We have a vehicle for CB-03-01: VERSAPRO

[lilpauly]

How do we really know what CB does or how powerful it is from that preliminary phase 1 study? I mean the 2x 5% might give results that are a lot different. I mean I dont know how anyone knows from such a small amount of data how well it works or how powerful it is in relation to say propecia.

^ this .they are using 2x5 % for a reason.

[FearTheLoss]

First of all it's not even much more powerful than finasteride who told you that? Not even to speak of dutasteride, as that almost peaks the ceiling together with RU for example. Only castration would be better or having a super-antagonist, but CB is far from being that. So forget about CB doing a better job in terms of efficiency than the current treatments we have now. Meaning the only unique selling point of CB-03-01 would be that it is supposedly devoid of side-effects. You already believe it is actually devoid of side effects. Based on what actually?

Maintenance is already possible today with the current treatments we have, and CB isn't going to do a better job at it, it's the cold truth. Heck I'll tell you now that DUT and RU will outperform CB-03-01. RU surely is a stronger compound. The % of people with side effects with current treatments is small anyway, and while YOU might care because you are in this position. These companies don't give a damn, they only care about ROI.

Cosmo played a nice sugarcoating game with their phase 1 concept of trial too btw. Make a concept proof of trial with 1x a week CB administration, publish huge results but opt for 2x a day application of a 5% formulation in the 2nd phase LOL. Yeah, mark my words. This one isn't going to pull through . They are 10 years to late. Lovely financial games too.

You're assumptions are laughable. Phase II is just starting and you have no idea how the difference in dosing is going to play out. Furthermore, CB has other properties, i.e. anti-inflammatory, that make it a very promising compound.

[hellouser]

First of all it's not even much more powerful than finasteride who told you that? Not even to speak of dutasteride, as that almost peaks the ceiling together with RU for example. Only castration would be better or having a super-antagonist, but CB is far from being that. So forget about CB doing a better job in terms of efficiency than the current treatments we have now. Meaning the only unique selling point of CB-03-01 would be that it is supposedly devoid of side-effects. You already believe it is actually devoid of side effects. Based on what actually?

Maintenance is already possible today with the current treatments we have, and CB isn't going to do a better job at it, it's the cold truth. Heck I'll tell you now that DUT and RU will outperform CB-03-01. RU surely is a stronger compound. The % of people with side effects with current treatments is small anyway, and while YOU might care because you are in this position. These companies don't give a damn, they only care about ROI.

Cosmo played a nice sugarcoating game with their phase 1 concept of trial too btw. Make a concept proof of trial with 1x a week CB administration, publish huge results but opt for 2x a day application of a 5% formulation in the 2nd phase LOL. Yeah, mark my words. This one isn't going to pull through . They are 10 years to late. Lovely financial games too.

More than that actually. Hair loss treatments and research is a mockery of the disease itself.

[Swooping]

You're assumptions are laughable. Phase II is just starting and you have no idea how the difference in dosing is going to play out. Furthermore, CB has other properties, i.e. anti-inflammatory, that make it a very promising compound.

I already explained CB-03-01 is slightly less active than cyproterone acetate a few pages back. This is from their own study. Meaning that 100mg of cyproterone acetate will likely do the same job as CB-03-01 or probably slightly better. And we have stronger anti-androgens around than cyproterone acetate. So yes, it's not going to be anything more effective as much as you would like it to be. If you still want it to believe in it being as magical unicorn anti-androgen, that's fine. Sorry for being the boo man and providing you reality here. I'll tell you a little secret too; every anti-androgen or 5ar2 inhibitor will have anti-inflammatory properties at the hair follicle in AGA. This is extremely logical, because androgens cause inflammatory response in AGA for instance by modulating the interleukin family. So inhibiting DHT or antagonizing the androgen receptor will always lead to an anti-inflammatory response on the hair follicle. But you believed it was unique for cb-03-01 right, because cosmo shouted that?

For the small group which have side effects with the current treatments CB may be interesting yes, but for the people who are already on DUT, FIN, RU etc. and don't suffer from side effects CB won't be anything interesting. The majority doesn't suffer from side effects anyway let's be honest. I understand people with side effects though. But I seriously wouldn't count too much on CB being ever released and if it will be it won't be short term. Extremely many drugs don't pull through phase 2 and phase 3. Also keep in mind that the lack of side effects with CB-03-01 is still not proven and very optimistic. Good news is that with the rapid drug screening models, cell culture and such, advancement is going faster than ever .

[inbrugge]

I think, on the contrary, majority of people do suffer side effects on current treatments. I believe the percentage of people who get no side effects are very small. Most probably do get side effects in varying amounts, so for some it is tolerable and others it is too much and they have to quit.

You have to admit even scientifically it doesn't make much sense that one wouldn't get any side effect from DHT inhibition. At least CB has a scientific theory behind why it should be side effect free. I'm also somewhat skeptical about that claim as it sounds too good to be true, however, we will see what the outcome is.

If CB can provide what Fin and Ru promise without the side effects then it's already a great alternative. If that's the case, then I'm sure huge amounts will either switch to CB or incorporate into their regimen.

Can anyone convince us why CB is supposed to be side effect free and why we should accept this claim? If I'm convinced I might apply for the clinical trial as I'm in Texas. Can we really trust that the active chemical is converted to a harmless chemical once it enters the blood stream? What are the findings from the earlier trials and can we trust them? I mean how did Fin get released even though it has such prominent and severe side effects? Maybe those clinical trials also reputed no noticeable side effects.

[Boldy]

I think, on the contrary, majority of people do suffer side effects on current treatments. I believe the percentage of people who get no side effects are very small. Most probably do get side effects in varying amounts, so for some it is tolerable and others it is too much and they have to quit.

You have to admit even scientifically it doesn't make much sense that one wouldn't get any side effect from DHT inhibition. At least CB has a scientific theory behind why it should be side effect free. I'm also somewhat skeptical about that claim as it sounds too good to be true, however, we will see what the outcome is.

If CB can provide what Fin and Ru promise without the side effects then it's already a great alternative. If that's the case, then I'm sure huge amounts will either switch to CB or incorporate into their regimen.

Can anyone convince us why CB is supposed to be side effect free and why we should accept this claim? If I'm convinced I might apply for the clinical trial as I'm in Texas. Can we really trust that the active chemical is converted to a harmless chemical once it enters the blood stream? What are the findings from the earlier trials and can we trust them? I mean how did Fin get released even though it has such prominent and severe side effects? Maybe those clinical trials also reputed no noticeable side effects.

this is not the reality on private forums where more people open a log. it is the majority who don't have a good satisfying effect from the current treatments and seek for other options such as HT. small percentage is getting (or better to say recognizing the sides). these people who had sides with fina and ru, reported sides with CB too! if you are sensitive, your body is either braking down the chemicals less fast as it is suposed too, or you are hypochondriac. only 2 options. for the first option there are some workarounds to play on the enzymes or abc family to brake down xenobiotics (foreign substances) faster and more efficiently which results in less sides. Im studying this topic currently.

[lupero83]

someone knows that% are used in acne trial?


Experimental: Low-dose active, BID
low dose of CB-03-01, applied twice a day Drug: CB-03-01

Topical cream, applied twice a day
Experimental: Medium-dose active, BID
medium dose of CB-03-01, applied twice a dayDrug: CB-03-01

Topical cream, applied twice a day
Experimental: High-dose active, QD
high dose of CB-03-01, applied once a day
Drug: CB-03-01
Topical cream, applied once a day
Experimental: High-dose active, BID
high dose of CB-03-01, applied twice a day
Drug: CB-03-01

Topical cream, applied twice a day
Placebo Comparator: Vehicle, QD or BID
vehicle cream, applied once or twice a day

[lilpauly]

for acne i believe they are using 1%

[lupero83]

What Is The Difference Between low dose, medium dose and high dose in the clinical trial for acne?
thanks

[pagedo]

Well I just wasted $400. God this is disappointing.

I just want to confirm - as did a previous poster - with everyone here that Versapro is not dissolving the CB powder. The active ingredient was sourced from Kane, and the Versapro cream base was purchased at a local apothecary. I used the compounding method with two spatulas and a slab. Kept at it for about 30 min and I could notice small and large clumps of the powder. I added about 1ml of ethanol in to see if it would help the mixture dissolve the CB but I could still see and feel powder in between my finger tips when I scooped it up. I tried to make a 5% solution with about 20g of Versapro.

I'll leave it overnight to see if it needs more time.

[lilpauly]

Yes man lothar used and it will not work !!! The vehicle is shit ! Cb I repeat is not worth it

[lilpauly]

lothar: Versapro is another crappy vehicle. I bought it and tested it. Cb isn't soluble in it and it isn't soluble when heated to the vehicle's melting point. Maybe if you dissolve the CB in PG first but even then, the vehicle is irritating and caused shedding.

[pagedo]

The author should have cautioned us about the solubility of VersaPro before making such a grand thread.

[lilpauly]

cosmo is using 5% 2x day in a gel.

[Thinn]

I personally still really hope this comes out. If there was a solid replacement for Finasteride without the side effects, I'd be thrilled, and I think a lot of guys (and women!) would be too. Finasteride gave me terrible side effects which took months to go away after the last time I used it. Thankfully I'm mostly back to normal but it was a very scary experience. I flushed the rest of the pills down the toilet and I'm never touching it again.

On the other hand, if this stuff came out and was side effect free (at least on the endocrine system), and it was at least as effective as fin, I could get a HT, maintain what I've got and be back to a NW1 until I'm at least in my late 40s. That would be good enough for me. (I'm 32 now, NW2-3).

Minoxidil is used twice a day, i dont know how it's inconvienent to use a drug much more powerful than DUT/FIN without the side effects? takes you all of 5 minutes to use this stuff.

RU has side effects and is more complicated to use in the greymarket.

CB will become the new FIN and if it can be sold over the counter like Rogaine then it will be huge. and i've never seen a company not release great product because another product 'might' come out within a few years after, that's nonsense. Look how fast they are trying to get the acne version released and look how much competition there is in that market!

Sure a better cure might come out in 5-10 years, but its a ways away. Maintanence is key right now and is a possibility TODAY with stuff like CB.