Cotsarelis Presentation - PGD2 inhibition was reversed with blocker

[35YrsAfter]

So mpb is caused by Dht or Pgd2?
Pgd2 theory is overriding Dht doctrine?

My theory from my observations:
About a month ago, while I was present during the extraction of beard grafts, Dr. Cole commented that he rarely sees a beard hair in telogen. When you press on the chin where beard growth is generally thick and healthy, notice how there is a "spongy" thick adipose layer. Valerie Horsley's Yale hair growth study indicates the adipose layer plays a role in signaling the release of blood platelet growth factors to nourish hair follicles. Balding scalp has a reduced layer of fat. The reduction in growth factors sends the hair into an extended (resting) telogen phase. Extended telogen may trigger an over production of prostaglandin D2. Prostaglandin D2 can induce apoptosis in other parts of the body. Apoptosis and Prostaglandin D2 have been shown to play a role in normal hair cycles on a male scalp not affected by Androgenic Alopecia. Constantly hammering healthy hair follicles with PGD2 can't be good. When mice were injected with PGD2, they lost hair. George Cotsarelis believes it's the imbalance that's responsible for MPB. Perhaps like a leafless deciduous tree stuck in winter mode because it lacks the pro-growth factors normally associated with Spring and Summer. Of course without leaves, the tree will wither and die.

35YrsAfter also posts as CITNews and works at Dr. Cole's office - Cole Hair Transplant, 1045 Powers Place, Alpharetta, Georgia 30009 - Phone 678-566-1011
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

[hellouser]

But you still could get regrowth with RU and minox, combating DHT only.

Its not good enough and doesnt work for everyone anyway. Plus,its a bandaid solution.

[Hairismylife]

MPB suffers at the effects of DHT and PGD2 overexpression. Reversing the two does NOT reverse hair loss. There's more thats going on with MPB anyway;

Upregulation of DKK1 and arachidonic acid. Then downregulation of PGE2, CD200 and CD34 progenitor cells.

You'd need to combat all that. Latanoprost has been known to work on hair by working on the PGF2 and PGE2 receptor and the stuff had worked quite well on diffuse thinners.

But you still could get regrowth with RU and minox, combating DHT only.

[It's2014ComeOnAlready]

We were all of the impression they were very close to releasing something until the World Hair Conference, and we realised they wree way off, Cots told desmond that he needs 20 Million and more years of work before releasing anything

Oh, please. That was nothing but misinformation. The actual quote goes something like this: "$2 million will bring a treatment that's more effective that minoxidil and propecia, $20 million would bring the type of funding needed to give a bald person a full head of hair, but will take more years to achieve."

They don't have $2 million for a drug that's more effective that minoxidil and propecia? I understand puretech ventures received $55 million for a number of treatments in their pipeline, and follica wasn't mentioned. So you mean to tell me they have a drug that could solve hair loss potentially for both men and women, with no sexual side effects, that could bring in billions every year, and they're too cheap to shell out $2 million for it? Then they are the biggest morons history has every known.

[Hairismylife]

I understand that that's what they've been saying. I find it very hard to believe that's the case, because this discovery is a potential one-stop shop to prevent hair loss in men and women. NO other drug will be able to compete, if what I understand about PGD2 inhibition is true. BILLIONS of dollars per year, BILLIONS. I guess no one in America wants to make BILLIONS.

Cots patent it already?

[It's2014ComeOnAlready]

They aren't in any clinical trials right now, so I don't see how they could be close to releasing something.

I understand that that's what they've been saying. I find it very hard to believe that's the case, because this discovery is a potential one-stop shop to prevent hair loss in men and women. NO other drug will be able to compete, if what I understand about PGD2 inhibition is true. BILLIONS of dollars per year, BILLIONS. I guess no one in America wants to make BILLIONS.

[joely]

Because I've read a lot of the literature that's available on his an Garza's work. Cots and his team know everything they will need to know in order to successfully bring a treatment to market. That's the impression I got, and just because Follica is tight-lipped doesn't mean things aren't happening. Their discovery is worth billions, and there's no way they're not very close to releasing something given all the information about his work that we have.

We were all of the impression they were very close to releasing something until the World Hair Conference, and we realised they wree way off, Cots told desmond that he needs 20 Million and more years of work before releasing anything

[FearTheLoss]

Because I've read a lot of the literature that's available on his an Garza's work. Cots and his team know everything they will need to know in order to successfully bring a treatment to market. That's the impression I got, and just because Follica is tight-lipped doesn't mean things aren't happening. Their discovery is worth billions, and there's no way they're not very close to releasing something given all the information about his work that we have.

They aren't in any clinical trials right now, so I don't see how they could be close to releasing something.

[It's2014ComeOnAlready]

How do you know?

Because I've read a lot of the literature that's available on his an Garza's work. Cots and his team know everything they will need to know in order to successfully bring a treatment to market. That's the impression I got, and just because Follica is tight-lipped doesn't mean things aren't happening. Their discovery is worth billions, and there's no way they're not very close to releasing something given all the information about his work that we have.

[hellouser]

So mpb is caused by Dht or Pgd2?
Pgd2 theory is overriding Dht doctrine?

MPB suffers at the effects of DHT and PGD2 overexpression. Reversing the two does NOT reverse hair loss. There's more thats going on with MPB anyway;

Upregulation of DKK1 and arachidonic acid. Then downregulation of PGE2, CD200 and CD34 progenitor cells.

You'd need to combat all that. Latanoprost has been known to work on hair by working on the PGF2 and PGE2 receptor and the stuff had worked quite well on diffuse thinners.

[It's2014ComeOnAlready]

So mpb is caused by Dht or Pgd2?
Pgd2 theory is overriding Dht doctrine?

From what I understand, both an excess of pgd2 on the scalp as well as DHT are testosterone dependent. If Cotsarelis is confident that blocking PGD2 will let you be able to keep your hair, then I really don't care which one it is. I'm just tired of using fin.

[Hairismylife]

So mpb is caused by Dht or Pgd2?
Pgd2 theory is overriding Dht doctrine?

[35YrsAfter]

Oh, he knows.

I wonder if ATOPIX knows a very effective treatment for MPB could be worth billions.


Chuck

[Jonathan]

At around 22:50 in the video the doctor says that at least 7 companies developed PGD2 inhibitors (against asthma) already. I don't fully understand what he says, since my English and general knowledge is not good enough but if there are safe asthma drugs out there, why are we not trying and rubbing them into our heads right now?! It would be nice if any of the more knowledgeable members could look into this and share their thoughts.

https://www.youtube.com/watch?v=TN5H01HGaVI

We are close now, I can feel it! Soon one of all the researches that are going on parallel will come with a huge breakthrough.

[HairlossAt15]

Oh, he knows.

How do you know?