low systemic absorption technology

[hgs1989]

Bald guy pic and hair follicles HERE.

Chuck

they even say a kinase inhibitor. can yale, columbia try that now for MPB since safety might not become an issue. someone should email them they would be interested because there AA treatment is dangerous and a topical formulation with this technology would seem logical to them.

[hellouser]

they even say a kinase inhibitor. can yale, columbia try that now for MPB since safety might not become an issue. someone should email them they would be interested because there AA treatment is dangerous and a topical formulation with this technology would seem logical to them.

I've reached out to Dr. Brett King on why he nor others bothered to try JAK inhibitors for MPB.

I never got a response. It's like these guys see us as a joke.

[hgs1989]

I've reached out to Dr. Brett King on why he nor others bothered to try JAK inhibitors for MPB.

I never got a response. It's like these guys see us as a joke.

well, christiano must feel a little more passionate about it since she knows what it means to lose hair.

[NeedHairASAP]

I dont want to call all of you idiots, but you dont want to email the company.

try and imagine how this plays out... you email them and then they say, oh, lets invest in a baldness cure. Lets hire new people or switch current employees over to work on this because baldguy888999 emailed us.

NO

e-mail some researchers to alert them of this vehicle. Email investors. email merk. email anybody but the company... they just want to license the tech, not make some major investment in applying it. THat isn't in their business model, i guarentee it

[hellouser]

well, christiano must feel a little more passionate about it since she knows what it means to lose hair.

Not passionate enough if it was only tried on AA and not 1 shit was given about AGA.

[sdsurfin]

Not passionate enough if it was only tried on AA and not 1 shit was given about AGA.

I'm sure they have thought about how it applies to mpb. In one of his interviews Brett king said that maybe they'd try it for mpb. If they haven't tried it, if means that they don't think it will work. I don't think it will either. Clinical trials cost millions.

I do agree with trying to call (not email) researchers and Merck and anyone involved with mpb and seeing if they can apply this lie systemic technology. Mercks propecia sales could go way up if they founds way to market it without sides. Or Cosmo. Or whoever is making avodart.

Someone should Definitely call Hasson and Wong and see if they can inquire about this. HT surgeons in general might get more business, and they generally care about mpb patients. So have a conversation with your ht docs. I for one am gonna try to get a pharmacy to make a fin topical with chitosan, cause if there's any chance of reduced sides, it's the best bet. CB is unproven and too expensive.

Lastly, there's a product made by shideido called adenogen, proven to be as effective as minox but different drug, those of who get dudes from minox might give it a shot...

[sdsurfin]

Ps forgive the typos. ****in phone

[hellouser]

I'm sure they have thought about how it applies to mpb.

You're giving them too much credit.

In one of his interviews Brett king said that maybe they'd try it for mpb.

Talk is cheap.

If they haven't tried it, if means that they don't think it will work.

That's pretty embarrassing considering the links between JAK inhibitors and AGA.

I don't think it will either.

Doesn't matter.

Clinical trials cost millions.

Wrong. This isn't a pharmaceutical. It's a single case study. You don't need millions of dollars to try it out on ONE guy with an already FDA approved drug.

Why are you giving these guys a pass? The 1% of hair loss sufferers just got a huge break, and the 99% which includes me and you are still f**ked and despite Tofacitinib's potential effects none of these doctors has done anything.

[sdsurfin]

You're giving them too much credit.



Talk is cheap.



That's pretty embarrassing considering the links between JAK inhibitors and AGA.



Doesn't matter.



Wrong. This isn't a pharmaceutical. It's a single case study. You don't need millions of dollars to try it out on ONE guy with an already FDA approved drug.

Why are you giving these guys a pass? The 1% of hair loss sufferers just got a huge break, and the 99% which includes me and you are still f**ked and despite Tofacitinib's potential effects none of these doctors has done anything.

ok man you win. They're all out to get you...

There's obviously no talking logic with you, but no one is against curing mpb. Christiano is one of the researchers who is testing these things. She works with people who have dedicated their whole careers to curing baldness. If they thought this was a good option they would get on it. They might be testing it to see if it has any effect, who knows, not you.....


There is no worldwide conspiracy to not cure baldness, it is an extremely complicated thing, much more so than Alopecia areata. I wish more teams and more money were being thrown at it too, but the fact is that as far as medical research goes, it hasn't gotten the short end of the stick at all. There are much more grave conditions that have received no attention at all. Really only things like cancer and aids have gotten more money thrown at them, and you can see that these complicated conditions are not so easy to reverse. Baldness in essence is really no less complicated than cancer. Perhaps more so, since cancer is a few cells going haywire, and baldness is a whole body system hellbent on shutting down. There's no point to getting obsessed or mad about the slowness, the most you can do is either go into hair research yourself or just get on with it. all these lotions and topicals etc are just a bandaid that slowly tears at your self esteem, because its a losing battle. someday they will grow whole new follicles and we can rejoice, but that day i fear is still far off.

[walrus]

Some people seem to think that demanding a cure will make it happen. Science doesn't work like that. Look at HIV and more recently ebola, there is plenty of will to produce a vaccine for both, but that does not mean it will ever happen or that it is even possible. Science progresses at its own rate, it has done before we got here, and will continue to do so long after we are gone. It doesn't 'owe' us anything. If a cure comes along for us to take advantage of, great, if not, complaining about it is non-productive unless you are somehow personally involved in the research process (maybe you are just not passionate enough?).

[hellouser]

Some people seem to think that demanding a cure will make it happen. Science doesn't work like that. Look at HIV and more recently ebola, there is plenty of will to produce a vaccine for both, but that does not mean it will ever happen or that it is even possible. Science progresses at its own rate, it has done before we got here, and will continue to do so long after we are gone. It doesn't 'owe' us anything. If a cure comes along for us to take advantage of, great, if not, complaining about it is non-productive unless you are somehow personally involved in the research process (maybe you are just not passionate enough?).

Who's tax dollars are spent on grants then?

[walrus]

Who's tax dollars are spent on grants then?

http://en.wikipedia.org/wiki/Scientific_method

Money facilitates research, but does not distort reality to your will.

[hellouser]

ok man you win. They're all out to get you...

There's obviously no talking logic with you, but no one is against curing mpb. Christiano is one of the researchers who is testing these things. She works with people who have dedicated their whole careers to curing baldness. If they thought this was a good option they would get on it. They might be testing it to see if it has any effect, who knows, not you.....


There is no worldwide conspiracy to not cure baldness, it is an extremely complicated thing, much more so than Alopecia areata. I wish more teams and more money were being thrown at it too, but the fact is that as far as medical research goes, it hasn't gotten the short end of the stick at all. There are much more grave conditions that have received no attention at all. Really only things like cancer and aids have gotten more money thrown at them, and you can see that these complicated conditions are not so easy to reverse. Baldness in essence is really no less complicated than cancer. Perhaps more so, since cancer is a few cells going haywire, and baldness is a whole body system hellbent on shutting down. There's no point to getting obsessed or mad about the slowness, the most you can do is either go into hair research yourself or just get on with it. all these lotions and topicals etc are just a bandaid that slowly tears at your self esteem, because its a losing battle. someday they will grow whole new follicles and we can rejoice, but that day i fear is still far off.

Wrong again. This isn't about your attempt to make me look like a conspiracy theorist. It is, as I have clearly stated (and you conveniently ignored) that AGA is largely ignored, doctors simply don't care enough. If they did, I wouldnt be able to count the number of doctors working on a solution with ONE HAND; Lauster, Jahoda, Christiano, Cotsarelis and Tsuji. What you fail to see is that out of 7 billion people on the planet only FIVE people are actually doing anything... and one of them are debatable anyway (Lauster's work is tied with EU's legislation on animal testing).

So yeah, hair loss whilst predominantly a men's health issue isn't given much respect or thought. If I had known in my teens what my 20s would look like with my hair and the socially crippling effects of it, I would have gone into bio engineering myself. Obviously that's too late now.

[sdsurfin]

Wrong again. This isn't about your attempt to make me look like a conspiracy theorist. It is, as I have clearly stated (and you conveniently ignored) that AGA is largely ignored, doctors simply don't care enough. If they did, I wouldnt be able to count the number of doctors working on a solution with ONE HAND; Lauster, Jahoda, Christiano, Cotsarelis and Tsuji. What you fail to see is that out of 7 billion people on the planet only FIVE people are actually doing anything... and one of them are debatable anyway (Lauster's work is tied with EU's legislation on animal testing).

So yeah, hair loss whilst predominantly a men's health issue isn't given much respect or thought. If I had known in my teens what my 20s would look like with my hair and the socially crippling effects of it, I would have gone into bio engineering myself. Obviously that's too late now.

There aren't very many teams working on any given disease. Those are also just the teams you know about. I never had heard of Dr. Xu or of Cosmo until very recently. There are plenty of efforts to understand hair by random researchers and schools, and like walrus said, science moves at its own pace. And These things do cost millions to work on and conduct broad clinical trials. We all want everything to move faster and have more money put into it, but its certainly not any researchers fault. If you want to wave your fist, wave it at the weapons manufacturers, congressmen, and big corporation guys who bleed the government of its money and put or tax dollars to shitty use. The researchers are the good guys.

And considering balding is mainly a cosmetic issue that most men experience, and most men don't have a huge problem dealing with, its not surprising that people don't care more about your plight. People like you that let it devastate their lives are few and far between. We all think it sucks but we don't let it define who we are. its called being a sensible adult, and I for one am glad that people don't fuss and worry about a mans appearance. Women for the most part, unless they are teenagers, don't really care what men look like, as long as they are confident and useful- and i think thats a liberating thing. You sound like you want to be a member of the band poison and be all pretty and that will make you happy and loved. Guess what, you're wrong. happiness comes from self acceptance and treating others kindly and making something of your life and having friends. I wish there was a cure too because I like hair, but If your lack of hair saps you of all your confidence, or anything relating to your looks for that matter, then you simply are not that strong or well developed internally, and should work on that and not be on these forums thinking that whining like a baby and calling people incompetent is going to have any effect whatsoever. Because it won't. Except to make people either angry at you or pity you, neither of which is positive. You might have a few teenage or twenty something idiots on here idolize you for voicing their insecurities so vehemently, but these are not adults with adult mindsets and you're not helping them in the long run.

[sdsurfin]

Also its really hard to take anyone seriously who talks in terms of balding being "socially crippling." I have four fully bald friends who lost it in their late teens and none of them were crippled socially. They are among the most social guys I know, and successful in their careers. None of them loved balding, but none of them let it cripple them. To suggest that hair is necessary for a good life is to beg for pity and to bring us all down to the level that you THINK society places us at. People will place you at whatever level you hold yourself to.