(CB-03-01 Vehicle Research) PhD Student in Chemistry

[Cob984]

Nano cb sounds retarded to me, isnt the whole point of nano advanced penetration which basically will increase the chance of systemic sides of topical AAs?
Makes no sense to me,
anyway i hope i am wrong and this is the answer

[lilpauly]

Nano cb sounds retarded to me, isnt the whole point of nano advanced penetration which basically will increase the chance of systemic sides of topical AAs?
Makes no sense to me,
anyway i hope i am wrong and this is the answer

it time-release the encapulated ingredients to the targeted areas , u can use 20 times less of the active ingredient as well . here is a study of dut in a liposome vehicle http://www.ncbi.nlm.nih.gov/m/pubmed/21513483/

"Dutasteride loaded liposomal system were developed for topical application in order to avoid the side effects associated with the oral administration of the drug"

[lilpauly]

i have yet to see a vehicle better then nanosomes. there is risk to using nay experimental lets make that very clear. u need a prescription to use promox for a reason. aLSO please take a look at the first person who ever used ru said


"I use a liposome base because the literature supports it and because it lessens the need for me to use the full amount cited in the stumptailed macaque studies. Admittedly the studies done utilized a 5% hydro-alcoholic solution were promising and showed that this type of vehicle worked. I just happened to be convinced that more of the drug can be delivered to the dermis level of the skin with a liposome and by hydrating the scalp."

[lilpauly]

here is a study of myristate rum in a liposome

http://www.ncbi.nlm.nih.gov/pubmed/15700772?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Acne and androgenetic alopecia are linked to androgen effects and therefore should improve following topical application of antiandrogens. We present a new antiandrogen prodrug, RU 58841-myristate (RUM) for topical therapy. Almost devoid of affinity to the androgen receptor, as derived from investigations in the mouse fibroblast cell line 29 +/GR +, RUM is rapidly metabolised to the potent antiandrogen RU 58841 by cultured human foreskin fibroblasts and keratinocytes, male occipital scalp skin dermal papilla cells, and by cells of the sebaceous gland cell line SZ95. In order to improve a specific targeting of the hair follicle, RUM was loaded on solid lipid nanoparticles (SLN), which are already known to support dermal targeting effects. Physically stable RUM loaded SLN were produced by hot homogenization. Penetration/permeation studies carried out using the Franz diffusion cell proved only negligible permeation of reconstructed epidermis and excised porcine skin within 6 h, implying a more topical action of the drug. Targeting to the hair follicle using SLN was visualised by fluorescence microscopy, following the application of Nile Red labelled SLN to human scalp skin. Transmission electron microscopy (TEM) allowed to detect intact silver labelled SLN in porcine hair follicles of preparations applied to the skin for 24 h. RUM loaded SLN should be considered for topical antiandrogen therapy of acne and androgenetic alopecia

[Hairismylife]

When here is full of desparate emotion these days, Lilpauly still posting useful info to us. Yes, we still have options. CB,dermarolloing+minox. Why in these days so many ppl become so pessimistic? All forgot CB & dermarolling? Cheers up!

[simba]

I got some good news and some bad news.

I emailed anageninc this :

Hi, will you be offering premixed cb-03-01 in a nano solution anytime soon?

and in reply i got this

Dear friend,

Thanks for your contact!

we'll be releasing specialized CB Gel for good penetration, as for now, Cb is not compatible with NAno technique pls note.

If you have any questions left, pls contact with us directly!
Warm regards,

Anagen inc

It seems nano doesnt work with cb, but if the gel works then who cares.

[KUP]

Oh so no-go on the nano-CB but instead they are making a gel that will also be premixed, right?
So for us it is basically a case of same but different i supposed.

[burtandernie]

After I see some more evidence from the actual CB trials showing its safe I might try this premixed CB depending on price since actual CB is years away still. I think CB is the big potential cure for MPB since if it can prevent mpb before it starts then its essentially a form of a cure. Its just a question of is it strong enough?
All the current stuff like like fin or dut change other hormones along with just DHT and the reason they might stop working could be based on receptors in hair which CB targets. Could be bigger then its currently thought.

[lilpauly]

Oh so no-go on the nano-CB but instead they are making a gel that will also be premixed, right?
So for us it is basically a case of same but different i supposed.

guys im real sorry i should have never mentioned nano cb or ru without having it produced first. both compounds were not possible, myristate rum was created because it had lipid tale and could be put in a nanosome.

[HairBane]

guys im real sorry i should have never mentioned nano cb or ru without having it produced first. both compounds were not possible, myristate rum was created because it had lipid tale and could be put in a nanosome.

no worries pauly, onwards and upwards

[inbrugge]

The CB gel is something I would be interested in if it is stable, effective, and doesn't enter the system. Who are Anagen Inc? Are they trustable? First time I'm hearing of them, albeit I'm learning about these experimental chems very recently.

Also, has anyone in the US ordered from these sites (Iron Dragon, Kane, MBPSolutions, etc). I was thinking about buying some powders and vehicles but I got a bit paranoid. I mean you gotta admit it wouldn't look all that good to someone who doesn't know what this stuff is, especially some customs inspector, etc.

[lilpauly]

The CB gel is something I would be interested in if it is stable, effective, and doesn't enter the system. Who are Anagen Inc? Are they trustable? First time I'm hearing of them, albeit I'm learning about these experimental chems very recently.

Also, has anyone in the US ordered from these sites (Iron Dragon, Kane, MBPSolutions, etc). I was thinking about buying some powders and vehicles but I got a bit paranoid. I mean you gotta admit it wouldn't look all that good to someone who doesn't know what this stuff is, especially some customs inspector, etc.

Hi man anageninc is Kane. It's his Europe office

[simba]

guys im real sorry i should have never mentioned nano cb or ru without having it produced first. both compounds were not possible, myristate rum was created because it had lipid tale and could be put in a nanosome.

Nanos not the goal, good penetration is the goal, lets just hope that this gel works well.

[locke999]

I have a feeling since nanogen didn't work, they are just coming out with the gel to not disappoint. I feel like it's just marketing.

[simba]

I have a feeling since nanogen didn't work, they are just coming out with the gel to not disappoint. I feel like it's just marketing.

Thats a possibilty, id like to know what the gel is made of and why they think itll work. Also why they didnt just use the same solution they used for RU.