Derivation of Hair-Inducing Cell from Human Pluripotent Stem Cells

[Swooping]

Although this is another nice development, they didnt grow any hair that pierced the skin. And that's what matters to us: it's all about growing hair that's cosmetically viable. This was merely to prove that they could grow hair follicles, on mice, albeit using human cells. And not even IPC cells but human embryo cells. Very interesting research but far from being tested on humans.

Wow Arashi you landed with both feet on the ground?

[mikes23]

Didn't the chinese solve the DP inductivity problem in the summer? And this won't be the thing to cure baldness in the next ten years. Our only chances of that is through dr jahoda, taiwanese, or dr lauster. Though I haven't read anything about the taiwanese in a long time. I think Dr lauster will be the one to cure it. As soon as he gets the hairs to grow fully functional, we can have the trials done in Japan. And the FDA will approve it since we already have 3d printed organs in use. I remember Desmond saying that dr lauster believes he will get the hairs to grow fully in the next 2 to 3 years. And this was last year when he said it. That is why I think 2016 is the make or break year. Will solve this disease eventually, but if we want it In ten years or less we need dr lauster to come through for us.

[joachim]

Sorry to put out the negative comment out here, but I actually know two of the authors of this study. As a matter of fact, one of them is my roommate. I asked them about this, they didn't even know the article would be published. They did this research years ago and everyone in the team has moved on to doing other research. According to them, the methods used to obtain the study's result are not applicable to humans.

nah, you must be kidding. years ago? iPS cells is a relative young field of research.
not applicable to humans? why? and why does the article say they are now searching for partners to try that method in humans?
one of them is really your room mate? so the whole study is bogus or what? and how come that it can be published so many years later? what's the reason for that?

[Justinian]

nah, you must be kidding. years ago? iPS cells is a relative young field of research.
not applicable to humans? why? and why does the article say they are now searching for partners to try that method in humans?
one of them is really your room mate? so the whole study is bogus or what? and how come that it can be published so many years later? what's the reason for that?

The study does say received 2012 and accepted in 2014, published in 2015. Dunno if that guy is telling the truth though.

[hellouser]

The study does say received 2012 and accepted in 2014, published in 2015. Dunno if that guy is telling the truth though.

If it was received in 2012, you can bet that it was worked on well before that.

[Justinian]

Okay, considering several articles quote the authors as saying the next step is to try it in humans and that they are seeking partnerships to do it, that guy is lying.

[hellouser]

Although this is another nice development, they didnt grow any hair that pierced the skin. And that's what matters to us: it's all about growing hair that's cosmetically viable. This was merely to prove that they could grow hair follicles, on mice, albeit using human cells. And not even IPC cells but human embryo cells. Very interesting research but far from being tested on humans.

This is only taking into account that the cells created NEW follicles. We still dont know what they could do to existing miniaturized follicles in bald scalps. Rejuvenation, perhaps?

[sdsurfin]

I doubt he is lying, i feel like that guy posts on here a lot. What I don't understand is how someone can just toss that comment out casually...
Like if your roommate is a hair researcher then why don't you enlighten us on what IS going on. And what his opinion is as far as creating DP cells from IPS cells in general. Just seems like a crazy bit of info to throw out there and not delve into it a bit more.

[sdsurfin]

http://www.utsandiego.com/news/2015/jan/26/hair-stem-cells-papillae-gnedeva-terskikh-burnham/

A lot of news outlets are on this now. It doesn't seem like this is made up. Thinning87, can you elaborate on your doubts about this? Who is your roommate? this is a really groundbreaking and important study if it is real, and you can't just throw that out there and not explain more thoroughly. This news article includes the histogen lady, and doesn't seem like it is old news.

[joachim]

I doubt he is lying, i feel like that guy posts on here a lot. What I don't understand is how someone can just toss that comment out casually...
Like if your roommate is a hair researcher then why don't you enlighten us on what IS going on. And what his opinion is as far as creating DP cells from IPS cells in general. Just seems like a crazy bit of info to throw out there and not delve into it a bit more.

exactly was i sas thinking as well.
his room mate worked on iPS cells and clustering DP cells years ago, but he throws out that comment like it's totally common and nothing special at all. this would also mean that they were years ahead of Dr. Xu which didn't succeed to create DP cells from iPS (not sure if he even tried it yet or if it's still on his roadmap)

[Tenma]

I wouldnt take too seriously this thining87 guy. he can be a bit of a troll sometimes

[NeedHairASAP]

I wouldnt take too seriously this thining87 guy. he can be a bit of a troll sometimes

He's trolling.... this is what gail naughton has to say:

The study is "interesting and scientifically important," said San Diego biotech executive Gail K. Naughton. She is chief executive of Histogen, which is developing a hair regrowth treatment. Creation of stable and functional DP cells has so far eluded researchers.

"Short term, a stable source of lab-created DP cells that are at a younger developmental age could potentially be an important screening assay to test efficacy in new hair growth treatments," Naughton said by email. "Longer term, these cells may be a treatment for baldness once safety and efficacy of the cells are conclusively shown in vivo."



To me, it sounds like she is worried this could make histogen irrelevant histogen. She is sitting around fingers crossed this doesn't pass safety and effcacy. IF it does, histogen goes bye bye.

I'm surprised they got her for comment. THis is a nice article.

http://www.utsandiego.com/news/2015/jan/26/hair-stem-cells-papillae-gnedeva-terskikh-burnham/

[walrus]

I asked them about this, they didn't even know the article would be published.

Doubtful that they had no prior knowledge. From the journals guidelines: http://www.plosone.org/static/guidelines

"All authors must approve the final manuscript before submission. PLOS ONE will contact all authors by email at submission to ensure that they are aware of the submission of the manuscript."

I have published there myself, and can confirm this is the case.

[Thinning87]

Well guys I understand your comments and that it sucks to hear what I'm saying. I myself jumped up the chair when I saw my roommate and my friend's names on that thing. The first thing I did was to start an email and a whatsapp conversation with both of them. The one that doesn't live with me guaranteed me this stuff isn't going anywhere. He gave me scientific details but I don't have a PhD in a biology related field so I didn't understand what he was saying.

I am actually going to play poker at a friend's house tomorrow night and he will be there. I will ask him personally to give me two paragraphs in English as to why this isn't going anywhere.

By the way I hope like everyone else here that he is wrong, but he was so confident about it I had to stop asking him why (especially because I wasn't understanding the reasons he was giving me anyways).

[Arashi]

Why do you say it's far? We've already seen studies using DP cells on Human skin grafted on the back of mice. There's been an escalating stream of studies exploring different approaches to this for the past two or three years. The limiting factor in all of these was the induction problem. Now it looks like we have a viable solution for that problem. Moving to some form of Human study seems like the next obvious and logical step. Are you just being guardedly pessimistic or are you aware of further technical hurdles that are yet to be overcome?

The 'induction' problem, what makes you think it's solved ? The 'induction' problem is NOT anymore the problem of generating DP's that can induce hairlike fibers. That's solved already. No, the problem is growing hair that is cosmetically viable.

Now, these researchers didnt even manage to grow hair that pierced the skin. On mice. Apart from that, they concluded: "However, the transplantation of GFP-positive BJ16 IPSC-DP cells resulted in formation of hairs with GFP-positive dermal papillae and dermal capsules albeit with much lower frequencies (1 hair out of 50) then in case of hESC-DP cells."

So, we're only interested in IPS cells of course, but their yield was only 1 hair on 50 DP's cells. So that's worse than what Jahoda already achieved some time ago.

Again, really nice work, but still so much to be done. "Thinning87" just said in the other thread it was his roommate and that it was done 5 years ago. Let's hope he's right, that would at least put us 5 year forward already