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yes, most dermatologists will have you believe that, giving 80 mg to a 150lb teen kid for sure "screw you up pretty good!". LOL
when given in high amounts yes. The dose is dependent on body-weight. isotretinoin used at 20 mg per day for 5-6 months is a cure for acne for 95 % + people.
Low-dose isotretinoin in the treatment of acne vulgaris.
Amichai B, Shemer A, Grunwald MH.
Source
Huzot Clinic of Clalit Health Services, Ashkelon, Israel.
Abstract
BACKGROUND:
The efficacy of isotretinoin at 0.5 to 1.0 mg/kg per day in the treatment of acne is well established and considered safe, although it is sometimes not easily tolerated because of its cutaneous side effects.
OBJECTIVE:
The purpose of this study was to determine the efficacy of low-dose isotretinoin in the treatment of acne.
METHODS:
In this prospective, noncomparative, open-label study, 638 patients, both male and female, with moderate acne were enrolled and treated with isotretinoin at 20 mg/d (approximately 0.3-0.4 mg/kg per day) for 6 months. The patients were divided into two age groups: 12 to 20 and 21 to 35 years old. Patients were evaluated at 2-month intervals by means of clinical and laboratory examinations. A 4-year follow-up was also carried out.
RESULTS:
At the end of the treatment phase, good results were observed in 94.8% of the patients aged 12 to 20 years, and in 92.6% of the patients aged 21 to 35 years. Failure of the treatment occurred in 5.2% and 7.4% of the two groups, respectively. Twenty-one patients dropped out of the study because of lack of compliance, and another patient discontinued participation because of a laboratory side effect. During the 4-year follow-up period, relapses of the acne occurred in 3.9% of the patients aged 12 to 20 years and in 5.9% of the patients aged 21 to 35 years. Elevated serum lipid levels (up to 20% higher than the upper limit of normal value) were found in 4.2% of the patients and abnormal (<twice the upper limit of normal values) liver tests were observed in 4.8%.
LIMITATIONS:
This was a noncomparative, open-label study.
CONCLUSION:
Six months of treatment with low-dose isotretinoin (20 mg/d) was found to be effective in the treatment of moderate acne, with a low incidence of severe side effects and at a lower cost than higher doses.Comment
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It could act differently then a normal AA like propecia if you read the article. We only need one good safe topical AA whether this or CB to basically make MPB a preventable problem. Why its taken 20 years to get something like this since propecia I really dont know but better late then never
page 3 bright green letters
"By inhibiting androgen and PGD2 synthesis nitric
oxide may have multiple mechanisms that can be exploited to treat male pattern baldness."Comment
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Its unbelievable the slow pace of AGA treatments. Apparently 2016/2020 its going to be this new "era" of topical antiandrogens. RU studies are from the early-mid 90s! Which means scientist and biotechs companies were both aware of how to prevent this ****in' problem.
Hell, since Hamilton studies we know the impact of androgen suppression on hair mantainance.
SB-204 will come sooner than CB, hopefully. They plan to present phase 2 results early next year. I'm a little angry with cosmo, though. they restarted trials with cb despite their phase two success in europe.
If we use this stuff together and maybe add finasteride we can certainly lower the androgen stimulus sufficient enough for a very long time.Comment
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There is no such thing as a nw7+ lol. Your pessimism is keeping you away from common sense. If you are nw 4-7, you should wait for pilofocus. Topicals alone probably wont make the difference.Right,but you will be nw7+ when this comes outComment
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Like someone else was saying I think a huge part of why so many topical AAs fail to work that well is just lack of penetration and absorption. I think stuff like topical spiro and other treatments that exist right now would work many times better if they had better delivery systems like with Iontophoresis that cosmo used in their studies where a few things besides just CB worked really well.Comment
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How long until this comes out like 2015 maybe? Man that seems short when your talking approval, but 2 years is such a long time. I might have to try propecia I dont know if I can wait that long. Then its for acne so it probably wont even work for MPBComment
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just use RU. which is a local antiandrogen. until something better comes alongComment
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I would love to use RU, but I have a few issues. Safety? Reliable supplier? Good vehicle that works? If your wrong on any of this you could be in big trouble. If some reliable place sold it and there were some decent study showing it doesnt go systemic I would have been taking it a long time agoComment
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LOL once again, acnea before MBP. This is a ****ing joke. I'm going crazy.
Imagine a topical AA. Not only people with MBP will buy it but all the paranoid people who think losing their hair because they have seen one in their shower. And that every month. This is BILLIONS OF DOLLARS !
SO WTF?!Comment
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Well I dont know that kane is reliable I mean I dont even know how a person tests that. They are licensed, inspected annually for conditions, and all of that? Its a complicated thing here in the US if they are overseas its a whole different ball game. How do you know it never goes systemic if it even gets absorbed well enough to work? Its just too many unknowns to me to be worth using because its just as risky if not more so then propecia. Again just IMO I could be wrong im not an expert on any of this its not my job or hobbyComment
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A proven topical that is generally safe is what we all have been waiting for you could just take it for the hell of it in case you might go bald years from then. It would make picking a treatment worth using a whole lot easier.Comment
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