Sm04554

[Hubris]

Ten hairs on a 1 cm squared surface area. That's not great but it's something. Dosing looks like it could be an issue though.

Yes, ten hairs in a 1cm squared surface area. Let's be realistic, these results are a massive disappointment, and it's unlikely now that this drug will ever come to market.

[Cartech78]

I know it sucks that this study didnt produce better results , part of me was hoping for more then we got too, but every time companies do these studies more is learned then we knew before and i believe that it inches us closer to a cure. Picture what 10 hairs would look like in a 1cm square looks like! That is better in my opinon then what minoxidil has ever done for me .

[BoSox]

Trash results. Especially if this drug isn't coming out for at least two years. I'm officially done with this forum, nothing is coming out within the next few years unless it's a miracle. Not going to waste my youth anymore on this bs.

[jamesst11]

it sucks, but you're dismissing it too soon. 10 hairs / cm2, after THREE months... who even gives a sh*t after three months?? How long did it take you to REGROW TERMINAL HAIR on finasteride, minoxidil, etc... sure there are always some amazing responders, but this showed halt of loss and 10% regrowth in 3 months, and through a completely different pathway. I am actually impressed. That is because I keep my expectations extremely low.

[willy]

10 hairs in 1cm square at 3 months? What about 6 - 12 months, while the hair cycles? If they're vellous hairs than this is nonsense.. but terminal ? Maybe not THAT bad? If it works in the hairline / temples that would be ok too imo.

[beetee]

We all want an overnight cure and a guarantee but unfortunately that's not on offer and not often the way scientific research advances. If we're alive and a cure comes out, we're really lucky; no other bald/balding people from previous generations have had that opportunity. If it's working on any level, that's good. If they're continuing to do research, that's good. This isn't a set back. We have the same thing we had yesterday; they've done research, they've had some positive results, and they're going to keep working at it.

[beetee]

Also, I get the impression that the Forbes piece was not written in response to the actual presentation but based on a preview they received from Samumed before the conference. For those reacting very negatively, I would suggest at least waiting until we get access to some of the materials and information that were actually presented at the conference itself, not just this preliminary review.

[Trouse5858]

We all want an overnight cure and a guarantee but unfortunately that's not on offer and not often the way scientific research advances. If we're alive and a cure comes out, we're really lucky; no other bald/balding people from previous generations have had that opportunity. If it's working on any level, that's good. If they're continuing to do research, that's good. This isn't a set back. We have the same thing we had yesterday; they've done research, they've had some positive results, and they're going to keep working at it.

I just can't share the optimism. We're lucky if a cure comes out when we're [B]alive[B]? So if you're 65 years old, and the "cure" comes out, that's a victory in your mind? Even though it won't have any affect on your life?

All I want is a goddamn treatment that can slow down my hairloss without castrating me so I don't have to worry about my hairloss every time I go to the beach, or a bar, or ride in my friends jeep with the roof off. Until then, I'm just going to be completely unable to enjoy most activities to the fullest. Maybe 70 percent, while the other 30 is worried about how shitty I look. That might be ridiculous and shallow but it's a fact and nothing about my willpower can change it.

[Tenma]

Shit, didnt expect those numbers.

The only hope is the time frame, 3 months is too early for most treatments.

Maybe it can show better results on lower NWs also?

[IvanXproject]

Maybe we could get this made in a laboratory? (like CB, RU, Seti etc.)

It will probably work better on lower NWs and if you use it for a longer period of time

[beetee]

I just can't share the optimism. We're lucky if a cure comes out when we're [B]alive[B]? So if you're 65 years old, and the "cure" comes out, that's a victory in your mind? Even though it won't have any affect on your life?

All I want is a goddamn treatment that can slow down my hairloss without castrating me so I don't have to worry about my hairloss every time I go to the beach, or a bar, or ride in my friends jeep with the roof off. Until then, I'm just going to be completely unable to enjoy most activities to the fullest. Maybe 70 percent, while the other 30 is worried about how shitty I look. That might be ridiculous and shallow but it's a fact and nothing about my willpower can change it.

I hear you and I feel your pain, but there's no reason to think there ever will be a cure. They could try for a 1,000 years and never be able to crack it. What if it's impossible? That could very well be the situation. So, yes, if we experience a cure in our lifetimes, that would definitely be amazing. I don't know if you're relatively new to this or not (it's all relative, I'm not trying in any way to diminish your experiences) but I've been dealing with it for 16 years so I know the difficulties involved in trying to live your life not being consumed by the fact that you can't enjoy activities to the fullest. Got to do the best you can to make what you have work for you though; it's still your life and you have to live it for as long as you're alive, and it's going to go by one way or the other. If being pissed and upset about it grew back hair, trust me, I'd be walking down the street during a hurricane with the proudest, thickest pompadour you've ever seen!

Also, I know strategically employing hats in challenging environments can feel like you're crossing a line that you'd rather not but my life got about a million times easier when I started pulling one out for the kind of situations you mentioned.

[Tenma]

Also, I get the impression that the Forbes piece was not written in response to the actual presentation but based on a preview they received from Samumed before the conference. For those reacting very negatively, I would suggest at least waiting until we get access to some of the materials and information that were actually presented at the conference itself, not just this preliminary review.

Reading the article again, it is certain he wrote it before the presentation.

But the data was apparently reviewed by doctors who had previous access to the presentation

I think we should wait for official info before rushing into conclusions

[Waiting4Cure]

I have been lurking this forum for 4 years now and after subpar results of other drugs (CB, Bim, Seti, etc) I am eagar to hear any news on SM04554.

Granted, "only" 10 more hairs from 1cm squared is a very minor improvements and can be disappointing to hear at first sight.

However, we gotta remember that they only recruited NW4+ patients for their Phase 2 study and its result is only at 3 months.

This means that results can get much better if you are below NW4 and take it for more than 3 months as most implanted hairs don't even grow in 3 months.

Also, avg pt hair density per 1cm squared was 110 hairs thus 10 hairs was a 10% increase of density.

Last but not least, the placebo group had decrease of hairs (5 hairs) which suggests that SM can maybe maintain hairs as well.

Overall not the greatest result we all anticipated but still too early to cross SM off our list as others are saying here.

[dm90]

I'm still interested in Sammumeds official statement and results on the drug. Because the forbes article also says they are trying to proceed into further trials for approval. I'm not speculating on anything but if the results were really that poor, I cant imagine them continuing with trials. Hopefully we will here something from them soon.

[Spaniards]

Hi! I still think they can make it, thatīs not a significant improvement but let them do their job. It has been only a three months trial, so please do not draw conclusions from that.

I have read something about April in a different forum. What are they gonna do then? Any clue? Thanks guys and do not give up, we are on this together! We all want a cure, but it seems we have to wait... At least for a while!