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I think dkk is better then oc , at least on paper ,
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I am not here to hurt your feelings or whatever you started me calling a idiot not the other way around. I'll always give a explanation of why i think or believe things as the way they are. And with follica if you think it through i just gave you a hint you'll understand why they still did not ever induce hair follicle neogenesis by wounding in HUMANS. Furthermore if you still disagree that's fine, thats your choice but don't start calling me a idiot.
I am not going to proof myself against you, i can assure you i'm not a desperate old man. I fought AGA for quite some time, to the point where i sometimes even went as a guineai pig lol and always trying to help others. Here are my pics hair pics the first one was already when i already used some RU and minox so it was a quite a bit worse (less density and thickening). I'm approaching NW1.5 now. My goal is NW1 though just because i got a bit greedy now lol;
Anyways back on topic i guess :P!Comment
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You see you are the one who is desperate, you are posting pictures of your hair on an online forum just to prove some anonymous stranger wrong. Very insecure of you. It's not all about hair, you must have other things too
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Well i certainly went full retard to discuss things with a complete idiot LOL. Now stop increasing those 800 useless posts of you mate. So other people can discuss freely on this subject.Comment
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To continue on this topic;
Btw about DKK1, and WNT pathway this is pretty interesting. Instead of inhibiting DKK1 these guys want to use a agent that directly activates the WNT pathway instead of inhibiting DKK1 and repressing WNT. That is what the original thing was; http://www.uphs.upenn.edu/news/News_...013/12/millar/. Manipulation of the Wnt/β-catenin pathway through DKK1, but as said they want to induce the WNT pathway directly here and a clinical trial has started up;
Really wonder how they got permission to do that in terms of cancer risks etc..? Pretty crazy lol. Perhaps someone can shoot them a e-mail.
Some more info;
Public title A Single-Center, Randomized, Double-Blind, Placebo Controlled Study of the Safety, Tolerability and Pharmacokinetics of Various Concentrations of Topical SM04554 Solution in Male Subjects with Androgenetic Alopecia.The study drug is a topical SM04554 solution. SM04554 is a small molecule that may activate the wnt pathway. The dosage amounts are: 0.05%; 0.15%; and 0.45%. Administration of the study drug will be once daily for 14 days at the study clinic; study drug is applied topically to the scalp. There are three cohorts of 10 participants. Cohort 1 will be administered the 0.05% solution, Cohort 2 will be administered the 0.15% solution and Cohort 3 will be administered the 0.45% solution. Participants will complete a series of tests prior to the start of the study. During the study the participants’ scalp will be assessed by the study doctor on a daily basis and prior to administration of the study drug. Hair growth assessments will also be completed by the study doctor and the participant 1 day following the completion of the treatment and 14 days following completion of the treatment.
Progenitor stem cells are the repair system of the body, replenishing various types of tissues as needed. One of the primary control pathways for these cells is the Wnt signaling pathway, which can be activated or inhibited to manage the extent and type of tissue they turn into. For example, progenitor stem cells will turn into bone or cartilage, based on whether the Wnt pathway in the vicinity of the bone or joints is activated or inhibited, respectively.
Using unique assays and screens, Samumed (formerly known as Wintherix & Epitherix) has identified a number of novel drug compounds to selectively activate or inhibit the Wnt pathway toward regenerative medicine and treatment of oncology and degenerative diseases. Our traditional small molecule drug development approach, combined with our unique ability to control the fate of latent human progenitor stem cells has enabled us to develop a series of breakthrough potential new treatments with high potency and excellent safety profiles.Comment
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I haven't read it but it's obvious that if they haven't succeeded yet they cannot succeed ever. You really hope they can do this?? Hahaha keep hoping you foolTo continue on this topic;
Btw about DKK1, and WNT pathway this is pretty interesting. Instead of inhibiting DKK1 these guys want to use a agent that directly activates the WNT pathway instead of inhibiting DKK1 and repressing WNT. That is what the original thing was; http://www.uphs.upenn.edu/news/News_...013/12/millar/. Manipulation of the Wnt/β-catenin pathway through DKK1, but as said they want to induce the WNT pathway directly here and a clinical trial has started up;
Really wonder how they got permission to do that in terms of cancer risks etc..? Pretty crazy lol. Perhaps someone can shoot them a e-mail.
Some more info;
http://www.samumed.com/Comment
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Really Thinning87 stop being an ass and making a complete fool of yourself. You practically started all this nonsense because you couldn't find a coherent way of disagreeing with someone else and just resorted to name-calling. What's ironic that this IS a forum about hairloss, so astonishingly people may actually post pictures of themselves and their hair. What's even more ironic is that you actually asked him to see a pictures of his hair, and after doing so you make up another insult. Seriously get your mood-swings checked and come back to the forum when you have something useful to say.Comment
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Dude stop using the cocaine mate or whatever you are on. I said that DKK1 topically doesn't work or internally won't work given the fact of the clinical trials done in cancer and that it has been used already (for hair regrowth). I also said Cotsarelis has never managed to induce de-novo neogenesis and i still stand by that. If you understand what he tries to do and you read the hint i gave you, you'll understand why. There is a distinct difference in regrowing hair or inducing de-novo neogenesis. Follica is trying to achieve the latter.
I have never seen any clinical trial or any medicine in clinical trials in inducing WNT pathway directly so I am highly surprised they are actually starting with it. Do I believe it will grow hair? Maybe, because it has never been done before. Will it induce de-novo with wounding? Nope. God you made my day so hard <3.Comment
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**** you. He made a comment about Cotsarelis's presentation admitting he hadn't even seen it. The comment he made implied they can't make any progress based on the fact that scientists always say everything is five years away, and what supposedly Cotsarelis intended or did not intend when speaking to Desmond. I pointed this out and got the smart ass reply. Again, the guy had t even seen the damn video. Like I said, go **** yourself.Comment
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I totally agree that Thinning's insults were undeserved and he shouldn't have insulted Swooping, but I disagree with your insinuation that he didn't say anything useful in his posts. In between posting insults he did post a counter-argument to Swooping's position and I think thinning's posit is much stronger than Swoopings. I think Thinning has a valid point when he states that Swooping has not proved that DKK1 does not aid in the fight against hair loss. I also do not think that's been proved. I think that Swooping is jumping the gun about that and I think that Thinning really way got the best of Thinning in that debate, although I also think that Thinning shouldn't be rude to Swooping. Swooping is a smart caring guy and even if he is wrong on the issue he and Thinning were debating about we are all wrong sometimes and Thinning should respect him.Comment
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Thinning really, you're right on the scientific issue but there is really no reason to get so mad and be so mean about it. You're hurting your own position because when you post so mean it makes others disagree with you on a personal leven and then they don't see the correctness of your point.Comment
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thinning shut the **** up
swooping knows WAY more about this shit than you do. stop being ****ing delusional this treatment has NO proof of being effective and I am tired of people like you hyping up god damn theories over and over.
this forum is falling the fck apart. if ANY of you guys are refraining from taking fin/dut/ru/minox/niz because you think these fcking articles somehow suggest we're less than 5 years away from something better than what we have then prepare to be very disappointed and to lose a lot of hair. i've been following this website since 2009 and guess how many effective treatments have come out? NONE. out of dozens and dozens of studies like this, not one treatment.Comment
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Swooping = wrong on facts/science
Thinning = right on facts/science
Thinning = wrong on being too mean.
We are all in this nightmare together. We should try to work together. We have enough trouble from people with full heads of hair hating on us so we should not be hating on each other.Comment
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Conpecia you're wrong.
Thinning's point is WAY stronger than Swooping's point. It has definitely not been proved that the DKK1 pathway does not matter. Thinning is right about that. But I do admit that Thinning should not disrespect Swooping. And I think that Thinning being rude to Swooping is causing other posters not to see the validitiy of Thinning's basic point about what has and hasn't been proved. Thinning is definitely right although he shouldn't be mean about it.Comment
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