(CB-03-01 Vehicle Research) PhD Student in Chemistry

[john2399]

*small update*

CB from Kane was shipped yesterday. Estimated arrival is August 20th.

Hellouser, how much stuff do you actually take ? lol it seems like you are on every single treatment to fight this shitty disease, which i dont blame.

[hellouser]

Hellouser, how much stuff do you actually take ? lol it seems like you are on every single treatment to fight this shitty disease, which i dont blame.

I've actually had limited use of stuff to fight my hair loss. To date, I've only done the following;

- Nizoral
- Saw Palmetto
- Minoxidil
- RU58841
- Dermarolling/Wounding

I'll soon be trying CB as you know. I've never touched finasteride, avodart, spiro, laser combs, etc. I only try the stuff that works and is relatively safe... and when I say that, I don't include Finasteride since its dick poison.

[534623]

A little bit about me. I am a PhD student at a leading institution in the world. I live in the UK ...

Oh no - Thomas Whitfield II ...

[534623]

I've actually had limited use of stuff to fight my hair loss. To date, I've only done the following;

- Nizoral
- Saw Palmetto
- Minoxidil
- RU58841
- Dermarolling/Wounding

[...] I only try the stuff that works ...

Sure. I mean, you would be an idiot if you would try stuff that doesn't work.

[hiilikeyourbeard]

how do we afford blackmarket cb though? the shit is like 400 bucks a month

[Knockin on NW4]

how do we afford blackmarket cb though? the shit is like 400 bucks a month

ummmmm...... no...

[hiilikeyourbeard]

ummmmm...... no...

how much then?

[thechamp]

What's the point in putting cb on your head without the correct Delivery??

[yan]

What's the point in putting cb on your head without the correct Delivery??

This negative attitude, unbelievable! Did you read the topic title? This thread is about searching a suitable vehicle through trial and error and some scientific informations...

[adam k]

Thank you so much Adam K for taking the time to do something about this disease. If you do end up finding something that actually works. Everyman on earth will be indebted to you!

I appreciate it brother, we are all in this together. We are a community who are doing this for the benefit of everyone just as much as we are doing it for ourselves. We are doing it with selflessness and pure intentions and THAT is what makes us unique and differ from the ulterior motivated, money hungry hair loss industry.

*small update*

CB from Kane was shipped yesterday. Estimated arrival is August 20th.

People here have much to be thankful for Hellouser. As I've said before, pharmaceutical companies have all kinds of tests they can carry out with complex advanced techniques and world class experienced staff. However we are lacking all of these so trials are the only way we can gauge success and Hellouser is leading the way. His motivation and courage is admirable.

[chimera]

What's the point in putting cb on your head without the correct Delivery??

That's exactly what we're trying to find dude!

[chimera]

Hellouser, I know you're going to star CB soon. Are you right now on RU?, if so, for how long pal?

[ragsta]

I came across this, any good for cb ? transdermal carrier for raw powder hormones.

http://phfsupplements.com/salvo-presale.html

weights of drugs:

Trestolone acetate : Molecular Weight: 330.465
DESOXY T ACETATE POWDER: Molecular Weight: 272.43

[adam k]

I came across this, any good for cb ? transdermal carrier for raw powder hormones.

http://phfsupplements.com/salvo-presale.html

weights of drugs:

Trestolone acetate : Molecular Weight: 330.465
DESOXY T ACETATE POWDER: Molecular Weight: 272.43

I have also been interested in transdermal steroidal delivery systems for a while now.

First of all I want to address something. From the structure of CB-03-01, I don’t think small amounts of water will affect the stability of the compound. The log P of CB is around 3.73 which indicate that it is insoluble in water but stability wise, any potential issues arise on C-17 regarding the ester group. Ester hydrolysis can occur, with the ester breaking down into alcohols and carboxylic acids. However hydrolysis is quite a slow and a very reversible reaction; without acid or base to "push" the reaction, it tends to be very insignificant. Also it is a tertiary ester which means attack by water molecules could be hindered so even better. However enzyme catalyzed hydrolysis CAN occur as the body has lots of enzymes that actively hydrolyze esters. I am a pure chemist (so someone correct me if I’m wrong) but isn’t that the beauty of CB as once it hits the bloodstream it changes to an inactive form.

From what I see the transdermal steroid carrier seems okay and viable. The carrier is a long chain alcohol which is good for hydrophobic molecules and CB is log P 3.73 which is quite hydrophobic.

[hellouser]

I have also been interested in transdermal steroidal delivery systems for a while now.

First of all I want to address something. From the structure of CB-03-01, I don’t think small amounts of water will affect the stability of the compound. The log P of CB is around 3.73 which indicate that it is insoluble in water but stability wise, any potential issues arise on C-17 regarding the ester group. Ester hydrolysis can occur, with the ester breaking down into alcohols and carboxylic acids. However hydrolysis is quite a slow and a very reversible reaction; without acid or base to "push" the reaction, it tends to be very insignificant. Also it is a tertiary ester which means attack by water molecules could be hindered so even better. However enzyme catalyzed hydrolysis CAN occur as the body has lots of enzymes that actively hydrolyze esters. I am a pure chemist (so someone correct me if I’m wrong) but isn’t that the beauty of CB as once it hits the bloodstream it changes to an inactive form.

From what I see the transdermal steroid carrier seems okay and viable. The carrier is a long chain alcohol which is good for hydrophobic molecules and CB is log P 3.73 which is quite hydrophobic.

Great stuff Adam!

One nagging question though; can CB in any way affect libido? And, given that its a steroid, what would its potential be to cause skin atrophy when applied at 10mg per 1ml once a day? Any concerns?