin is what we have available back then and now period.

Personally, I've seen countless threads since I've been a member here of all sorts of "potential" breakthroughs, pipeline, claims, etc. Guess what? Not one has ever been released or close to being released. Not one.

I won't hold my breath for this or anything short of improvements to the hair transplant industry. That is and will remain the only viable option to get permanently bye bye hair back on your scalp even if for a limited time.

Really don't care what you believe will potentially come out either because you just join the plenty that have created hope for those desperate on this forum for anything, anything to show promise, only to still be stuck with a penis wrecking pill and a foam that ages skin.

I wish you the best.