Human lung created in the lab

[Molten]

You're dead wrong again. I advise you to read up here: http://www.sangamo.com With their platform they can flip any gene on/off in any organism, including humans.

I'll definitely read that and comment further, thanks for posting that.

However, even if they can do that at this time, there is no way to know if the genes they are shutting off won't affect something else, which could lead to severe injury at best and death at worst. No one has any idea what genes are involved to cause MPB, and even if we did, we have no way to know if these same genes are also indirectly responsible for keeping your liver running.

[hellouser]

For starters, the hair on your back is your native hair. They have the exact same spatial regulation and structure as the hair follicles that are in the front. Engraftment essentially ruins all of that and in the end makes the engineered hair follicles vastly inferior to your natural ones. There is no method I know of that addresses this fundamental issue and all of them seemed to have ignored it. This along with a few other reasons is why they are failing and will continue to fail.

Of course, I'm open to the possibility that I'm wrong and will gladly come here and admit I am wrong if any one of these teams are successful. But, that possibility is increasingly remote.

What is 'engraftment' ??

[Molten]

What's missing in the human scalp for hair follicles to grow? Whats so different about scalp where MPB exists compared to the sides and back of the head where scalp is capable of growing hair NORMALLY?

For starters, the hair on your back is your native hair. They have the exact same spatial regulation and structure as the hair follicles that are in the front. Engraftment essentially ruins all of that and in the end makes the engineered hair follicles vastly inferior to your natural ones. There is no method I know of that addresses this fundamental issue and all of them seemed to have ignored it. This along with a few other reasons is why they are failing and will continue to fail.

Of course, I'm open to the possibility that I'm wrong and will gladly come here and admit I am wrong if any one of these teams are successful. But, that possibility is increasingly remote.

[Arashi]

Really simple gene therapies such as the ones you that simply alter enzyme levels are absolutely nothing in comparison to the truly complex gene therapy that would be required to cure baldness.

You're dead wrong again. I advise you to read up here: http://www.sangamo.com With their platform they can flip any gene on/off in any organism, including humans.

[Arashi]

That's still very different beast than growing hair on a human skull. Histogen and Replicel had amazing laboratory techniques and breakthroughs, but ended up proving the skeptical scientific community in the end by showing it simply can't be grown out of a human skull with any meaningful results.

They never got any results on human skin. Jahoda did. You can downplay that all you want, but human skin = human skin.

[Molten]

+1 cookies

Some people on this forum just like to throw random numbers and estimations without having any clue of what they are talking about just for the sake of sounding sensational and to reinforce their feeling of hopelessness.

It's not "random numbers and estimations" but a good understanding of the underlying science and how incremental our understanding of the problem has been for the past century. I have admitted again that I cannot foresee major breakthroughs, but it's very unlikely such a breakthrough will occur.

Practically every scientist and doctor not working in this field would agree with me. You think they have no clue of what they are talking about as well?

[Molten]

There is already one gene therapy approved by the EMA (Glyberia). But somehow it will take 300 years to have a gene thereapy for hair?

Really simple gene therapies such as the ones you that simply alter enzyme levels are absolutely nothing in comparison to the truly complex gene therapy that would be required to cure baldness. For starters, we have a complete understanding of what causes lipoprotein liapse deficiency and it's been well known for years to be caused by a mutation.

For baldness, we have no idea what combination of genes causes it, and there's no reason to think we will anytime soon. Also, there's no reason to think that even if we do, we'll instantly know which genes to manipulate without causing a real permanent damage.

The fact you think Glybera means gene therapy as a whole is just around the corner demonstrates your complete lack of understanding of the problems and genetics as a whole.

[hellouser]

That's still very different beast than growing hair on a human skull. Histogen and Replicel had amazing laboratory techniques and breakthroughs, but ended up proving the skeptical scientific community in the end by showing it simply can't be grown out of a human skull with any meaningful results.

Again, until he has demonstrated to the scientific community 90%+ hair regrowth in all his test subjects, he doesn't have a "cure".

What's missing in the human scalp for hair follicles to grow? Whats so different about scalp where MPB exists compared to the sides and back of the head where scalp is capable of growing hair NORMALLY?

[Molten]

Not sure what you mean ? Jahoda grew hair on human skin, albeit on transplanted human foreskin on SCID mice, but that serves as a very accurate model.

That's still very different beast than growing hair on a human skull. Histogen and Replicel had amazing laboratory techniques and breakthroughs, but ended up proving the skeptical scientific community in the end by showing it simply can't be grown out of a human skull with any meaningful results.

Again, until he has demonstrated to the scientific community 90%+ hair regrowth in all his test subjects, he doesn't have a "cure".

[hellouser]

is this guy for real? 300 years until a cure? this guy is Hellrouserx1000 with his negative posts. You cant even say his timelines are anything even remotely realistic.

Just to clarify, lol, I've never made projections of how long a cure would take. Nobody knows. I'm kind of with the mindset with Spencer Kobren; it'll get here when it gets here. What I am pissed off about though, is all the red tape and the snail pace progress. You want to take shots at me you may want to get your facts straight first. On *** I've clearly stated in another thread that it could be 3 years or it could be 30 years. None of us has a crystal ball.

[Arashi]

I dont really agree with most of this and it makes no difference since we all are essentially guessing

Of course it's guessing, but we can do it educated. We already know the recipe for the cure, it's already been shown to work, we just need a way to get enough of the ingredients (DP cells). Jahoda's method of culturing them needs improvement, he already made several suggestions in his paper which he thought would improve his method, things that made a lot of sense. The organ regenerative field is making enormous progress, clinical trials are starting now or have been starting lately in tons of related fields (like biogenerated skin and IPS cells) and people are even already walking around with stem cell lab generated organs (trachea's) since a few years now. It's an accumulative process which is going faster and faster. Of course nobody can exactly pinpoint when it will be done, but if you think it wont happen in our lifetime, then you're either 95 years old, suicidal or you're just ignoring all progress

[burtandernie]

I dont really agree with most of this and it makes no difference since we all are essentially guessing. No more treatments in our life times? CB 03 01 is in trials as we speak and less then a year for acne dont see some big reason why MPB wont pan out although it could. So I guess I dont have such a pessimistic view point.

[Arashi]

There is already one gene therapy approved by the EMA (Glyberia). But somehow it will take 300 years to have a gene thereapy for hair?

Sorry but this Molden guy doesn't know what he's talking about. Gene therapy 300 years away, LOL, like you said, there's already EU approved gene therapy available (http://www.uniqure.com/news/167/182/...ommission.html). He also might want to take a look here: www.sangamo.com it's an ultra precise platform to change any gene in any organism you want and they're currently in phase II trails to make people resistent to HIV/AIDS by changing some gene. But to do that for hair is 300 years away ?

But gene therapy is not the answer here. Why go messing around with genes when we can just bio-generate hair like Jahoda and Tsuji have been doing ? We're almost there ...

[fred970]

+1 cookies

Some people on this forum just like to throw random numbers and estimations without having any clue of what they are talking about just for the sake of sounding sensational and to reinforce their feeling of hopelessness.

[cookies]

Baldness will only truly be cured when we have reliable gene therapy, and that type of technology is at least 200-300 years i.e not in your great grandson's lifetime.

There is already one gene therapy approved by the EMA (Glyberia). But somehow it will take 300 years to have a gene thereapy for hair?