(CB-03-01 Vehicle Research) PhD Student in Chemistry

[Difthin]

Lothar gk got results on the wrong version lol anyways cb right now is not worth it until a vehicle can be found

Might be dumb, Im pretty much a noob in hairlossworld, but couldnt you use some kind of dermaroller with epidural (hollow) needles to get the stuff directly to the area where it needs to be? Im sure some one smarter than me would be able to create such a device. Just a thought.

[Knockin on NW4]

Oleyl seems to be an important penetration enhancer for CB. But everyone who has tried 9:1 PG to Oleyl says its way way too harsh, causing instant shedding, plus its super greasy.


Oleyl is Fatty, so it wont mix with ethanol. A couple of peeps are trying oleyl in emu oil for their CB vehicle. here is some number from a 2010 cosmo study


2010 cosmo study, page 74.

CA in PG 12.3ug/g skin concentration and penetration of undetectable
CA in PG/OL 89.4 ug/g concentration and penetration of 141ng/ml/hr
CB in PG 36 skin conc and penetration of 7
CB in PG/OL 231 skin conc and penetration of 1410

CB in 9:1 PG OLEYL on human skin in vitro

[burtandernie]

Why cant we just use this if it works and cosmo proved it worked? Im not a chemistry/biology person. So it uses propulsion and moves in electric field transdermally?

About iontophoresis
Iontophoresis is a non-invasive method of propelling high concentrations of a
charged substance, normally a medication or bioactive agent, transdermally by a repulsive electromotive force using a small electrical charge applied to an iontophoretic chamber containing a similarly charged active agent and its vehicle. One or two chambers are filled with a solution containing an active ingredient and its solvent, also called the vehicle. The positively charged chamber, called the anode, will repel a positively charged chemical,
whereas the negatively charged chamber, called the cathode , will repel a negatively charged chemical into the skin. Iontophoresis is well classified for use in transdermal drug delivery. Unlike transdermal patches, this method relies on ac
tive transportation within an electric
field

[chimera]

Gk is the only person who got good results with the Cosmo cream. At least 50 reported no rests

Ouch, that sucks

[lilpauly]

Lothar gk got results on the wrong version lol anyways cb right now is not worth it until a vehicle can be found

[lothar99]

If cosmo puts out CB on the market for acne will it work for hair loss? Or will they have to find an effective vehicle or will the vehicle be effective for hair loss because it is effective for acne?

The "cosmo cream" everyone used a few years ago was made wrong

[lilpauly]

I don't know man... lilpauli keeps saying the acne cream is no good, as it carries minaral oils which supposedly can't go through the hair shaft, but some time ago, a guy in this foum (I forgot who) told me that a guy in the SAGA tried CB on a replica of the acne cream and got awesome results...

Gk is the only person who got good results with the Cosmo cream. At least 50 reported no rests

[chimera]

If cosmo puts out CB on the market for acne will it work for hair loss? Or will they have to find an effective vehicle or will the vehicle be effective for hair loss because it is effective for acne?

I don't know man... lilpauli keeps saying the acne cream is no good, as it carries minaral oils which supposedly can't go through the hair shaft, but some time ago, a guy in this foum (I forgot who) told me that a guy in the SAGA tried CB on a replica of the acne cream and got awesome results...

[deuce]

If cosmo puts out CB on the market for acne will it work for hair loss? Or will they have to find an effective vehicle or will the vehicle be effective for hair loss because it is effective for acne?

[lilpauly]

lilpauly when will the Kane gel be available???

I don't know man Kane doesn't tell me much cause I tell forums. , when cb nano failed Kane got lots of emails regarding nano. I love nano products

[Hairismylife]

lilpauly when will the Kane gel be available???

[simba]

People who have used olyel alcohol seem to hate it

I guess that means you didnt use olyel?

If olyel has as good permeation as the iontophoresis device and also has the same results I could put up with only using it twice a week.

[yan]

Just some small new information regarding cb for alopecia:

• Completion of toxicological studies ongoing
• Phase I PK ongoing (treatment completed)
• Pre IND meeting with FDA scheduled for December 18

And a small update regarding cb for acne:

• Third cohort completed, fourth cohort recruiting, no major adverse
events to date

As we see, at least 1% cb (for acne) seems to be nearly side-effect-free.

http://www.cosmopharmaceuticals.com/~/media/Files/C/Cosmo-Pharmaceuticals/ir/presentations/2013-11-20/JefferiesGlobalHealthcare.pdf

[Stevo1]

since kane doesnt know the vehicle or iron dragon either, matter a fact know one does! . i hightly highyl sugget kane gives the gel out for free! i also know iron dragon used ethanol and thats just an awful vehicle.

FYI...lilpauly is right...bad/harsh alchohols are not good for some people.

25+ years ago i could use bad/harsh alchohols with no problem, but once my hair miniturized to a certain point I can no longer use these.

Case in point..I was on of the 1st to use Iron Dragon CB and it literally destroyed my hair after just ONE application...hence why I am waiting for kanes Gel or Cream

[lilpauly]

buy the way not been about here for a while who said that lasers do not work they are a great help for many forms of hair loss even the hair max which gave my hair a lot more body to it and some regrowth so for one i will be using my new igrow combined with a topical.
Also iron dragons new cb is 1% i think and its worth at least trying it before going to kane although i have used kane for ru and found the company very reliable its just the fact many of us are a bit lazy and to have a premixed solution is easy to use.
I was thinking of getting some cb from kane and mixing 3grams into 60ml kirkland minoxidil because that maybe a great combo if it mixs well that is but with a good shake i think it will and also shake every time you use.

since kane doesnt know the vehicle or iron dragon either, matter a fact know one does! . i hightly highyl sugget kane gives the gel out for free! i also know iron dragon used ethanol and thats just an awful vehicle.