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Like every study says, maybe in another 5 years....
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Don't know about any of you, but I'm not excited in the least.
This turning into an actual application is years and years away. 5 years probably at the least. Lol.
Let's talk about what we do have now...the devil's drug Propecia, and the skin-aging wonder Rogaine. Next topic please...Comment
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No pigment and no sebaceous glands is key. Those two are the toughest part. This thing is decades away, if ever, from being brought to market.Comment
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"Recently, a big breakthrough was made by Li and colleagues, who created human follicles from cultured dermal and epidermal cells in a nu/nu mouse model. In their initial work, TSC2 null fibroblasts were combined with foreskin keratinocytes in a skin construct model. Once a nascent epidermal basal layer was formed in vitro, the skin construct was grafted on the back of a nu/nu mouse. The continued development of the skin resulted in the formation of hair follicles and sebaceous glands. This work represents the first published account of the formation of human hair from cultured cells."
From "Future Horizons in Hair Restoration" by Dr Washenik
He then continued about Jahoda's work:
"In a separate system, Higgins and colleagues reported the formation of human hair using DP cells cultured as spheroids and combined with the epidermis of an excised human foreskin in a sandwich assay. For the first time, cultured human cells were used to form a completely human hair follicle. The expansion of these techniques provides a potentially unlimited supply of hair for the treatment of alopecia."
It seems this is what he's referring to: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108033/
Of course Li's work doesn't have to mean it works in 100% human skin, but it does sound promising.Comment
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Yep, Sebaceous gland is what actually helps hair break through the skin.
Generation of skin appendages in engineered skin substitutes has been limited by lack of trichogenic potency in cultured postnatal cells. To investigate the feasibility and the limitation of hair regeneration, engineered skin substitutes were prepared with chimeric populations of cultured human keratinocytes from neonatal foreskins and cultured murine dermal papilla cells from adult GFP transgenic mice and grafted orthotopically to full-thickness wounds on athymic mice. Non-cultured dissociated neonatal murine-only skin cells, or cultured human-only skin keratinocytes and fibroblasts without dermal papilla cells served as positive and negative controls respectively. In this study, neonatal murine-only skin substitutes formed external hairs and sebaceous glands, chimeric skin substitutes formed pigmented hairs without sebaceous glands, and human-only skin substitutes formed no follicles or glands. Although chimeric hair cannot erupt readily, removal of upper skin layer exposed keratinized hair shafts at the skin surface. Development of incomplete pilosebaceous units in chimeric hair corresponded with upregulation of hair-related genes, LEF1 and WNT10B, and downregulation of a marker of sebaceous glands, Steroyl-CoA desaturase. Transepidermal water loss was normal in all conditions. This study demonstrated that while sebaceous glands may be involved in hair eruption, they are not required for hair development in engineered skin substitutesComment
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One very important fact we must mention is Tsuji lab's technology desperately needs to come up with a technique to multiply DP cells to several orders of magnitude and maintain their trichogenicity.
(Their technology requires combination of epithelial stem cell & DP cells)
Tsuji team is following these developments very closely and undoubtedly with a great deal of interest.
Very positive news, even though we had received snippets of it back in March during the World Hair Research Congress.Comment
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just one more reason
I have follow a lot of threads in this forum. I have been suffering a lot due to the hair transplant i did. Insted of getting better selfesteem it went even wors.
The Only thing i feeling When i read all the comments is sadness. All my good years are gone and the future don't look that Good.
Why keep fighting i Will always feel ugly, dumb and bitter!! Buuhuu yeah thats f*Ing pathetic i know but those "doctors" has really ruined my life and no solution seems to come in the near future.
Over and out!Comment
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fail
CrapComment
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What don't people think about using meds, concealers, FUE's, SMP and other solutions already available to buy time then wait if something new comes out to restore what they lost afterwards. If it's a money problem I don't get it. Do you really think those new solutions down the line will be cheap?!Comment
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I think Nigam is on to something. He is very open about his technique (as attested by Mwamba and Dr Cole's rep). Whether it's as good as he seems to think remains to be seen, but the possibility of getting a HT with a much larger volume of donor would be huge.
I'm hoping for this as I do not want to wait years more for a cellular treatmentComment
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From the atricle:
"Whenever human tissue was taken from the dermal papillae, the cells which form the base of each hair follicle, the cells would transform into skin instead of growing new hairs.
However, the group found that by clumping the cells together in "3D spheroids" they would keep their hairy identity."
From the limited information I have, this sounds similar to what Dr. Nigam is doing.
35YrsAfter also posts as CITNews and works at Dr. Cole's office
forhair.com
Cole Hair Transplant
1045 Powers Place
Alpharetta, Georgia 30009
Phone 678-566-1011
email 35YrsAfter at chuck@forhair.com
Please feel free to call or email me with any questions. Ask for ChuckComment
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