Human lung created in the lab

[Molten]

What's missing in the human scalp for hair follicles to grow? Whats so different about scalp where MPB exists compared to the sides and back of the head where scalp is capable of growing hair NORMALLY?

For starters, the hair on your back is your native hair. They have the exact same spatial regulation and structure as the hair follicles that are in the front. Engraftment essentially ruins all of that and in the end makes the engineered hair follicles vastly inferior to your natural ones. There is no method I know of that addresses this fundamental issue and all of them seemed to have ignored it. This along with a few other reasons is why they are failing and will continue to fail.

Of course, I'm open to the possibility that I'm wrong and will gladly come here and admit I am wrong if any one of these teams are successful. But, that possibility is increasingly remote.

[hellouser]

For starters, the hair on your back is your native hair. They have the exact same spatial regulation and structure as the hair follicles that are in the front. Engraftment essentially ruins all of that and in the end makes the engineered hair follicles vastly inferior to your natural ones. There is no method I know of that addresses this fundamental issue and all of them seemed to have ignored it. This along with a few other reasons is why they are failing and will continue to fail.

Of course, I'm open to the possibility that I'm wrong and will gladly come here and admit I am wrong if any one of these teams are successful. But, that possibility is increasingly remote.

What is 'engraftment' ??

[Molten]

You're dead wrong again. I advise you to read up here: http://www.sangamo.com With their platform they can flip any gene on/off in any organism, including humans.

I'll definitely read that and comment further, thanks for posting that.

However, even if they can do that at this time, there is no way to know if the genes they are shutting off won't affect something else, which could lead to severe injury at best and death at worst. No one has any idea what genes are involved to cause MPB, and even if we did, we have no way to know if these same genes are also indirectly responsible for keeping your liver running.

[Molten]

What is 'engraftment' ??

Simply put, it's the process of transplanting the hair stem cells to the human skull.

[hellouser]

Simply put, it's the process of transplanting the hair stem cells to the human skull.

Ah, but you say engraftment ruins it (spacing etc). Why would spacing matter considering a hair transplant also spaces out grafts yet the hair lives as normal.

[Arashi]

I'll definitely read that and comment further, thanks for posting that.

However, even if they can do that at this time, there is no way to know if the genes they are shutting off won't affect something else, which could lead to severe injury at best and death at worst. No one has any idea what genes are involved to cause MPB, and even if we did, we have no way to know if these same genes are also indirectly responsible for keeping your liver running.

To this I agree. Research would be necessary to find out which genes to flip. But again, this is not the road to go down. Nobody wants to flip genes on/off to solve the hairloss puzzle, even more since we've made so much progress at bio generating hair follicles that there's really no necessity. It would take years. But nowhere the 300 years you quoted before

[Molten]

Ah, but you say engraftment ruins it (spacing etc). Why would spacing matter considering a hair transplant also spaces out grafts yet the hair lives as normal.

Comparing this method to a hair transplant is like comparing apples and oranges. For starters, a hair transplant does not at all change the cell structure of the hair follicles.

[hellouser]

Comparing this method to a hair transplant is like comparing apples and oranges. For starters, a hair transplant does not at all change the cell structure of the hair follicles.

Yeah but suppose a fully functioning follicle is developed in the scalp... you don't think it will grow hair?

[Molten]

Yeah but suppose a fully functioning follicle is developed in the scalp... you don't think it will grow hair?

That's what the debate is about. I don't think it can be done for reasons I stated above for other reasons. I would have more faith in these teams if they actually bothered to even address these issues, but they don't.

Of course, I really do hope I'm proven wrong but I won't hold my breath.

[Arashi]

That's what the debate is about. I don't think it can be done for reasons I stated above for other reasons. I would have more faith in these teams if they actually bothered to even address these issues, but they don't.

I think you've just not read up to the subject. Tsuji lab biogenerated human hair follicles that produced human hair with all cosmetically correct charateristics, albeit on a mouse skin, two years ago.

DNA analysis revealed that the hair was 100% human.

Last year, Jahoda repeated that experiment, but not with existing cells, but this time even with cultured cells (!!!), again human hair but this time even on human skin, albeit gene expression was not high enough yet, so contrary to Tsuji's experiment, the hair wasn't cosmetically correct just yet.

It's not the question if bio generated HF's will produce human hair or if the HF's will grow on human skin. We're already past that man. The only problem left is creating DP cells. If Jahoda improves his method, or that Tawanese trial is a success, or Tsuji finds a way to induce IPS cells into DP cells, or Li's group reaches it first then hairloss problems are a thing of the history.

[strife91]

I think you've just not read up to the subject. Tsuji lab created a HF that produced human hair with all cosmetically correct charateristics, albeit on a mouse skin. Jahoda repeated that with cultured cells, again human hair but this time even on human skin

It's not the question if bio generated HF's will produce human hair or if the HF's will grow on human skin. We're already past that man. The only problem left is creating DP cells. If Jahoda improves his method or Tsuji finds a way to induce IPS cells into DP cells, then hairloss problems are a thing of the history.

Thankyou for explaining this arashi cos otherwise I'd be clueless lol

[hellouser]

I think you've just not read up to the subject. Tsuji lab created a HF that produced human hair with all cosmetically correct charateristics, albeit on a mouse skin.

DNA analysis revealed that the hair was 100% human.

Last year, Jahoda repeated that experiment, but not with existing cells, with cultured cells (!!!), again human hair but this time even on human skin, albeit gene expression was not high enough yet.

It's not the question if bio generated HF's will produce human hair or if the HF's will grow on human skin. We're already past that man. The only problem left is creating DP cells. If Jahoda improves his method, or those Tawanese trial is a success, or Tsuji finds a way to induce IPS cells into DP cells, then hairloss problems are a thing of the history.

Yeah but how do we go from that to getting the treatment without waiting '3-5, 10 or 30 years' ?? It'd be ridiculous if another biotech started FDA trials, we all know how long THOSE take. We need a shortcut, something like the black market compounds (RU58841, CB, etc).

[Arashi]

Yeah but how do we go from that to getting the treatment without waiting '3-5, 10 or 30 years' ?? It'd be ridiculous if another biotech started FDA trials, we all know how long THOSE take. We need a shortcut, something like the black market compounds (RU58841, CB, etc).

Once the science is out, there surely will be a 'black market' circuit in less developed countries, for the daredevils.

[inspects]

Once the science is out, there surely will be a 'black market' circuit in less developed countries, for the daredevils.

No doubt there.

Interesting articles though...thanks...!

[hellouser]

Once the science is out, there surely will be a 'black market' circuit in less developed countries, for the daredevils.

Everyone would have to be ultra careful about ending up going to a Nigam doctor.

I wonder if Universities with the lab equipment would be able to replicate the process; find a bio student with access that knows their shit and get them to do it. We'd need all the info in detail on the process made public.

Someone mentioned that all the equipment would cost around $10,000 to do what these guys are doing, culturing cells and all. I'm sure as a community we could all pitch in the money EASILY and do it ourselves with someone spearheading the execution of cell culturing and all (safety taken into account of course!). I'd pay GOOD MONEY to Desmon if he was capable. We all raise the money and then give Desmond extra for his work.