(CB-03-01 Vehicle Research) PhD Student in Chemistry

[chimera]

Well i am never applying Cb ever again in an ethanol/pg vehicle,
My body is slowly coming back to normal, feels like coming off a bad trip,

Even RU was way way more tolerable,

So, you got sides on CB... even though CB does not interfere with your hormonal chemistry in any way...

And you also had sides on keratene... even though the blood test made by some forum members showed that it did not really worked reducing DHT...

[locke999]

So, you got sides on CB... even though CB does not interfere with your hormonal chemistry in any way...

And you also had sides on keratene... even though the blood test made by some forum members showed that it did not really worked reducing DHT...

He could be a hypochondriac but I think you shouldn't act as if you know for a fact CB is 100% safe. Even finasteride was thought to be safe but now we know its not.

[Cob984]

I am just very androgen sensitive? How the hell does RU give you sides? it also doesnt interefere with your hormones either in theory, obviously there is systemic absorption, please dont talk trash,

And RU gave me less sides than cb did, much less,
Maybe this is the wrong vehicle who knows,

[lothar99]

1) Keratene gave me awful sides, though they didn't feel bad in exactly the same as other things I have taken that lowered DHT.

2) RU definitely goes systemic. Pretty much anything you apply topically that manages to reach your hair will also enter your bloodstream. There are an ENORMOUS number of people reporting androgenic sides on RU. There is no way it is all metabolized before reaching androgen receptors in other parts of the body.

3) UN-METABOLIZED CB was present in blood plasma of 40% of trialists after application, although in very, very small portions. If someone was extremely susceptible to sides you could argue this small amount could cause them (less than 10 ng/ml). It was fully undetectable 24-36 hours after application in all trialists. However, that said, I am very sensitive to sides and CB's sides were very tolerable in me compared to other meds. I have not used form 3 CB yet, however.

[Cob984]

Lothar what vehicle did you use bro? eth/pg?

[hiilikeyourbeard]

could very well be the wrong vehicle for cb. we need to figure it out

[lothar99]

Lothar what vehicle did you use bro? eth/pg?

I tried a bunch of stuff to see what caused the least irritation/most immediate effects. various pg/acetone/glycerol or glycerine or something, I forget/ethanol/water in different combinations. I couldn't buy proper ethanol so I used the 70% with water/acetone/additives.

I want to try the form 3 patent cream vehicle or the liposome vehicle. Also want to try the nano vehicle, but nano isn't out yet.

[The Dark Knight]

I tried a bunch of stuff to see what caused the least irritation/most immediate effects. various pg/acetone/glycerol or glycerine or something, I forget/ethanol/water in different combinations. I couldn't buy proper ethanol so I used the 70% with water/acetone/additives.

I want to try the form 3 patent cream vehicle or the liposome vehicle. Also want to try the nano vehicle, but nano isn't out yet.

Do you think that depending on the vehicle used, it can cause CB to not metabolize properly and cause sides?

[lothar99]

Do you think that depending on the vehicle used, it can cause CB to not metabolize properly and cause sides?

I don't know much about vehicles, but I really doubt that. I mean, a vehicle could cause more or less of the drug to penetrate, and cause it to enter slower or faster. If it pushed it through to blood really fast maybe the body couldn't keep up rate of metabolism or something. Entirely speculation.

[yan]

3) UN-METABOLIZED CB was present in blood plasma of 40% of trialists after application, although in very, very small portions. If someone was extremely susceptible to sides you could argue this small amount could cause them (less than 10 ng/ml). It was fully undetectable 24-36 hours after application in all trialists. However, that said, I am very sensitive to sides and CB's sides were very tolerable in me compared to other meds. I have not used form 3 CB yet, however.

This is true but I just studied the hamster study and it says:

"CB was ineffective as antiandrogen when subcutaneously administered to rats up to a daily dose equivalent about to 100 mg/kg. The observed dissociation between the strong topical antriandrogenic activity and the absence of systemic effect could be explained supposing that, after subcutaneous injection, CB-03-01 undergoes a fast hydrolysis, by the liver or other tissues, leading to the inactive cortexolone form"

However this contradicts the reports from users here. At the moment I have no idea what to do beside waiting for official study results...

[yan]

And more:

"Considering that finasteride and flutamide were reported to induce a significant inhibition of hamster’s sexual accessory organs after topical application of low dose of about 0.25 mg/kg, and that bicalutamide displayed similar effects in rat after oral administration of 0.4 mg/kg, our data are very impressive and clearly indicate that the topical administration of CB-03-01 should not have systemic effects, on androgen-sensitive organs and functions, even in case of large percutaneous absorption."

[Cob984]

Vehicle has a huge effect,
this i know for a fact, because i can put 50 mg in 1 ml of kb and experience 0 sides,
but its also not really effective for the hair

[sdsurfin]

CB

I was using CB from an american lab (it was retardedly expensive), and it ran out in two weeks, but experienced no sides in ethanol/pg. There's a very slight possibility that it induced slightly more vivid dreams, so if anything i'd be worried about its effect on sleep, but definitely no sexual sides. "a slight tingle in the testicles" and "less frequent erections" are some pretty dubious sides, that could be cause by pretty much anything, and sound pretty hypochodriacal. also who really gives a **** if your ball is slightly tender, as long as it doesnt develop into something else. I was on fin and it gave me incredibly sore testicles, headaches, weak erections etc. A lot of people on fin have sore balls that go away after a bit. I stopped that shit because it really did make my head hurt whenever i took it, and made me feel generally poisoned, depressed, anxious, all of which went away after stopping. I really doubt CB gives serious side effects unless you're allergic to it or something, but these sides these users are describing seem like they are all in the head. any drug, even aspirin, is going to change things up in your body slightly. ask anyone over 25, and they'll tell you they get erections less frequently. The stress of hair loss alone can make your libido garbage. I would not be discouraged from trying CB, even in the two weeks i used it the itch went away completely, so at least as an anti inflammatory it seems to be useful. my hair loss isnt too bad yet and hard to gauge, so i'd be interested to know if it works wonders for people with rapid and very obvious loss.

[Cob984]

I just used some cb in ethanol/water vehicle with only half the dosage
same ****ing sides again, my sides arent much libido related, its this puffiness that rapidly appears, its as if my stomach bloats up instantaneously, my body shape just becomes really weird, dont know how to explain it

I get none of these sides using KB, this is really bemusing, i think the kb just destroys the cb molecule or what i dont know

[sdsurfin]

CB

that sounds like maybe some kind of allergy. also, pretty sure cosmo specified that CB should be in a non-aqueous vehicle. Maybe it's the ethanol that your body doesn't like. A lot of people get puffy on rogaine too. Plus who knows what the chinese are really selling you.