is Histogen going to start phase 2b any time soon?

[Desmond84]

Hey guys,

This might be a long shot but considering how much money we throw away on snake oil, I really think this may be worth a small community trial!

Why don't we trial the "ReGenica Advanced Rejuvenation Overnight Repair" on our hairlines for 3 months and see what happens! It has almost all the growth factors that Histogen's HSC has after all...we're just not injecting it! If you remember, this was Histogen's first product launched

It's actually on sale at the moment for $132 after a 25% discount

http://www.essentialdermcare.com/ReGenica-Advanced-Rejuvenation-Overnight-Repair.html

[HairBane]

So, am i supposed to look at histogen phase 2a results and masturbate?

what the hell is going on with this company

why are they even doing another phase 2 if they don't have enough funding/time for it?

It's so annoying

I agree that the pictures didn't look that impressive, but the numbers were decent (I think around 20% increase in density?). They're going to try and see if increasing the dosage below toxicity point increases efficacy too. What you have to remember is that the cases in these trials used HSC and HSC alone for the entire period, and they had a slight improvement rather than getting balder. Maybe when it comes out, combining it with one of the current treatments (fin/minox) or other cutting edge treatments (maybe Nigam could use it with his hair multiplication techniques?) could be a really effective treatment, we don't know yet.

[Atum]

If i still have around the same amount of hair within a few years when histogen launches, i'd definitely get a procedure done if it's around $1000 bucks or so.(obviously i hope its less).

That's the worrying part, a few years.
I would be happy to pay a $1000 to cure my baldness.

[hellouser]

Hey guys,

This might be a long shot but considering how much money we throw away on snake oil, I really think this may be worth a small community trial!

Why don't we trial the "ReGenica Advanced Rejuvenation Overnight Repair" on our hairlines for 3 months and see what happens! It has almost all the growth factors that Histogen's HSC has after all...we're just not injecting it! If you remember, this was Histogen's first product launched

It's actually on sale at the moment for $132 after a 25% discount

http://www.essentialdermcare.com/ReG...ht-Repair.html

Can you name the specific growth factors that are in it? I'm willing to try it but I'd like to know what we're going to be using thats going to make all the difference.

Here's the ingredients list for the product:

Water, Caprylic/Capric Triglyceride, Squalane, Butylene Glycol, Methyl Gluceth-20, Glycerin, Butyrospermum Parkii (Shea Butter), Cetearyl Alcohol, Arachidyl Alcohol, Human Fibroblast Serum Free Conditioned Media, Laminaria Angustata Extract, Cocos Nucifera (Coconut) Oil, Dipotassium Glycyrrhizate, Galactoarabinan, Ceramide 3, Cetearyl Glucoside, Arachidyl Glucoside, Retinyl Palmitate, Ascorbic Acid, Sodium Hyaluronate, Xylitol, Beeswax, Arginine, Bisabolol, Behenyl Alcohol, Hydroxyethyl Acrylate/ Sodium Acryloyldimethyl Taurate Copolymer, Bis-Ethoxydiglycol Cyclohexane 1,4-Dicarboxylate, Salicylic Acid, Panthenol, Phenoxyethanol, Caprylyl Glycol, Xanthan Gum, Ethylhexylglycerin, Hexylene Glycol, Diso dium EDTA, Polysorbate 60, Citrus Aurantium Dulcis (Orange) Oil, Citrus Medica Limonum (Lemon) Peel Oil, Citrus Nobilis (Mandarin Orange) Peel Oil, Citrus Tangerina (Tangerine) Leaf Oil, Citrus Reticulata (Tangerine) Peel Oil, Mentha Viridis (Spearmint) Leaf Oil, Myrtus Communis Oil, Citral, Limonene.

[Scientalk56]

I agree that the pictures didn't look that impressive, but the numbers were decent (I think around 20% increase in density?). They're going to try and see if increasing the dosage below toxicity point increases efficacy too. What you have to remember is that the cases in these trials used HSC and HSC alone for the entire period, and they had a slight improvement rather than getting balder. Maybe when it comes out, combining it with one of the current treatments (fin/minox) or other cutting edge treatments (maybe Nigam could use it with his hair multiplication techniques?) could be a really effective treatment, we don't know yet.

I do think Histogen results are good, but i hate their timeline.. I will be totally bald when they release their product..Their phase 2a finished in 2012.. we're heading toward 2014 and still no news about the nest phase.

and about trying stuff (desomnd's post) i'm totally against it.

[Pentarou]

and about trying stuff (desomnd's post) i'm totally against it.

Yeah, looks like cosmoceutical garbage, and expensive.

If any community trial it needs carrying out, it needs to be 1.) the dermarolling/minox study, but with more participants 2.) anything practically viable (and safe) that we can construct from reading the recent UPenn and Follica patents.

[Artha]

Dr. Gail Naughton,, Founder, Chairman and Chief Executive Officer at Histogen will close out the US Stem Cells & Regenerative Medicine Congress.

http://www.terrapinn.com/2013/stem-cells-usa-regenerative-medicine/index.stm

Extremely compelling photo evidence of positive results shown by Dr Naughton, CEO Histogen.

[hellouser]

http://www.terrapinn.com/2013/stem-c...cine/index.stm

Extremely compelling photo evidence of positive results shown by Dr Naughton, CEO Histogen.

Those are some seriously NICE results on the skin. I hope their results with hair are just as substantial.

[garethbale]

Not for hair loss though

[Artha]

World Stem Cells and Regenerative Medicine Congress USA 2013

http://blogs.terrapinn.com/total-biopharma/2013/10/01/speed-fda-approval-process-cell-therapies/

Mohammad Heirdaran, PhD, from the FDA’s Office of Cellular, Tissue and Gene Therapies, CBER, provided cell therapy product manufacturing considerations to gain FDA licensure. His advice could be broken down to two main points : [1] know your product’s critical quality attributes (CQA) and critical process parameters (CPP). Reducing the sources of variability will simplify your interactions with the FDA. [2] Become cGMP (current Good Manufacturing Practices) compliant as soon as possible. He stressed that it is never too early since it may take a long time to reach cGMP compliance. In general, Dr. Heirdaran emphasized the importance of follow through with risk assessments by using tools to identify and rank parameters in the manufacturing process. Following these guidelines will speed progress towards consistent manufacturing for a high quality product, which means faster FDA licensure.

[UK_]

Can you name the specific growth factors that are in it? I'm willing to try it but I'd like to know what we're going to be using thats going to make all the difference.

Here's the ingredients list for the product:

Water, Caprylic/Capric Triglyceride, Squalane, Butylene Glycol, Methyl Gluceth-20, Glycerin, Butyrospermum Parkii (Shea Butter), Cetearyl Alcohol, Arachidyl Alcohol, Human Fibroblast Serum Free Conditioned Media, Laminaria Angustata Extract, Cocos Nucifera (Coconut) Oil, Dipotassium Glycyrrhizate, Galactoarabinan, Ceramide 3, Cetearyl Glucoside, Arachidyl Glucoside, Retinyl Palmitate, Ascorbic Acid, Sodium Hyaluronate, Xylitol, Beeswax, Arginine, Bisabolol, Behenyl Alcohol, Hydroxyethyl Acrylate/ Sodium Acryloyldimethyl Taurate Copolymer, Bis-Ethoxydiglycol Cyclohexane 1,4-Dicarboxylate, Salicylic Acid, Panthenol, Phenoxyethanol, Caprylyl Glycol, Xanthan Gum, Ethylhexylglycerin, Hexylene Glycol, Diso dium EDTA, Polysorbate 60, Citrus Aurantium Dulcis (Orange) Oil, Citrus Medica Limonum (Lemon) Peel Oil, Citrus Nobilis (Mandarin Orange) Peel Oil, Citrus Tangerina (Tangerine) Leaf Oil, Citrus Reticulata (Tangerine) Peel Oil, Mentha Viridis (Spearmint) Leaf Oil, Myrtus Communis Oil, Citral, Limonene.

Where is WNT7a? That's the active component of HSC.

Ascorbic acid might be beneficial as it reduces DKK1.

As for this idea, it's completely useless if you're going to throw out the gene therapy aspect (WNT 7A).

[yeahyeahyeah]

Those are some seriously NICE results on the skin. I hope their results with hair are just as substantial.

This IS WHY histogen hsc will hit the market.

Histogen have already released A product that has also gone through 3 clinical phases, why can't they release another one?