Any news??

[Scientalk56]

I have been following this forum since 2009..(6 years)
all i can tell is that u have two options: Minoxidil and propecia..
And.. hair trasnplants.

Thats all

[hellouser]

I have been following this forum since 2009..(6 years)
all i can tell is that u have two options: Minoxidil and propecia..
And.. hair trasnplants.

Thats all

Great research progress, much success, very exciting.

[thequestion]

I think SM could really be big time. They did their phase 1 trial in Australia and now they went into a MASSIVE phase II trial in the US, only recruiting patients that are high norwoods, and they are bringing results out in a timely manner. I don't think a company could have this big of a phase II trial with high norwoods if they didn't have something that showed great promise in phase I. Plus, the WNT pathway has backing.

I am not familiar with SM. Can you guys please let me know what company this is? Thanks.

[Jasari]

In the next 5 years? Probably a slight improvement on Fin and Minox. Norwood 4 and under might have something to give decent coverage.

[burtandernie]

There are not a lot in terms of concrete results in the last 20 years so I think its fine to have a healthy dose of skepticism until we see some actual real studies or results showing something works for certain.

[tedwuji]

In the next 5 years? Probably a slight improvement on Fin and Minox. Norwood 4 and under might have something to give decent coverage.

What improvement on Fin? I dont see how. Fin is our miracle drug. Id expect hair cloning before an improvement in oral DHT inhibitors. Especially with as much proven safety as Fin w/ it's 25 year track record with the FDA. Maybe we'll see improved topicals over Minox... thats about it.

[Jasari]

What improvement on Fin? I dont see how. Fin is our miracle drug. Id expect hair cloning before an improvement in oral DHT inhibitors. Especially with as much proven safety as Fin w/ it's 25 year track record with the FDA. Maybe we'll see improved topicals over Minox... thats about it.

I've been reading these sites since I was 18 & I'm 28 now. I've seen the cycle of company bankruptcy numerous times.

That being said, we are progressing. Cell based research is exponential. What took 10 years to learn in 1980 takes a fraction of the time in 2015.

2020 will likely be a better landscape for sufferers but I wouldn't bank on it. People would be wise to save for FUE and at least get on Minox in the meantime.

[tedwuji]

I've been reading these sites since I was 18 & I'm 28 now. I've seen the cycle of company bankruptcy numerous times.

That being said, we are progressing. Cell based research is exponential. What took 10 years to learn in 1980 takes a fraction of the time in 2015.

2020 will likely be a better landscape for sufferers but I wouldn't bank on it. People would be wise to save for FUE and at least get on Minox in the meantime.

what about Fin?

[Jasari]

what about Fin?

I dont think well see an improvement on DHT inhibitors all Fin. Technology has surpassed that - It will be a cell based treatment to halt hair loss.

Personally Fin is barely maintenance for me so hopefully an improvement comes soon.

[tedwuji]

In the next 5 years? Probably a slight improvement on Fin and Minox. Norwood 4 and under might have something to give decent coverage.

ah, ok. thought u said we will see improved Fin above.

[Jasari]

ah, ok. thought u said we will see improved Fin above.

I meant an improvement on fins primary objective: halting hair loss. My bad.

[sdsurfin]

The following study (it's not new) is why this forum is dumb, and we should all just learn to deal. After 30 months of balding, follicles become fibrotic and basically reviving them is a lost cause. Anyone who has lost hair and is expecting replicel or CB or SM or any of these things to bring their hair back is delusional. The fact that Replicel touts their product as a possible cure is ridiculous and gives false hope. there's no way DSC cells are going to be able to migrate to follicles that are fibrotic and turn things around.




Konstantinova N, Korotkii N.G, Sharova N, Barhunova E, Gaevski D. Nioxin Research Inc, AtlantaIrreversibility of hair follicle changes after 30 months of Androgenetic Alopecia.
, USA Moscow Medical University
We studied horizontal and vertical biopsy from 15 caucasian 24-41 year old males diagnosed with bitemporal recession Androgenetic Alopecia (AA) for 1.5 –18 years (average 7.4 years). All 15 biopsies were stained with H&E, Van Gieson and with other collagen specific stainings. 1. Eleven pts with AA longer than 3 years had perifollicular fibrosis - collagen fibers were compact and formed a small scar-like formation around each anagen hair follicle(HF). Two patients - 33 year old with 18 month AA and 23 year old with 20 month AA did not have these hair follicle changes. Two 26-year-old patients with 30 and 36 month AA respectively were found to have some not so severe collagen fiber changes. 2. Infundibulum of HF dilatated 124-192 mm and most of them covered with keratinazed plug lacking normal hair shaft growth. 3. Decreased number of hair follicles 1.75-2,45 per sq. mm from 3.5-5 per sq. mm in control group. 4. None of anagen HF was situated in subcutaneous fat. We showed a correlation between length of the AA and severity/ thickness of perifollicular fibrosis. The result of this study is that any treatment of AA is recommended to start earlier than 30 months from first signs of AA. This should prevent irreversible collagen changes associated with “fibrotic incapsulation” of most anagen HF in involved areas, which usually leads to loss of normal blood supply, innervation, and subsequent miniaturization and prevention of hair from normal cycling.

[tedwuji]

The following study (it's not new) is why this forum is dumb, and we should all just learn to deal. After 30 months of balding, follicles become fibrotic and basically reviving them is a lost cause. Anyone who has lost hair and is expecting replicel or CB or SM or any of these things to bring their hair back is delusional. The fact that Replicel touts their product as a possible cure is ridiculous and gives false hope. there's no way DSC cells are going to be able to migrate to follicles that are fibrotic and turn things around.




Konstantinova N, Korotkii N.G, Sharova N, Barhunova E, Gaevski D. Nioxin Research Inc, AtlantaIrreversibility of hair follicle changes after 30 months of Androgenetic Alopecia.
, USA Moscow Medical University
We studied horizontal and vertical biopsy from 15 caucasian 24-41 year old males diagnosed with bitemporal recession Androgenetic Alopecia (AA) for 1.5 –18 years (average 7.4 years). All 15 biopsies were stained with H&E, Van Gieson and with other collagen specific stainings. 1. Eleven pts with AA longer than 3 years had perifollicular fibrosis - collagen fibers were compact and formed a small scar-like formation around each anagen hair follicle(HF). Two patients - 33 year old with 18 month AA and 23 year old with 20 month AA did not have these hair follicle changes. Two 26-year-old patients with 30 and 36 month AA respectively were found to have some not so severe collagen fiber changes. 2. Infundibulum of HF dilatated 124-192 mm and most of them covered with keratinazed plug lacking normal hair shaft growth. 3. Decreased number of hair follicles 1.75-2,45 per sq. mm from 3.5-5 per sq. mm in control group. 4. None of anagen HF was situated in subcutaneous fat. We showed a correlation between length of the AA and severity/ thickness of perifollicular fibrosis. The result of this study is that any treatment of AA is recommended to start earlier than 30 months from first signs of AA. This should prevent irreversible collagen changes associated with “fibrotic incapsulation” of most anagen HF in involved areas, which usually leads to loss of normal blood supply, innervation, and subsequent miniaturization and prevention of hair from normal cycling.

better growth stimulators such as BIM, an improved transplantion technique such as PiloFocus or all-out hair cloning would be possible and viable improvements. keeping an eye out for these things or something i have forgotten to mention isn't dumb or delusional. i politely disagree with you.

[sdsurfin]

better growth stimulators such as BIM, an improved transplantion technique such as PiloFocus or all-out hair cloning would be possible and viable improvements. keeping an eye out for these things or something i have forgotten to mention isn't dumb or delusional. i politely disagree with you.

improved transplantation is always going to still be thin. growth agents might help for a while, but eventually DHT will still wreak havoc. And all out cloning will be a cure in the far future, but then only when they figure out how to make the scalp more hospitable to new follicles, which they still haven't figured out how to make. All in all yeah maybe in 2040 there might be some real hope of a cure on the horizon, but for the next couple decades its dumb to think about it.

[tedwuji]

improved transplantation is always going to still be thin. growth agents might help for a while, but eventually DHT will still wreak havoc. And all out cloning will be a cure in the far future, but then only when they figure out how to make the scalp more hospitable to new follicles, which they still haven't figured out how to make. All in all yeah maybe in 2040 there might be some real hope of a cure on the horizon, but for the next couple decades its dumb to think about it.

i was losing hair 5 years ago and today i am not. maybe one day when im 45 and married ill be bald but better than being 25 and bald while single. thankful for finasteride and if there are additional things i can do to prolong hairloss on top of transplant options, then how is that dumb? i dont care if im bald when im 50.