Reason why there is still no cure in 2013 and the solution

[hellouser]

As soon as any one of these 'researchers' releases a treatment the public can have, I'm going all out with some crazy hairstyles.... like this one:



I say 'researchers' in quotations because I can't take them TOO seriously when they're this slow on finding a cure.

[Arashi]

Guys please don't clutter this thread. This thread was a real great thing by Desmond, he really was right in pinpointing the core of the problem and where we currently stand and I'd really love to hear Desmond's opinion on my questions, let's focus on that here.

[hellouser]

Guys please don't clutter this thread. This thread was a real great thing by Desmond, he really was right in pinpointing the core of the problem and where we currently stand and I'd really love to hear Desmond's opinion on my questions, let's focus on that here.

You know, looking at the big picture... what good is all the talk we're doing? It really accomplishes nothing. Whats needed to be done is to kick these researchers in high gear and tell them to hurry the hell up. Every single one of us wants a fix right now. The real focus should be about getting these 'researchers' to start executing rather than constantly ramble on about '3-5' years crap. Let's assume that these researchers actually have sympathy for us... what do they need to get everything done? What could we do besides speculate to help them?

[Arashi]

what good is all the talk we're doing?

Well obviously pretty much nobody here on this forum is in a position to solve the puzzle (except maybe for somebody like Boldy). However this thread is a good one since it pinpoints where we're currently at and what's holding us back from a cure. Understanding that is important cause we, as the balding community, can then have a better idea of how close we are and what steps are yet to be taken.

Desmond was right. I re-read Tsuji's paper's and Jahoda's finding. All that's between us and a cure are DP cells. They regulate all intrinsinic hair properties. When Tsuji lab grew *human* hair on mice, the hair was the same as the hair from the donors. They just took existing DP cells. When Jahoda cultured those DP cells, they lost 78% of gene expression. The 22% left was enough to retain the hair inducing ability but the intrinsic properties like colour were gone. So it's either about increasing the gene expression when culturing or get iPS cells to become DP cells. If any of those 2 venue's come to a success, then hairloss is a thing of the past. Everything apart from this last piece has been solved already. It's the only thing left between us and a cure. And not some 'histogen' a la 20% more hair cure, but a REAL cure. Unlimited hair for everybody.

[Arashi]

We hear time and time again, conspiracy theories about Big Pharma holding out on the cure or the society wanting us to stay bald...BUT that is not true. The fact of the matter is, we are stuck on one final step (a crucial step)...Once we figure it out, the rest of the way has been paved for us by groups like Tsuji team and Lauster!

After reading those papers, I came to the exact same conclusion. This is spot on Desmond. And this thread is therefore one of the best threads on this forum, period. Thanks for pointing this out !

To me, this felt like something awesome to know. Cause all the researchers in the field will now focus on that last, final but crucial step. I now do understand why everbody in the scientific community is so optimistic about a cure in the near future !! Of course, clinical trials will be needed, so we'd still be talking about a lot of time, but once that final step has been taken, I'm going to pop the champagne !!!

[Jazz1]

I found the cure for Alopecia Areata for me and 7 others, I get time I will document all my proof and evidence as it's very long, unfortunately it didn't cure my MPB! All I can say since curing my AA I truly believe our diseases can be cured through water and food, our environment is probably the cause of all this shit! Just like it was causing me to get AA!

[Arashi]

I found the cure for Alopecia Areata for me and 7 others, I get time I will document all my proof and evidence as it's very long, unfortunately it didn't cure my MPB! All I can say since curing my AA I truly believe our diseases can be cured through water and food, our environment is probably the cause of all this shit! Just like it was causing me to get AA!

It's been scientifically proven for a long time that it's a genetic thing.

[cichlidfort]

I found the cure for Alopecia Areata for me and 7 others, I get time I will document all my proof and evidence as it's very long, unfortunately it didn't cure my MPB! All I can say since curing my AA I truly believe our diseases can be cured through water and food, our environment is probably the cause of all this shit! Just like it was causing me to get AA!

Dude, I've seen homeless men on the streets that have FULL heads of hair that have many nutrient deficiencies. Based off your theory, all homeless, people with bad diets etc would have poor hair quality and that is NOT true. It's genetic...bro. Ignorance I swear.

[Jazz1]

Well its funny you say that because I have the Aloepcia areata aswell from my dad's genes, funny how I cured this aswell as them . I'm not here to argue any facts with anyone I'm telling you guys simple and clear i also have the AA gene and simple cure was water softner, it's like a switch i turn the softner off and within days I get AA patches, I turn it back on and my patches regrow back.

[cichlidfort]

Well its funny you say that because I have the Aloepcia areata aswell from my dad's genes, funny how I cured this aswell as them . I'm not here to argue any facts with anyone I'm telling you guys simple and clear i also have the AA gene and simple cure was water softner, it's like a switch i turn the softner off and within days I get AA patches, I turn it back on and my patches regrow back.

I was referring to MPB. I don't know much about AA.

[cichlidfort]

Well obviously pretty much nobody here on this forum is in a position to solve the puzzle (except maybe for somebody like Boldy). However this thread is a good one since it pinpoints where we're currently at and what's holding us back from a cure. Understanding that is important cause we, as the balding community, can then have a better idea of how close we are and what steps are yet to be taken.

Desmond was right. I re-read Tsuji's paper's and Jahoda's finding. All that's between us and a cure are DP cells. They regulate all intrinsinic hair properties. When Tsuji lab grew *human* hair on mice, the hair was the same as the hair from the donors. They just took existing DP cells. When Jahoda cultured those DP cells, they lost 78% of gene expression. The 22% left was enough to retain the hair inducing ability but the intrinsic properties like colour were gone. So it's either about increasing the gene expression when culturing or get iPS cells to become DP cells. If any of those 2 venue's come to a success, then hairloss is a thing of the past. Everything apart from this last piece has been solved already. It's the only thing left between us and a cure. And not some 'histogen' a la 20% more hair cure, but a REAL cure. Unlimited hair for everybody.

Say hypothetically someone solves the last step with culturing and maintaining gene expression with the DP cells tomorrow. Then, how long are we talking? I hear a lot of speculation saying the real cure (referring to this one) is about 8-10 years away. Are those speculators just assuming that it's going to take another 5 years to figure out and then about 3-4 years of clinical trials/funding etc? Not sure how the logistics work after the cure has been figured out. I would assume whoever figures out the real cure will get mad funding almost instantly once it has been proven. But like I said, say they find the missing piece to the puzzle tomorrow, would it be only a few years away until it becomes available? I know this is utter speculation and I'm aware speculation pisses people off but it's honest curiosity because I don't get the whole 8-10 year timeline.

[Jazz1]

I was referring to MPB. I don't know much about AA.

You ever questioned yourself why lab rats bald, I wouldn't be surprised if these geeky scientists were switching different genes to cause them to lose Fur, I'm sure they can switch off our hairloss genes, again my theory on what I believe is different to you guys, as the softner is like a switch for 7 of us that cured AA. After all those clever derms and scientists stated there's no cure for AA, yet it's funny how a simple thing like a softner cured our alopecia areata disease from my dads side.

[Arashi]

Say hypothetically someone solves the last step with culturing and maintaining gene expression with the DP cells tomorrow. Then, how long are we talking? I hear a lot of speculation saying the real cure (referring to this one) is about 8-10 years away. Are those speculators just assuming that it's going to take another 5 years to figure out and then about 3-4 years of clinical trials/funding etc? Not sure how the logistics work after the cure has been figured out. I would assume whoever figures out the real cure will get mad funding almost instantly once it has been proven. But like I said, say they find the missing piece to the puzzle tomorrow, would it be only a few years away until it becomes available? I know this is utter speculation and I'm aware speculation pisses people off but it's honest curiosity because I don't get the whole 8-10 year timeline.

I think 3-4 years for a clinical trial like this is really an underestimate. It's probably going to be 6-7 years. And who knows, problems may arise. But it seems most researchers in the field now seem to think that figuring out this last step is going to take 2-3 years. Washenik concluded his thesis 2 months ago with: "Recent developments in the field of regenerative medicine indicate that a cell-based solution for alopecia is coming soon." which of course is based on the fact that we're just 1 step away now (fixing those DP cells). But who knows, it's impossible to say. All I know is that it's the last step and I'm popping the champagne when that step is completed, regardless how long clinical trials will take

[walrus]

You ever questioned yourself why lab rats bald, I wouldn't be surprised if these geeky scientists were switching different genes to cause them to lose Fur, I'm sure they can switch off our hairloss genes, again my theory on what I believe is different to you guys, as the softner is like a switch for 7 of us that cured AA. After all those clever derms and scientists stated there's no cure for AA, yet it's funny how a simple thing like a softner cured our alopecia areata disease from my dads side.

If you can do a better job than the 'clever derms' and 'geeky' scientists, why don't you publish your findings and enlighten them all?

[Jazz1]

If you can do a better job than the 'clever derms' and 'geeky' scientists, why don't you publish your findings and enlighten them all?

I will I recently fell ill and number two il start on here as iv been posting on hairlosshelp. I have nothing to sell I'm not recommending any product I'm simply stating the water softner was the cure for 7 of us not to mention my hairdressers mum has stopped her hairloss. It's thanks to him my Aloepcia areata is cured and I will contact the papers. But to be honest there's to many IGNORANT people that think I'm a bullshitter, and frankly I couldn't care less I won't stop posting the truth about my story regardless what people think as I know one thing, those idiot derms and doctors never cured me they just gave me stupid useless steroid creams and me being out pocket on money.