Sm04554

[seanway]

But if we use something topically with low half life it should be a matter of concern isnt ? I hope SM04554 will have nice result.

[lacazette]

Well they used it once daily in the trials, so let's hope their level activation is strong enough. Maybe severe hair loss sufferers will be able to use it twice daily ^^

In mouse just one topical Wnt activation induced anagen phase of the HFs, whereas 6 applications not only induce anagen phase, but also lead to ectopic HF formation from existing ones.


another study mentioning Wnt, 2014

The Wnt/β-catenin pathway plays an important role in the initiation, development, and growth of hair follicles.
The transient activation of β-catenin results in hair regrowth in mice, while ablation of β-catenin results in dramatic hair shortening and abnormal regeneration of hair in the dermal papilla of mouse hair follicles [19, 33]. The levels of β-catenin in the dermal papilla are high in the anagen phase but low in the catagen and the telogen phases [18, 34]. Furthermore, the interaction between β-catenin, androgen receptors, and keratinocyte growth inhibition through modification of Wnt signaling contributes to androgenic alopecia, a common form of hair loss

[champpy]

I read earlier in this thread that Samumed is the 3rd largest sponsor of the Hair Conference. Can anyone tell me if this is their first time as a sponsor? Also, who are the other two sponsors that are ahead of Samumed?

If this is their first time, and they have a large presence, this tells me that they may actually have something they want to announce.

[xyz123]

I read earlier in this thread that Samumed is the 3rd largest sponsor of the Hair Conference. Can anyone tell me if this is their first time as a sponsor? Also, who are the other two sponsors that are ahead of Samumed?

If this is their first time, and they have a large presence, this tells me that they may actually have something they want to announce.

First time they've been a sponsor. And Women's Rogaine and Procter & Gamble are the top 2.

http://www.hair2015.org/

[nameless]

We should be contacting our US senators and asking them to rush approve the 21st Century Cures Act. Anyone who does not do this is not helping to overcome baldness. Anyone who does not do this is a slacker who does what he can to contribute to the cause of defeating baldness.

[nameless]

First time they've been a sponsor. And Women's Rogaine and Procter & Gamble are the top 2.

http://www.hair2015.org/

Proctor and Gamble does not even have a respected treatment for hair loss.

What a bunch of jerks.

[failly]

I have found two interesting articles coming from 2013. Don't know if these links are already posted.

http://www.uphs.upenn.edu/news/News_Releases/2013/12/millar/

http://www.nature.com/jid/journal/v133/n1/full/jid2012446a.html

[champpy]

While they may not have a respected treatment, P&G a huge company. Rogaine (while absolute poo in my mind) is a household name.

I really cannot think of any other reason why Samumed would be such a large sponsor if they didn't have something they are trying to promote. Am I wrong on this? If I am, can someone please tell me why else they would be part of the conference ?

[champpy]

While they may not have a respected treatment, P&G a huge company. Rogaine (while absolute poo in my mind) is a household name.

I really cannot think of any other reason why Samumed would be such a large sponsor if they didn't have something they are trying to promote. Am I wrong on this? If I am, can someone please tell me why else they would be part of the conference ?

[nameless]

While they may not have a respected treatment, P&G a huge company. Rogaine (while absolute poo in my mind) is a household name.

I really cannot think of any other reason why Samumed would be such a large sponsor if they didn't have something they are trying to promote. Am I wrong on this? If I am, can someone please tell me why else they would be part of the conference ?

I agree with you. I don't think Samumed would waste time and other resources on the Hair Loss Congress if their product isn't a significant improvement over the existing treatments (propecia, dutasteride, and Rogaine).

[maver1ck]

While they may not have a respected treatment, P&G a huge company. Rogaine (while absolute poo in my mind) is a household name.

I really cannot think of any other reason why Samumed would be such a large sponsor if they didn't have something they are trying to promote. Am I wrong on this? If I am, can someone please tell me why else they would be part of the conference ?

Common sense would say yes, they have something to promote so they obviously spend what money they can to get the 3rd sponsorship spot. We KNOW they have something, but we just dont know how effectively it works. With that being said why promote yourselves when you know your product doesn't even work? If we can believe those people on this thread with knowledge of clinical trials (and I dont really see why any laymen shouldnt) then there really is something to the second round of testing and maybe they will make a full scale announcement.

[lacazette]

Proctor and Gamble does not even have a respected treatment for hair loss.

What a bunch of jerks.

You're right dude, but they are supporting several labs research like this one for example in Southampton university, so not surprising to see they are a sponsor of the event:

http://www.ngcm.soton.ac.uk/projects/Microstructural-modelling-of-skin-mechanics.html

Microstructural modelling of skin mechanics

"The project aims to gain a mechanistic insight into the biomechanics of the skin, particularly around hair follicles via the development of advanced multiscale constitutive equations and micromechanical models integrated into a multiphysics finite element environment.

The project is supported by Procter&Gamble
the results of the PhD project have the potential to impact the life of hundreds of millions of male and female consumers across the globe."

[Renee]

Didn't aderans do a phase 2b to take punch biopsies like sm is doing now? Look at what happened to them.

[macbeth81]

If I am not mistaken Aderans had multiple, smaller Phase 2 trials to test different protocols. They were doing trial/error approach to see what worked (nothing). For SM04554 the two Phase 2 trials use the same protocol, but the second one is taking biopsies (pre/post application). They didn't take biopsies at the beginning of the initial trial, thus they need to start the trial over to get the initial, pre-treatment biopsies.

[champpy]

We KNOW they have something, but we just dont know how effectively it works. With that being said why promote yourselves when you know your product doesn't even work?

Thats a question id love to ask the makers of rogaine