stem cell news: iPS cells reverted to pristine state

[Arashi]

Researchers cracked a major hurlde in the iPS (cells reverted back to stem cells) area. Until now, the resulting iPS cells were still slightly genetically different from their Embryonic counterparts. The Europeans have not solved that and can now create pristine state stem cells from for example skin cells: http://www.sciencedaily.com/releases...0911125047.htm

[Arashi]

Who was in contact with dr Xu ? I think it was SdSurfin right ? I'd love to hear his comment on this breakthrough ! Maybe this facilitates the ipS -> DP cell differentation.

[2young2bald]

Arashi, I am quite new to this hair cloning business and don't seem to find much on google. As an experienced person could you tell me why it isn't possible yet, so what the problems are and how far we are with this? Actually I am wondering if there is anything to look forward to...

[Arashi]

Arashi, I am quite new to this hair cloning business and don't seem to find much on google. As an experienced person could you tell me why it isn't possible yet, so what the problems are and how far we are with this? Actually I am wondering if there is anything to look forward to...

Yeah we'd need a newbie FAQ. But in short: if we have DP cells we can grow hair, so the problem is getting those DP cells. There are 2 options to make DP cells:

1) Deduce stem cells to differentiate into DP cells or
2) Culture DP cells.

Nobody succeeded yet in doing that first, yet it seems a plausible route and Dr Xu also said this would be very possible. But since induced pluripotent stem cells weren't 100% identical to embryonic stem cells, that could have formed a big problem. It seems that's now out of the way but I don't have any idea how difficult it is to deduce inducede pluripotent stem cells, with this new method, to become DP cells and how well those would grow hair.

About culturing DP cells, the 2nd route: DP cells can now be cultured yet after culturing they lose gene expression so the cultured versions are not identical to their original counterparts anymore. The cultured DP cells can still induce hair follicles formation but since genetic information is lost, the resulting hair is not yet cosmetically viable (thin, white etc), so researchers are now trying to solve that.

[hellouser]

Yeah we'd need a newbie FAQ. But in short: if we have DP cells we can grow hair, so the problem is getting those DP cells. There are 2 options to make DP cells:

1) Deduce stem cells to differentiate into DP cells or
2) Culture DP cells.

Nobody succeeded yet in doing that first, yet it seems a plausible route and Dr Xu also said this would be very possible. But since induced pluripotent stem cells weren't 100% identical to embryonic stem cells, that could have formed a big problem. It seems that's now out of the way but I don't have any idea how difficult it is to deduce inducede pluripotent stem cells, with this new method, to become DP cells and how well those would grow hair.

About culturing DP cells, the 2nd route: DP cells can now be cultured yet after culturing they lose gene expression so the cultured versions are not identical to their original counterparts anymore. The cultured DP cells can still induce hair follicles formation but since genetic information is lost, the resulting hair is not yet cosmetically viable (thin, white etc), so researchers are now trying to solve that.

Didn't we think that follicles could only properly be 'cloned' if DP cells were cultured ALONG WITH epithelial cells?

[Arashi]

Didn't we think that follicles could only properly be 'cloned' if DP cells were cultured ALONG WITH epithelial cells?

There are all kinds of theories as what's causing the genetic loss and how to restore it but it seems plausible that it's indeed some kind of cell signaling that's missing in the current models.

[2young2bald]

Thank you for explaining. From what I read hair cloning is still far away. So, what do you think of hst and replicel. I heard replicel is doing phase 2 trails and are testing if more injections mean more regrowth.

[Arashi]

Thank you for explaining. From what I read hair cloning is still far away. So, what do you think of hst and replicel. I heard replicel is doing phase 2 trails and are testing if more injections mean more regrowth.

HST is a scam: http://www.hasci-exposed.com/
Replicel might be interesting but who knows. We've seen several 'interesting' companies come and go. So yeah at the moment, I'd say hair cloning is still 'far away'.

I'd say this is the most interesting development recently by far: https://www.baldtruthtalk.com/showthread.php?t=17394 if these guys can transform exisiting medicine like topical Fina or Dut so that there are no more side effects, then most of us can keep their hair for a LONG time to come ...

[2young2bald]

I know that HST is a scam, I actually meant HCS (histogen). But from what I read that means that there is nothing to look forward to , f***.

[Arashi]

I know that HST is a scam, I actually meant HCS (histogen). But from what I read that means that there is nothing to look forward to , f***.

Never give up hope ! And this is actually, in my opinion, the most promising news for a short term solution ever: https://www.baldtruthtalk.com/showthread.php?t=17394 and it came just out of nowhere, so who knows what else is in the pipeline. Stay strong !

[clarence]

Never give up hope ! And this is actually, in my opinion, the most promising news for a short term solution ever: https://www.baldtruthtalk.com/showthread.php?t=17394 and it came just out of nowhere, so who knows what else is in the pipeline. Stay strong !

The most promising news for a short term solution ever..... for those who currently cannot tolerate finasteride. The rest of us... will have to wait for other news.

[joachim]

Researchers cracked a major hurlde in the iPS (cells reverted back to stem cells) area. Until now, the resulting iPS cells were still slightly genetically different from their Embryonic counterparts. The Europeans have not solved that and can now create pristine state stem cells from for example skin cells: http://www.sciencedaily.com/releases...0911125047.htm

that's fantastic. the iPS research advancements are progressing very fast. every few months there are new groundbraking news around iPS cells. on the same day, there was this news too (creating brand new white blood cells from iPS cells):

http://www.sciencedaily.com/releases/2014/09/140911142716.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29

researchers worldwide are working on iPS cells now. the interest is huge, as it seems to be like the holy grail, or more like the fountain of youth. great times are coming.

but now that we know, that iPS cells are really fully capable of creating every cell type with no genetic difference, we should really establish a contact to dr. Xu to see what the next steps could be. we really need some researchers who are eager to create all hair related cells now. DP, DSC, Epithelial and whatelse. as soon as we have unlimited supply of all of those cells, then the cure is definitely near.
so, the idea of a crowdfunding for dr. Xu seems now absolutely reasonable to me. we shouldn't discard that route too fast again. considering the speedy advancements in iPS i wouldn't be surprised if someone like Dr. Xu could create those cells within a year. it's basically only a try and fail with different proteins, so a lot of different combinations have to be tried out. or maybe some other iPS researchers could be talked to as well. i mean, they already created some important cell types through iPS, so why not DP or DSC, too? it's only a matter of time and will. simply because not many researchers are concentrating on hair cells at the moment. dr. Xu is the only one we know so far.

[2young2bald]

Arashi could you give me a link where there is a lot of information about the causes of hair loss, studies etc if you have one?

[hal]

5 to 7 years before available

[Justinian]

that's fantastic. the iPS research advancements are progressing very fast. every few months there are new groundbraking news around iPS cells. on the same day, there was this news too (creating brand new white blood cells from iPS cells):

http://www.sciencedaily.com/releases/2014/09/140911142716.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29

but now that we know, that iPS cells are really fully capable of creating every cell type with no genetic difference, we should really establish a contact to dr. Xu to see what the next steps could be. we really need some researchers who are eager to create all hair related cells now. DP, DSC, Epithelial and whatelse. as soon as we have unlimited supply of all of those cells, then the cure is definitely near.
so, the idea of a crowdfunding for dr. Xu seems now absolutely reasonable to me. we shouldn't discard that route too fast again. considering the speedy advancements in iPS i wouldn't be surprised if someone like Dr. Xu could create those cells within a year. it's basically only a try and fail with different proteins, so a lot of different combinations have to be tried out. or maybe some other iPS researchers could be talked to as well. i mean, they already created some important cell types through iPS, so why not DP or DSC, too? it's only a matter of time and will. simply because not many researchers are concentrating on hair cells at the moment. dr. Xu is the only one we know so far.

Google tells me this Dr. Xu is affiliated with UPenn? It looks like he is already working on hair related research so would he need funding to continue? If we were to crowdfund, I know I would give a lot more if was something like this that I know is legit.