8th World Congress For Hair Research - Korea (2014)

[nameless]

2 important points:

1. This thread is not supposed to be an "attack-Nigam-thread" so please stop the attacks against Nigam. Everyone knows that there are some posters who think Nigam is OK so when the Nigam-haters do attacks against Nigam they're starting arguments about whether or not Nigam is positive or a negative. It would be OK if this were a Nigam thread but it isn't. The Nigam haters initiate arguments about Nigam in threads that are not even about Nigam and they should stop. I'm happy to discuss Nigam in a Nigam thread but please stop ruining every thread with the Nigam attacks.

2. It looks to me like there may not be any new breakthrough at the 2014 Hair Loss Congress. It looks to me like all they have accomplished so far is to replicate Jahoda's study from last year. I don't see where any of the 2014 Hair Loss Congress abstracts involve increasing trichogenicity in cultured DP cells beyond what Jahoda already presented last year. It looks like the 2014 Hair Loss Congress abstracts refer to "partial" preservation of trichogenicity just like Jahoda's 2013 study but no improvement beyond that.

[nameless]

Hey Hell Sorry I was so excited I forgot to post the link. Here's the link to titles of all abstracts:

http://www.hair2014.org/contents.asp?midx=8&sidx=75&openpage=8&menuov=Accepted%20Abstract

Cheers

This one in particular looks the most promising for the immediate future:

3D MICRO HAIR FOLLICLE CULTURE IN A DYNAMIC CHIP BIOREACTOR

I don't know how far advanced this is, but if they can grow follicles (to perfect completion) in a bioreactor outside the body then that should mean they can create an unlimited donor supply because if they can create one follicle then why not 100,000?

The other subjects appear to be simply re-creating results that others have already accomplished or slight advances, but creating bioreactor follicles could be huge if they are producing perfect follicles. It would probably have to go through clinical trials but that doesn't seem fair because really all they're doing is growing your own hair outside your body and then sticking it back in you.

[UK_]

VERY EXCITING NEWS

Hey guys, the abstract titles for this year's Hair congress just got announced and some of these talks look absolutely ground breaking. Here's the TOP SIX presentations that I picked out which show 6 different research teams cracking the DP culturing problems, while another team has found what makes the DP cells in the MPB zone so different to the permanent zone. It's also interesting to note that these 6 teams are NOT part of the Chinese or Taiwanese teams we already knew about.

It seems that this beast is about to be cracked I will post more information once more information is published. Science is finally giving us the answers we were waiting for

Here are the titles:

1) P032: GENOME-WIDE EXPRESSION PROFILE ANLYSIS OF 3D CULTURED DERMAL PAPILLA CELLS FROM ANDROGENIC ALOPECIA PATIENTS
Weixin Fan

2) P081 (WS3): DERMAL-EPIDERMAL INTERACTIONS IN 3D CULTURE RESTORE MARKERS OF DERMAL PAPILLA INDUCTIVITY
Aaron Gardner

3) P082 (WS3): 3D MICRO HAIR FOLLICLE CULTURE IN A DYNAMIC CHIP BIOREACTOR
Beren Atac

4) P202 (SY10): REPROGRAMMING REGULAR SKIN FIBROBLASTS INTO HAIR INDUCING DERMAL PAPILLA CELLS
Carlos Clavel

5) P221 (FC6): ENHANCING EXPRESSION OF HAIR INDUCTION MARKERS IN HUMAN DERMAL PAPILLA CELLS
ARP Sari

6) P228 (SY3): OPTIMIZED PREPARATION OF DERMAL PAPILLA CELL (DP) AND DERMAL SHEATH CELL (DS) CONSTRUCT FOR HAIR REGENERATION
Koji Kanayama

__________________________________________________ _____________

On a side note, the third title points out to growing hair germs (microtissues) in a bioreactor to maturations prior to transplantation. Sounds very cool!

What a great year so far A big thumbs up to all these researchers working towards a final cure.

No Histogen No Follica No Replicel.

Nothing.

Just a dead concert of scientists that are still all 30 - 40 years away from even clinical trial.

Its over.

[ytterligare]

You're very optimistic, UK_. I think it's at least 200 years more to wait.

[Arashi]

I don't see where any of the 2014 Hair Loss Congress abstracts involve increasing trichogenicity in cultured DP cells beyond what Jahoda already presented last year. It looks like the 2014 Hair Loss Congress abstracts refer to "partial" preservation of trichogenicity just like Jahoda's 2013 study but no improvement beyond that.

Yeah man. You're right. All those presentations about increasing trichogenicity are 'LOOK WE CAN DO IT TOO !!' speaches. Even the one from Aaron Gardner, who is a member of Jahoda's group also just wants to say "LOOK WHAT MY HOMIE JAHODA DID A YEAR AGO I CAN DO TOO NOW !!!"

Now please go to HS again JarJarbinx and leave topics you're totally clueless about to the others. Clearly these are all speeches about improving Jahoda's breakthrough method from last year. How far they got and where they are now, we will only know if we manage to send somebody to WCHR2014: http://www.baldtruthtalk.com/showthread.php?t=15734

[The Alchemist]

Yeah man. You're right. All those presentations about increasing trichogenicity are 'LOOK WE CAN DO IT TOO !!' speaches. Even the one from Aaron Gardner, who is a member of Jahoda's group also just wants to say "LOOK WHAT MY HOMIE JAHODA DID A YEAR AGO I CAN DO TOO NOW !!!"

Now please go to HS again JarJarbinx and leave topics you're totally clueless about to the others. Clearly these are all speeches about improving Jahoda's breakthrough method from last year. How far they got and where they are now, we will only know if we manage to send somebody to WCHR2014: http://www.baldtruthtalk.com/showthread.php?t=15734

You might have some success emailing the scientists, tell them you're interested in what they have to say but can't make the congress. Ask them for a copy of the abstract they're submitting. I'd be willing to bet some would respond in kind. It's not like the information is protected property.

[youngin]

This DP culturing and micro-organ creation is only really a cure if the secret to non bald scalp is non balding DP cells. My guess is that the entire scalp environment is different, as well as the signals between the body as a whole and the balding scalp. Transplants bypass this issue by moving the implanted follicle in a substantial chunk of donor skin. I would love to know how exactly DHT begins and mediates the process, and if our androgen receptors exist only on the DP cells or on all different kinds of cells in the balding scalps. If the androgen receptors are only on the DP cells, then maybe this is indeed a cure that will work soon. The frustrating thing about this forum is that there doesn't seem to be anyone on here that actually knows much about this kind of science beyond the basics.

Then again, if the newly formed follicles are not DHT resistant, they may still function for a number of years, which means a re-up on your treatment. I'm incredibly curious to know how the taiwanese study will go, someone on this forum that is in that part of the country needs to work on a connection there, it's gonna suck to have to wait til 2016 or whenever that study is over.

There are other AR's in the follicle structure, for instance the sebaceous glands. The ones of concern are most likely the DP's though. The whole cells are mutated so they must be replaced or signaled to change. There are studies about this.

[nameless]

Yeah man. You're right. All those presentations about increasing trichogenicity are 'LOOK WE CAN DO IT TOO !!' speaches. Even the one from Aaron Gardner, who is a member of Jahoda's group also just wants to say "LOOK WHAT MY HOMIE JAHODA DID A YEAR AGO I CAN DO TOO NOW !!!"

Now please go to HS again JarJarbinx and leave topics you're totally clueless about to the others. Clearly these are all speeches about improving Jahoda's breakthrough method from last year. How far they got and where they are now, we will only know if we manage to send somebody to WCHR2014: http://www.baldtruthtalk.com/showthread.php?t=15734

I hope you're right but there is not one word released so far that states that they've improved on Jahoda's trichogenicity results.

[nameless]

Yeah man. You're right. All those presentations about increasing trichogenicity are 'LOOK WE CAN DO IT TOO !!' speaches. Even the one from Aaron Gardner, who is a member of Jahoda's group also just wants to say "LOOK WHAT MY HOMIE JAHODA DID A YEAR AGO I CAN DO TOO NOW !!!"

Now please go to HS again JarJarbinx and leave topics you're totally clueless about to the others. Clearly these are all speeches about improving Jahoda's breakthrough method from last year. How far they got and where they are now, we will only know if we manage to send somebody to WCHR2014: http://www.baldtruthtalk.com/showthread.php?t=15734

You say that the presenters at the 2014 Hair Loss Congress are reporting significant advances over what Jahoda presented last year. Will you please prove your assertions? Please provide a link that proves that even one of the 2014 Hair Loss Congress presenters will provide significant progress with retatining the trichogenicity of DP cells over what Jahoda described last year. If you don't provide this proof then what you are doing is called speculation.

[sdsurfin]

well,,,

You say that the presenters at the 2014 Hair Loss Congress are reporting significant advances over what Jahoda presented last year. Will you please prove your assertions? Please provide a link that proves that even one of the 2014 Hair Loss Congress presenters will provide significant progress with retatining the trichogenicity of DP cells over what Jahoda described last year. If you don't provide this proof then what you are doing is called speculation.

I think it's pretty obvious that teams have managed to improve at least a little (especially since aaron gardner is on jahoda's team), but to what extent we have no idea, and I would guess (in an educated way based on the input of Dr. Xu, who I've been talking to) that we are ver very far from a pre-clinical cure.

[Arashi]

You say that the presenters at the 2014 Hair Loss Congress are reporting significant advances over what Jahoda presented last year. Will you please prove your assertions? Please provide a link that proves that even one of the 2014 Hair Loss Congress presenters will provide significant progress with retatining the trichogenicity of DP cells over what Jahoda described last year. If you don't provide this proof then what you are doing is called speculation.

Sigh. Really. If you read the topic titles Desmond posted in the first post of this thread, it's really not that hard to see that ALL these topics are about continuing where Jahoda left off. If you can't understand that, really, then just stop posting here. Nobody knows how far they came and how succesful they were, that is why we need to get someone there who can report to us, cause if nobody does that, then WCHR 2014 will go by and we will be totally in the dark ...

[nameless]

Sigh. Really. If you read the topic titles Desmond posted in the first post of this thread, it's really not that hard to see that ALL these topics are about continuing where Jahoda left off. If you can't understand that, really, then just stop posting here. Nobody knows how far they came and how succesful they were, that is why we need to get someone there who can report to us, cause if nobody does that, then WCHR 2014 will go by and we will be totally in the dark ...

1. The topics do not explicity state that they continue where Jahoda left off.
It may be true but the topics do not say that.

2. Don't tell me where to post.

3. I will not be in the dark because you-know-who will inform me what took place at the WCHR. So I don't need anyone else to tell me what happens there.

[The Alchemist]

This is a recent abstract from Carlos Clavel, who's presenting at WCHR. His material at WCHR will probably be the same, or closely related.

Dr Carlos Clavel Mount Sinai School of Medicine, New York, USA

Title: “Transcriptional Control of the
Hair‐Inducing Fate of Dermal Papilla Cells”

Abstract:
How dermal papilla (DP) niche cells regulate hair follicle (HF) progenitors to control hair growth remains unclear. Using novel genetic tools to study DP cells in the HF stem cell (SC) niche, we have recently shown how the gene Sox2 is a key regulator of hair growth in the DP compartment, controlling the BMP‐mediated mesenchymal‐epithelial crosstalk between DP niche cells and SC progeny. Now, we have identified a color switch in the pelage of DP‐specific Sox2 knock down mice and observed abnormal levels of BMP signaling in the melanocyte compartment of the HF. This phenotype suggests that Sox2 is also a master regulator of the melanocyte SC niche. Unfortunately the capacity of DP cells to induce hair
growth by instructing HF SC cells is lost during cell culture expansion, so that no cell‐based regenerative therapies are yet available to restore follicles in hair loss patients or to generate new follicles in patients with debilitating skin disorders. To generate sufficient cell quantities for hair regenerative therapies, we sought to reprogram regular fibroblasts into DP cells. Overexpression of DP signature transcription factors (TFs) in naive fibroblasts upregulates several DP signature genes, and TF‐overexpressing fibroblast lines isolated from double‐transgenic reporter mice activates DP reporter activity. Our preliminary data suggest that the right combination of DP TFs can reprogram DP niche fate in regular fibroblasts that can potentially be utilized in future hair restoration efforts.


From the looks of his photo, he's a motivated hairloss researcher

[nameless]

This is a recent abstract from Carlos Clavel, who's presenting at WCHR. His material at WCHR will probably be the same, or closely related.

Dr Carlos Clavel Mount Sinai School of Medicine, New York, USA

Title: “Transcriptional Control of the
Hair‐Inducing Fate of Dermal Papilla Cells”

Abstract:
How dermal papilla (DP) niche cells regulate hair follicle (HF) progenitors to control hair growth remains unclear. Using novel genetic tools to study DP cells in the HF stem cell (SC) niche, we have recently shown how the gene Sox2 is a key regulator of hair growth in the DP compartment, controlling the BMP‐mediated mesenchymal‐epithelial crosstalk between DP niche cells and SC progeny. Now, we have identified a color switch in the pelage of DP‐specific Sox2 knock down mice and observed abnormal levels of BMP signaling in the melanocyte compartment of the HF. This phenotype suggests that Sox2 is also a master regulator of the melanocyte SC niche. Unfortunately the capacity of DP cells to induce hair
growth by instructing HF SC cells is lost during cell culture expansion, so that no cell‐based regenerative therapies are yet available to restore follicles in hair loss patients or to generate new follicles in patients with debilitating skin disorders. To generate sufficient cell quantities for hair regenerative therapies, we sought to reprogram regular fibroblasts into DP cells. Overexpression of DP signature transcription factors (TFs) in naive fibroblasts upregulates several DP signature genes, and TF‐overexpressing fibroblast lines isolated from double‐transgenic reporter mice activates DP reporter activity. Our preliminary data suggest that the right combination of DP TFs can reprogram DP niche fate in regular fibroblasts that can potentially be utilized in future hair restoration efforts.


From the looks of his photo, he's a motivated hairloss researcher

This paper does not indicate a treatment that could be put into the form of a practical treatment for clinical trials or even pre-clinical testing. What this sounds like is merely an avenue for researchers to begin exploring so they can one day create a treatment to run through pre-clinical and clinical trials. It sounds like basic research - where a researcher is looking for a place to start.

[534623]

From the looks of his photo, he's a motivated hairloss researcher

Practically all individuals on this strange planet are motivated just due to the looks of something.

Concerning Carlos Clavel's title “Transcriptional Control of the Hair‐Inducing Fate of Dermal Papilla Cells” makes him just ridiculously among real experts; because WHO ever said and provided HARD FACTS that DP cells in general are responsible for the "fate" of hair growth induction in general?