(CB-03-01 Vehicle Research) PhD Student in Chemistry

[kmit028]

Is there anywhere that sells a premade RU solution like how hairloss talk sells a premade topical spiro? Im not mixing random chemicals in my basement guessing at what works. I also dont know if I want to wait a few years for the actual legit thing

here

http://anageninc.com/solutions/ru-solution-50ml.html

[burtandernie]

Thanks, but is this legal to buy and use in the US for hair loss? I want a good AA, but I was thinking more like a premixed solution not just the pure chemical. I have no idea what vehicle to use or how to make it nor do I want to attempt that
Im just a little impatient for some topical AA.

[kmit028]

Thanks, but is this legal to buy and use in the US for hair loss? I want a good AA, but I was thinking more like a premixed solution not just the pure chemical. I have no idea what vehicle to use or how to make it nor do I want to attempt that
Im just a little impatient for some topical AA.

Yes this is a premixed solution, RU Solution 50ML

http://anageninc.com/solutions/ru-solution-50ml.html

As for USA customs... Better someone from USA advise whether or not this can be imported. As far as I know it should be fine as many people are using RU now from USA.

You could also just place an order and see what happens, worst case you lose about $100... lol

[itssomuchfun]

Well I think it's been about 5 weeks now since I started using premixed CB from ID. My shedding has probably doubled in that time and this kind of shedding started immediately. Like I said in my previous posts, trying this was a bit of a last ditch effort because my hair has thinning so much on the top of my head that it's probably better that I shave it soon. Anyone here think it's a good sign that I'm shedding so much using CB? I keep thinking I should stick with it like Propecia users do when they have a shed.

[PatientlyWaiting]

Is anagen inc legit? How many of you vouch for it? And how long does 50ml last? What is the dosage?

[hellouser]

Is anagen inc legit? How many of you vouch for it? And how long does 50ml last? What is the dosage?

AnagenInc is a sister site of Kane. It should be just as legit.

[PatientlyWaiting]

AnagenInc is a sister site of Kane. It should be just as legit.

Thanks.

How long does 50ml last? What is the dosage?

I know you use RU, how is that going for you?

[HairBane]

Thanks.

How long does 50ml last? What is the dosage?

I know you use RU, how is that going for you?

Well 50mg per day (1ml of 5%) would last you 50 days.

[lifelonglearning]

Damn its been almost a year since this thread has been formed and still no luck finding a vehicle

[JZA70]

Damn its been almost a year since this thread has been formed and still no luck finding a vehicle

It's not like a bunch of basement dwellers are going to find it on their own. We would need a lab and a few skilled scientists.

[doke]

Why not kb solution for cb as yet we do not know what cosmo is a lotion or a cream.

[Swooping]

Why not kb solution for cb as yet we do not know what cosmo is a lotion or a cream.

You can use that perfectly fine. I don't know any argumentation why there needs to be a "special vehicle" considering the low molecular weight of CB plus that it is easy soluble and quite lipophilic. However you need to use a higher concentration than 1%, most likely in the range of 3-5%.

If you have read the full original study of cb-03-01; http://www.ncbi.nlm.nih.gov/pubmed/15646372

You will know that it is slightly less effective than cyproterone acetate. Cyproterone acetate is like cb-03-01 a steroidal anti-androgen and quite a long time on the market. Be aware though that if the proposed pharmacokinetics are not true, cb-03-01 can be pretty harsh in terms of health. More so than non-steroidal anti androgens. Steroidal anti-androgens for instance exert a toxic effect on the cardiovascular system. So it's a risk you are taking. Obviously this won't be the case if it REALLY doesn't go systematic as proposed.

Now about why you need to use 3-5% is quite simple.

A topical, non-steroidal androgen antagonist, PSK-3841 (formerly HMR-3841 and RU-58841), is being investigated in France by Proskelia for possible therapeutic value in AGA and acne. The compound was is Phase II clinical trials as of January 2004, and was originally researched by Roussel-Uclaf and Hoechst Marion Roussel. When compared with the antiandrogenic compound cyproterone acetate, PSK-3841 exhibited a 20% increase in AR binding. This compound binds to both the ligand and regulatory domains of the androgen receptor. PSK-3841 exerts allosteric binding effects and may provide a unique mechanism of action in the treatment of alopecia.

Although this is an in vitro assay, I think you can pretty much figure it out why 1% will never cut it for AGA. RU-58841 is as strong and most likely even stronger than cb-03-01. I don't see many cases where using 10mg RU yields results lol . Well I guess you get it by now. Roussel-Uclaf were pretty much pioneers in discovering these extremely strong anti-androgens they also discovered RU-58642 which they wanted to use for baldness too, but never got past the initial stage. Probably because it is still the most powerful anti-androgen known to date lol; http://www.sciencedirect.com/science...60076097001519. Instant castration anyone? :P.

[doke]

You can use that perfectly fine. I don't know any argumentation why there needs to be a "special vehicle" considering the low molecular weight of CB plus that it is easy soluble and quite lipophilic. However you need to use a higher concentration than 1%, most likely in the range of 3-5%.

If you have read the full original study of cb-03-01; http://www.ncbi.nlm.nih.gov/pubmed/15646372

You will know that it is slightly less effective than cyproterone acetate. Cyproterone acetate is like cb-03-01 a steroidal anti-androgen and quite a long time on the market. Be aware though that if the proposed pharmacokinetics are not true, cb-03-01 can be pretty harsh in terms of health. More so than non-steroidal anti androgens. Steroidal anti-androgens for instance exert a toxic effect on the cardiovascular system. So it's a risk you are taking. Obviously this won't be the case if it REALLY doesn't go systematic as proposed.

Now about why you need to use 3-5% is quite simple.



Although this is an in vitro assay, I think you can pretty much figure it out why 1% will never cut it for AGA. RU-58841 is as strong and most likely even stronger than cb-03-01. I don't see many cases where using 10mg RU yields results lol . Well I guess you get it by now. Roussel-Uclaf were pretty much pioneers in discovering these extremely strong anti-androgens they also discovered RU-58642 which they wanted to use for baldness too, but never got past the initial stage. Probably because it is still the most powerful anti-androgen known to date lol; http://www.sciencedirect.com/science...60076097001519. Instant castration anyone? :P.

ho swoop why not use 1% iron dragon cb and try 2mls twice a day?

[burtandernie]

Whatever happened with RU-58642 why did these things never make it through to approval?

[Swooping]

ho swoop why not use 1% iron dragon cb and try 2mls twice a day?

You could. But are they legit? Only testing will answer that for you. Would be really expensive too I think to use at such a dosage.