A traditional hair loss lotion from SouthEast Asia contains natural JAK inhibitor

[Recidive]

I want to share this finding. Although I don't think that the concentrations found in the herb itself or lotion (usually concentrations are too low) would produce cosmetically acceptable regrowth in most cases, it indicates that the lead of JAK inhibitors may be the key to pharmacological hair treatment.

this traditional herbal shampoo used in Southeast Asia seems to confirm the usefulness of JAK inhibitors for MPB hair loss.

There are several brands in Thailand, Philippines, India, e.g.:
Jinda Hair Lotion with Litsea glutinosa extract:

http://www.greenherbmarket.com/en/191--100-.html

Litsea glutinosa ("shampoo tree" in Thailand, or Indian Laurel) contains Brevilin A. Researchers have recently found that this compound is a significant JAK inhibitor:

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0063697

The roles of Brevilin A targeting on JAKs activity indicate that Brevilin A may not only be used as a STAT3 inhibitor but also a compound blocking other JAK-STAT hyperactivation...

Brevilin A showed high specificity on Janus Kinase activity and following STAT3 signaling without directly affecting some other signals...

[inbrugge]

Good find, bro. At this moment, I wonder if the users of the lotion have had any success. It's really tiring to keep taking punches in the dark with a new additive each time.

[Recidive]

Good find, bro. At this moment, I wonder if the users of the lotion have had any success. It's really tiring to keep taking punches in the dark with a new additive each time.

There are some amazing picture on the net, but probably photoshop or longer hair...http://www.ebay.com/itm/Jinda-Herb-H...-/271312421862

What I find interesting is how science may end up confirming some herbal remedies that have been used for millennia. Centipeda, an Australian plant used by the aboriginals for hair growth also contains Brevilin A!

http://www.hylunia.com/ingredient-dictionary/centipeda-cunninghamii-extract-2

Brevilin A is sold pure from chemical companies, but I guess there would be unknown safety problems, like with the synthetic JAK inhibitors.

[sdsurfin]

This should also be sent to christiano. Those photos look like they are the same person. I have great faith in traditional medicines, not to provide full cures, but to point the way towards what works and what doesn't. this was a great find.

[Recidive]

This should also be sent to christiano. Those photos look like they are the same person. I have great faith in traditional medicines, not to provide full cures, but to point the way towards what works and what doesn't. this was a great find.

The Chinese have patented Brevilin A in its use as a JAK inhibitor. However, I understand that natural products cannot be patented in the US and EU.

http://www.google.com/patents/CN102836151B?cl=en

[hellouser]

I read somewhere that janus kinase inhibitors promote CD200 progenitor cells (tofacitinib should do this). Downregulation of CD200 cells is present in AGA, I believe Cotsarelis talked about it at one point.

This Brevilin A could be interesting....

[Recidive]

I read somewhere that janus kinase inhibitors promote CD200 progenitor cells (tofacitinib should do this). Downregulation of CD200 cells is present in AGA, I believe Cotsarelis talked about it at one point.

This Brevilin A could be interesting....

These manufacturers sell pure Brevilin A if you are interested...

http://www.chemicalbook.com/ProdSupplierGNCB92519594_EN.htm

[blondetooth]

Spam

[noisette]

Spam

Why spam ? argues bro

[Shinobi]

Litsea glutinosa ("shampoo tree" in Thailand, or Indian Laurel) contains Brevilin A. Researchers have recently found that this compound is a significant JAK inhibitor:

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0063697

The roles of Brevilin A targeting on JAKs activity indicate that Brevilin A may not only be used as a STAT3 inhibitor but also a compound blocking other JAK-STAT hyperactivation...

Brevilin A showed high specificity on Janus Kinase activity and following STAT3 signaling without directly affecting some other signals...

... in cancer cells...

[hellouser]

I want to share this finding. Although I don't think that the concentrations found in the herb itself or lotion (usually concentrations are too low) would produce cosmetically acceptable regrowth in most cases, it indicates that the lead of JAK inhibitors may be the key to pharmacological hair treatment.

this traditional herbal shampoo used in Southeast Asia seems to confirm the usefulness of JAK inhibitors for MPB hair loss.

There are several brands in Thailand, Philippines, India, e.g.:
Jinda Hair Lotion with Litsea glutinosa extract:

http://www.greenherbmarket.com/en/191--100-.html

Litsea glutinosa ("shampoo tree" in Thailand, or Indian Laurel) contains Brevilin A. Researchers have recently found that this compound is a significant JAK inhibitor:

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0063697

The roles of Brevilin A targeting on JAKs activity indicate that Brevilin A may not only be used as a STAT3 inhibitor but also a compound blocking other JAK-STAT hyperactivation...

Brevilin A showed high specificity on Janus Kinase activity and following STAT3 signaling without directly affecting some other signals...

More interesting reading on Listea Glutinosa:

http://jpsr.pharmainfo.in/Documents/Volumes/Vol2Issue3/jpsr02031003.pdf

I think I'll try the shampoo.

[Kiwi]

More interesting reading on Listea Glutinosa:

http://jpsr.pharmainfo.in/Documents/Volumes/Vol2Issue3/jpsr02031003.pdf

I think I'll try the shampoo.

Which one are you going to try?

[Gjm127]

I just ordered the Jinda shampoo from Thailand on eBay. They're so confident that they would refund if I send back the bottle empty lol.

I'm just hoping it's Brevilin A content is high enough. The correlation with recent findings on this forum about Brevilin A/JAK inhibition AND the claims that this shampoo works with confidence is enough to warrant a try from my part. I need a change in shampoo anyway. Got 3 bottles for 35$.

Ill let you guys know how it goes but I'll just be starting Minox and Nizoral so I don't know how I'm gonna see if it's working or not...

[Gjm127]

http://www.ebay.com/itm/Jinda-Herb-Herbal-Hair-Renew-Reduce-Lotion-Tonic-hair-loss-bald-Natural-120-ml-/161410606840?pt=US_Hair_Care&hash=item2594d266f8

They also have a lotion. Pics don't really look fake, ugh I'm just giving myself useless hope. The only thing that interested me is the fact that hidden science about this JAK STAT inhibitor kind of correlates with their claims of regrowing hair.

[hellouser]

http://www.ebay.com/itm/Jinda-Herb-H...item2594d266f8

They also have a lotion. Pics don't really look fake, ugh I'm just giving myself useless hope. The only thing that interested me is the fact that hidden science about this JAK STAT inhibitor kind of correlates with their claims of regrowing hair.

You could always send an email to Dr. Brett King.....