Sm04554

[Thinning@30]

Having a tough time accepting this, but I also want to wait for the official announcements before I jump to conclusions. I don't see why Samumed would go to the trouble of presenting at a conference not to mention all the "hinting" about decent results if they knew the results were actually lackluster and were considering not moving forward with SM04554. Wouldn't it make more sense to just quietly shut down the project and move on? Then again, Aderans and Washenik were totally enthusiastic about ARI right up until the day they liquidated the lab sold off the equipment.

This whole thing feels just like what happened when Replicel first announced their trial results. Huge letdown and then months later they released a bunch of statements trying to convince us that things weren't as bad as they looked.

I'm grasping for ways to maintain hope here. Could SM04554 give truly effective maintenance if not regrowth? Will results be better at six months or one year? Could it have a synergistic effect with minox or fin? Could it be used with hair transplants to make transplants a better option?

[mayapple]

Having a tough time accepting this, but I also want to wait for the official announcements before I jump to conclusions. I don't see why Samumed would go to the trouble of presenting at a conference not to mention all the "hinting" about decent results if they knew the results were actually lackluster and were considering not moving forward with SM04554. Wouldn't it make more sense to just quietly shut down the project and move on? Then again, Aderans and Washenik were totally enthusiastic about ARI right up until the day they liquidated the lab sold off the equipment.

This whole thing feels just like what happened when Replicel first announced their trial results. Huge letdown and then months later they released a bunch of statements trying to convince us that things weren't as bad as they looked.

I'm grasping for ways to maintain hope here. Could SM04554 give truly effective maintenance if not regrowth? Will results be better at six months or one year? Could it have a synergistic effect with minox or fin? Could it be used with hair transplants to make transplants a better option?

3 MONTHS and every one is depressed and losing hope. It was stupid of them to announce results after such a short period of time. I am assuming they did so because of trial regulations, or promoting their company or some crap. Hair cycling and growth is painfully slow. Fin takes up to a year to see results. Minoxidil six months to a year. Lets calm down and see what happens before throwing in the towel.

[dm90]

Honestly after thinking about it, I'm feeling positive about all if this. I mean 90 days is really way to short, but we still saw a minor improvement. I could see them going into a large phase 3 trial with application for 12 straight months. I really think they will continue with the trials. But I do hope they do mutliple control groups, with at least one group using sm and fin. I think combination therapy is imperative.

[allTheGoodNamesAreTaken]

OK, so 10 hairs per square cm isn't anything too exciting... BUT it's ten more hairs than any snake-oils have been capable of. Maybe different doses, maybe more time required to see better results, maybe used in combination with something else. At the very least it confirms the science that motivated trying this approach. In fact... forget about regrowth, even just a reliable maintenance would be great. If that's what this turns out to be, I'll take it.

[TravisB]

OK, so does anyone know when they will publish the official presentation?

There will probably be pics included

[bboyforever]

I'm not sure why no one has pointed this out yet, but the obvious question is how these results scale. We could be talking:

10% at 3 months
20% at 6 months
40% at a year
80% at 2 years

You've got to keep in mind we're dealing with a new pathway here that is about as downstream the cascade as we've ever gone. There's been some good solid theory about why other treatment modalities hit a brick wall, and it's usually because of some downstream effect. The limiting effect here might just be the physical growth rate of the hair follicle itself.

Everyone is assuming these results are logarithmic, that they taper off, (like fin and minox). What if, in fact, they're linear? Good god, what if they're exponential?

Until some guys actually start dropping some science about what these results actually mean, taking the most facile and pessimistic view is really people wallowing in playing whiny victim bitches. And don't start posting all your little emotional tantrums because your emotions don't mean shit, I just want the data.

[dus]

This product would be great for me as an add on to fin. If it gets released within 2 years I will be very happy. NW 7's are ****ed and should just accept it imo. Stop wasting your time on these depressing forums. If you really want hair as a 7... do the front + mid at a proper clinic and accept the bald spot on the back. My two cents.

[Tomtom21]

theres so many negative thoughts regarding this since weve been burned so many times in the past.
first point the trial was breif 3 months... not really adequate time to assess how good of regrowth agent this is.
second point it definitely created skme regrowth 10% which is eh but if we kitchen sink our heads 10 from sm 10 from cb plus maintenance plus 20 from min is 40%. you cant expect this to be an end game cure gotta keep your hopes realistic. also this product would obviously be better for diffusers. realistically we need a product that can create greater regrowth so HT can be more aesthetic at this stage in the game.
the one negative that worries me is the poor dose response curve and how it plateued at such a low dosage. hang tight my fellow baldies

[Dimoxynil]

This product would be great for me as an add on to fin. If it gets released within 2 years I will be very happy. NW 7's are ****ed and should just accept it imo. Stop wasting your time on these depressing forums. If you really want hair as a 7... do the front + mid at a proper clinic and accept the bald spot on the back. My two cents.

If your a NW7 you should go for an SMP/FUE combo IMO it's almost a no brainer

[baldybald]

If your a NW7 you should go for an SMP/FUE combo IMO it's almost a no brainer

Completely agree

[burtandernie]

I think we need to see 12 month results before drawing conclusions. Not sure whats the point in even releasing 3 months results its almost meaningless because results can change so much in 6 more months. Everyone responds differently, but it takes a lot longer then 3 months

[Seuxin]

Hello Guys,

Do we have the formula, or a new patent ??
I ask this in order to know if we can copy it ?

SO, they go on P3 ?

[joel203]

does anyone have any sort of an idea when we will hear an official statement from sammumed ? I also heard on the *** forum that someone said theyre reconsidering dosage so are starting things from scratch? can anyone confirm this

[allTheGoodNamesAreTaken]

If your a NW7 you should go for an SMP/FUE combo IMO it's almost a no brainer

This is something I've been wondering about because SMP on its own looks shit when close up (and the hairlines I've seen are generally awful too) and obviously won't feel like little hairs if touched... but getting a diffuse-ish FUE done and with SMP sounds plausible. Not quite sure why this isn't a popular thing already... maybe there should be a thread on it if there isn't one...

[Dimoxynil]

This is something I've been wondering about because SMP on its own looks shit when close up (and the hairlines I've seen are generally awful too) and obviously won't feel like little hairs if touched... but getting a diffuse-ish FUE done and with SMP sounds plausible. Not quite sure why this isn't a popular thing already... maybe there should be a thread on it if there isn't one...

From what I've seen just browsing SMP forums, the results can look VERY good. Just having some real hair around the hairline can give a very realistic look. I saw one guy who used just 800 grafts to replicate a hair line and the rest was standard tricopigmentation. I'm quite amazed that there's no great interest in it on here.