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Glycolic Acid Scalp Peel [Follicular-hyperkeratosis]
I feel this is noteworthy, and deserving of its own discussion.
"The pathogenesis of male-pattern-baldness (MPB) is the same as acne. The first step in acne is a condition called follicular-hyperkeratinization or hyperkeratosis. Simply put, this means excess skin production inside and around the hair-follicle. The next step is caused by excess sebum production, followed by P.Acnes infestation of the pilosebaceous-follicle, with subsequent inflammation. So to summarize, MPB, just like acne, is caused by four main factors: (1) follicular-hyperkeratinization, (2) excess sebum production, (3) P.Acnes, and (4) inflammation [1].
Free-IGF-1 (insulin-like-growth-factor-1) stimulates the proliferation of keratinocytes (skin cells below the scalp). As the keratinocytes mature, they migrate to the top of the scalp and become what is known as corneocytes. If all goes well, the corneocytes are supposed to be shed off the scalp in a process called apoptosis. The shedding of corneocytes or the apoptosis of corneocytes, is under the influence of IGFBP-3 (insulin-like-growth-factor-binding-protein-3) and endogenous retinoids. In men with male-pattern-baldness, they have excess free-IGF-1 and not enough IGFBP-3 [2]. The result of this is hyperkeratinization; too much skin production, and not enough skin exfoliation. This causes the hair-follicle to be blocked by excess skin. Free-IGF-1 is required for keratinocyte proliferation in humans [3] and too much IGF-1 results in hyperkeratosis [4].
So, in order to reverse hyperkeratosis, exfoliating the scalp is needed. Using glycolic-acid topically is suggested. Glycolic-acid is what's called an alpha-hydroxy-acid. Alpha-hydroxy-acids are shown to diminish corneocyte cohesion, induce exfoliation and reverse hyperkeratosis. This should promote regrowth.
Source: http://www.acne.org/messageboard/top...eresting-read/
User experience #1:
Source: http://immortalhair.forumandco.com/t...-great-results
User experience #2:
Source: http://www.hairlosshelp.com/forums/m...threadid=61217
There are more case studies scattered elsewhere. While anecdotal, I find them interesting.The growth gonzalito experienced well below his temporal recession, if true, is impressive.
Maybe a scalp peel could be used as an adjunct treatment to derma rolling? Or would this be overkill?
Glycolic acid can be found on ebay for 15$, in the skincare section.
"The pathogenesis of male-pattern-baldness (MPB) is the same as acne. The first step in acne is a condition called follicular-hyperkeratinization or hyperkeratosis. Simply put, this means excess skin production inside and around the hair-follicle. The next step is caused by excess sebum production, followed by P.Acnes infestation of the pilosebaceous-follicle, with subsequent inflammation. So to summarize, MPB, just like acne, is caused by four main factors: (1) follicular-hyperkeratinization, (2) excess sebum production, (3) P.Acnes, and (4) inflammation [1].
Free-IGF-1 (insulin-like-growth-factor-1) stimulates the proliferation of keratinocytes (skin cells below the scalp). As the keratinocytes mature, they migrate to the top of the scalp and become what is known as corneocytes. If all goes well, the corneocytes are supposed to be shed off the scalp in a process called apoptosis. The shedding of corneocytes or the apoptosis of corneocytes, is under the influence of IGFBP-3 (insulin-like-growth-factor-binding-protein-3) and endogenous retinoids. In men with male-pattern-baldness, they have excess free-IGF-1 and not enough IGFBP-3 [2]. The result of this is hyperkeratinization; too much skin production, and not enough skin exfoliation. This causes the hair-follicle to be blocked by excess skin. Free-IGF-1 is required for keratinocyte proliferation in humans [3] and too much IGF-1 results in hyperkeratosis [4].
So, in order to reverse hyperkeratosis, exfoliating the scalp is needed. Using glycolic-acid topically is suggested. Glycolic-acid is what's called an alpha-hydroxy-acid. Alpha-hydroxy-acids are shown to diminish corneocyte cohesion, induce exfoliation and reverse hyperkeratosis. This should promote regrowth.
Source: http://www.acne.org/messageboard/top...eresting-read/
User experience #1:
My experience: for the last 3 weeks, I've been using a 20% glycolic-acid lotion on my scalp every other day. In between days of scalp peel, I massage the scalp with a cheap body massager (sample: http://shopping-digital.com.ar/wp-co...ador-TURBO.jpg) in order to remove the dead-skin-cell "build-up" from my scalp. The massager does the job properly: while massaging, you could see dead skin falling as snow!
The results: I´m regrowing hair in areas where I thought it never would regrow again... It´s really an interesting approach and I am eager to see better results with each successive peeling...
I was wondering to try a 30% concentration, although it´s better to stick with "don´t fix it if ain´t broke" Wink
A recent pic of my receding hairline:
The results: I´m regrowing hair in areas where I thought it never would regrow again... It´s really an interesting approach and I am eager to see better results with each successive peeling...
I was wondering to try a 30% concentration, although it´s better to stick with "don´t fix it if ain´t broke" Wink
A recent pic of my receding hairline:
User experience #2:
Source: http://www.hairlosshelp.com/forums/m...threadid=61217
There are more case studies scattered elsewhere. While anecdotal, I find them interesting.The growth gonzalito experienced well below his temporal recession, if true, is impressive.
Maybe a scalp peel could be used as an adjunct treatment to derma rolling? Or would this be overkill?
Glycolic acid can be found on ebay for 15$, in the skincare section.
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