Sm04554

[Hemo]

How often does this chemical get applied? Once a day?

I believe the trials have been once per day but who knows until it's potential release.

[machi]

after the disappointment of yesterday the results of CB- 03-01 , is it possible to get samumed in the same way that we can use CB- 03-01 ? I mean if we can get samumed in Kane or another laboratory.
I can not wait any longer , I 'm going bald and I can not go outside without toppik .

[dm90]

I'm cautiously optomistic about this drug. I found this article that links miRNA 214 with hair cycling and forming via the WNT/B-catenin.

miR-214 exhibits differential expression patterns in the skin epithelium, and its inducible overexpression in keratinocytes inhibited proliferation, which resulted in formation of fewer HFs with decreased hair bulb size and thinner hair production.

That sounds like hair miniaturization to me.

The inhibitory effects of miR-214 on HF development and cycling were associated with altered activities of multiple signaling pathways, including decreased expression of key Wnt signaling mediators β-catenin and Lef-1, and were rescued by treatment with pharmacological Wnt activators.

Sorry if this was already posted. Ive read the entire thread a few times, but alot of stuff has been posted and I cant remember every single study. I dont know if this is linked to AGA, but there are multiple studies that show that DHT significantly inhibits WNT/b-catenin in DP cells of men with AGA, it does not do this to men without AGA. The first study I posted seems to say that the HF cycling and development problems can be RESCUED with WNT activators. Would any of you hard science guys like to take a stab at this? My molecular biology is a bit rusty.

[IvanXproject]

after the disappointment of yesterday the results of CB- 03-01 , is it possible to get samumed in the same way that we can use CB- 03-01 ? I mean if we can get samumed in Kane or another laboratory.
I can not wait any longer , I 'm going bald and I can not go outside without toppik .

I guess it would be possible if they released the chemical structure

And if they don't, we'll have to wait until 2018/2019... which is way too long in my opinion

[BoSox]

I can not wait any longer , I 'm going bald and I can not go outside without toppik .

I'm with you. I needed something 5 years ago.... now I'm a NW 2.5ish with serious diffuse thinning, it's taking more and more derrmach to cover it.

Can we at least get a medication to reverse what we have now before we ****ing lose it? CMON.

[IvanXproject]

Is it likely that they will release their chemical structure next saturday?

[Hemo]

Is it likely that they will release their chemical structure next saturday?

Very unlikely IMO. Why the hell would they?

[dutchguyhanging]

I'm with you. I needed something 5 years ago.... now I'm a NW 2.5ish with serious diffuse thinning, it's taking more and more derrmach to cover it.

Can we at least get a medication to reverse what we have now before we ****ing lose it? CMON.

look, always said and will say again. there is NO such thing as to reverse what you have now. thats for the likes of fin +minox...etc

as long as there is no cure coming out, we will ALWAYS lose ground... without doubt..

so again there WILL BE NO such medicine that will guarantee you to maintain what you have...

[IvanXproject]

Very unlikely IMO. Why the hell would they?

Idk man...

I just want to get a hold of this before 2018...

Maybe the structure is in here: http://www.google.com/patents/US20140080902

[BoSox]

look, always said and will say again. there is NO such thing as to reverse what you have now. thats for the likes of fin +minox...etc

as long as there is no cure coming out, we will ALWAYS lose ground... without doubt..

so again there WILL BE NO such medicine that will guarantee you to maintain what you have...

Your saying we can't reverse thinning hair, unless we have Fin or Minox? What about SM04554? Isn't that a better Fin or Minox?

[Hemo]

Your saying we can't reverse thinning hair, unless we have Fin or Minox? What about SM04554? Isn't that a better Fin or Minox?

Jesus, you've been here since 2010 and still believe these kinds of claims? We have no idea how effective SM04554 is. Did anyone conclusively say it is? No.

People are excited because researchers claimed it's poised to move into phase III. Hopefully that means it's better but no one has a clue at this point.

[dutchguyhanging]

Your saying we can't reverse thinning hair, unless we have Fin or Minox? What about SM04554? Isn't that a better Fin or Minox?

no i am saying as long as u dont make NW0 from NW7, all treatments will go down the drain. u need a full proof cure.

in other words, there will be always side effects if u dont come up with full cure. because u r not tackling the real issue.

as you may think, SM might be better than Fin for SOME PEOPLE. however FIN will still show better results for the other. they wont be statistically different of each other

aging plays a role in hair loss thats why SM needs to show hell alot of better results than this. I am not convinced at all with the hype.

[dm90]

look, always said and will say again. there is NO such thing as to reverse what you have now. thats for the likes of fin +minox...etc

as long as there is no cure coming out, we will ALWAYS lose ground... without doubt..

so again there WILL BE NO such medicine that will guarantee you to maintain what you have...

Except there are plenty of studies that show the persistent benefits of long term finasteride use. Yes I'm aware of the drop in hair count at the five year mark, however you have to remember that there is still 10% type II in the DPC. I would be willing to wager that drop in hair count would not occur in a long term dutasteride study. AGA has a very complex pathology, but there are still major players in its development. DHT is without a doubt the strongest driving factor that we've discovered. The reason I'm excited about WNT/B-catenin modulation is because it has the potential to be another major player in AGA. Specualtion is completely pointless, we will know the results in five days.

[burtandernie]

I have never been fully convinced aging causes MPB. If it was every man and woman would be affected, but its clearly not the case. There are men and women that are like 60 with almost zero hair loss. Clearly its something yet to be understood, and I do think androgens are a huge huge player in it. We dont even really have a perfect AA to even look at for an ideal scenario of what androgens really do. Maybe dut but even that spikes T a lot which is also an androgen so even dut isnt perfect

[champpy]

We are just 3 days away from getting an idea if SM is going to be a savior or just a slight upgrade from current treatments.

I for one am getting nervous as hell, im so afraid that if we get any photo proof it will be underwhelming. This is really the only thing we may have in the next 2 years, i think we all need to send good vibe out this weekend, hope for the best but be prepared for the worst.

Please dont let is down Samumed