Possible Treatments

[35YrsAfter]

A 2012 MPB study determined the most common cause of hair loss in men—results from elevated amounts of a lipid called prostaglandin D2 (PGD2). The researchers also identified a receptor molecule—a protein called GPR44—that binds with PGD2 on the surface of cells in the hair follicle. Such binding is needed to produce the condition of limited hair growth that is symptomatic of AGA.

PGD2 is among other things a potent inhibitor of platelet aggregation.

PRP (platelet rich plasma) treatment on the other hand, (to varying degrees) increases the hair shaft diameter of miniaturized hair.

Consider what Rogaine does. Although minimally effective, it dilates blood vessels and increases blood flow. Other than that, researchers don't know why it is slightly effective in improving hair growth. A negative related to healthy hair growth cited in a study written by Dr. Sharon Keene is cigarette smoking. As you know smoking constricts blood vessels.

Perhaps hair miniaturizes in MPB because the concentration of Prostaglandin D2 (in green) starves the follicle of necessary blood platelet growth factors.

35YrsAfter also posts as CITNews and works at Dr. Cole's office
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email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

[hellouser]

Link source?

[35YrsAfter]

Link source?

niams.nih.gov

Chuck

[baldozer]

Man is preparing to inhabit Mars and yet we are unsure about what really causes baldness as evident from this statement, "Perhaps hair miniaturizes in MPB because the concentration of Prostaglandin D2 (in green) starves the follicle of necessary blood platelet growth factors." We need to get smarter people in medical research.

[HairBane]

This sounds like it would fit with current theories. So where does DHT come into it? Does DHT cause an increase in PGD2, or just make the receptors more sensitive to it?

[burtandernie]

Sounds like a good hypothesis to me now someone needs to test it and see if its true. Time is of the essence because unfortunately we only live so long

[DesperateOne]

Sounds like a good hypothesis to me now someone needs to test it and see if its true. Time is of the essence because unfortunately we only live so long

So how do you suggest we proceed, with a pgd2 inhibitor?
We have taken that train already with no luck in the past.

I will share something here that may be useful or may not, but it seems to relate a bit. At the start of the year I bough three months of neogenic and I noticed a dramatic increase in hair gain, I am not %100 sure it was because it but that was the only thing I had added new. Anyways, I bring this up because someone in another forum was saying similar things about the neogenic product and the pgd2, I think it was squeegee.

I ended up not using it anymore because I thought it wasn't working and it was hella expensive, but looking back I don't see what else could have given me this regrowth. One very important thing for me to say is that I don't have MPB, mine is more like DUPA, so I would be interested if others with DUPA tried.

[deuce]

Am I missing something? Did this not make it big in 2012 then die down quickly? Cotsarelis was claiming something would be on the market in two years with regards to this. lol

[hellouser]

Am I missing something? Did this not make it big in 2012 then die down quickly? Cotsarelis was claiming something would be on the market in two years with regards to this. lol

Cotsarelis is an attentionwhore. I wouldn't be surprised if he made another '2-5' claim at the Hair Congress next month. This guy has been all talk and ZERO results for the past 10+ years.

[deuce]

Cotsarelis is an attentionwhore. I wouldn't be surprised if he made another '2-5' claim at the Hair Congress next month. This guy has been all talk and ZERO results for the past 10+ years.

Definitely man. The dude sits there with a full head of hair getting us baldies hopes up. 2012 it was the pdg2. Last year it was wounding and Fgf9. I will believe that guy when he has products and results to go with them.

[Hair Bear]

As much as people rip on him, he at least remains dedicated to his research in the field and does not peddle any products and make completely false claims which affects our pockets.
There are shady operators out there that take this man's research and market it without any idea what they are doing.

I am not saying this guy is brilliant and also agree that the research aspect can be frustrating but we gotta hang in there.
Truth is you guys are probably much better of hair wise (and most likely financially) and socially than I am so there is still chance for you, also geographically you are probably well within range of decent active research and when and if the FDA finally approves something you will be the first to sample it out where as some other people may have to wait upon successful trial by their respective countries governing body of medical authority such as the TGA for example which will most likely aim to run their own trials worse yet if it is a service rendered as their will be additional time needed for doctors to understand and master the technique.

Simply put Cotsarelis gives us hope even though nothing seems to eventuate from it and ultimately disappoints us, other shady pharma companies give us false claims, false hope, disappointment whilst also taking our hard earned money.

Anyway back on topic, this pgd2 theory has been around for a long time and as everyone knows pgd2 can be obtained on the black market however it has not yielded any encouraging results thus far that would warrant it being the solution at this stage.

[walrus]

Cotsarelis is an attentionwhore. I wouldn't be surprised if he made another '2-5' claim at the Hair Congress next month. This guy has been all talk and ZERO results for the past 10+ years.

There are 'results' in his publications. Go read them.

Commercialisation of a product is not usually the responsibility of a researcher.

[baldozer]

Cotsarelis is an attentionwhore. I wouldn't be surprised if he made another '2-5' claim at the Hair Congress next month. This guy has been all talk and ZERO results for the past 10+ years.

Most of the medical research is like that. Too much talk but no results. Haven't you seen the cancer research funded by charity companies, promising to deliver a cure since the last 4 or 5 decades, with ZERO output! A cure is always around the corner, but never happens, just like the mirage on the road in a hot day!

[greatjob!]

Most of the medical research is like that. Too much talk but no results. Haven't you seen the cancer research funded by charity companies, promising to deliver a cure since the last 4 or 5 decades, with ZERO output! A cure is always around the corner, but never happens, just like the mirage on the road in a hot day!

Yeah because curing cancer is so simple, thinking before speaking is recommended.

[moore]

Definitely man. The dude sits there with a full head of hair getting us baldies hopes up. 2012 it was the pdg2. Last year it was wounding and Fgf9. I will believe that guy when he has products and results to go with them.

Actually Cotsarelis apparently admitted to suffer from a vertex loss:

http://whyy.org/cms/radiotimes/2012/10/08/hair-and-who-we-are/

at minute -29:47

On a side notes:
-The other interviewee, Albert Mannes, is so in denial. I already wrote that, but everytime I listen to this interview I wish I was there to yell in his ears that he is being part of the problem, and not of the solution. Such a sad man.

-Cotsarelis himself is expressing quite some typical cognitive dissonance ideas, saying that:
- he is quite tall so he does not shave his head just because of this, or
- a woman with fewer hair would not make any difference to someone who sees them for the first time (what about someone who has been seeing them for a lifetime then???)
And okay, maybe he does not bother as much as most of us about his hairloss.


PS guys, I think there is plenty of evidence there as well:

http://en.wikipedia.org/wiki/Hair_cloning

And reading this very page, I can not help wondering whether the big pharma is actually hampering hair cloning research.