(CB-03-01 Vehicle Research) PhD Student in Chemistry

[lilpauly]

In this study, we demonstrate the feasibility to use microneedle arrays manufactured from commercially available 30G hypodermal needles to enhance the transport of compounds up to a molecular weight of 72 kDa.

Piercing of human dermatomed skin with microneedle arrays was studied by Trypan Blue staining on the SC side of the skin and transepidermal water loss measurements (TEWL). Passive transport studies were conducted with Cascade Blue (CB, Mw 538), Dextran–Cascade Blue (DCB, Mw 10 kDa), and FITC coupled Dextran (FITC-Dex, Mw 72 kDa). Microneedle arrays with needle lengths of 900, 700 and 550 μm are able to pierce dermatomed human skin as evident from (a) the appearance of blue spots on the dermal side of the skin after Trypan Blue treatment and (b) elevated TEWL levels after piercing compared to non-treated human dermatomed skin. Microneedles with a length of 300 μm did not pierce human skin in vitro. Transport studies performed with model compounds ranging from 538 Da to 72 kDa revealed that pretreatment with microneedle arrays enhanced the transport across dermatomed human skin. However, some degradation was also observed for FITC-Dex and DCB. We conclude that assembled microneedle arrays can be used to deliver compounds through the skin up to a molecular weight of at least 72 kDa.

[DesperateOne]

After reading the whole thread for like 20+ minutes I had some laughs of the things people post lol, bribing someone into give us info haha. I have also been laughing for the last 30 minutes that how ironic it would be if snake oil turned out to be the correct vessel for this, I don't know why I found this so funny .

Well I do appreciate that we are doing this on our own. I however don't think that just hello should be doing the trials. First, he has a regular receding hairline and from what I gathered, those don't respond well. I say we need at least one that is a diffuse thinner to also be on the trial because if it doesn't work for Hell, he might just dump it.

Good luck.

[johnnynohair]

I'm going to be on this and reporting; need to get paid first though, never even occurred to me I couldn't use PayPal or cc until I started the order...

Ah well.

[hellouser]

I however don't think that just hello should be doing the trials. First, he has a regular receding hairline and from what I gathered, those don't respond well. I say we need at least one that is a diffuse thinner to also be on the trial because if it doesn't work for Hell, he might just dump it.

Good luck.

1) Nobody knows who responds well to CB, whether its diffuse thinners, guys with receding hairlines or crown thinning.

2) I am thinning all over, crown is thinning and general thinning everywhere else.

[hiilikeyourbeard]

we should arrange a group buy through Kane

[UK_]

Is the issue of the charged particles an issue of safety or delivery? I.e. Do Cosmo use this procedure to ensure the compound is safe or simply to improve absorbtion?

I would like to try CB but I'm worried about the safety, I understand there is nothing mutagenic associated with CB or the impurities, but what other saftey concerns should I be worried about before applying this treatment besides the fact that I'd be using an unapproved compound if I were to buy this stuff?

[yan]

Is the issue of the charged particles an issue of safety or delivery? I.e. Do Cosmo use this procedure to ensure the compound is safe or simply to improve absorbtion?

I would like to try CB but I'm worried about the safety, I understand there is nothing mutagenic associated with CB or the impurities, but what other saftey concerns should I be worried about before applying this treatment besides the fact that I'd be using an unapproved compound if I were to buy this stuff?

Well the clinical trials for acne are about to end soon. They reported no major side effects so far. Also the proof of concept for acne in europe showed no side effects.
According to cosmo, there are only minimal local or even no side effects at all.

They used this procedure in order to safe time and money and of course to improve absorbtion. CB for acne is the same in cream vehicle.

[yan]

save* :P

Although they use 1% CB for acne and 5% CB for alopecia, I don`t think there is a major difference in terms of side effects..

[UK_]

That's what I mean, we'd be using concentrations nearing 12 - 15% hence my concern.

I like how Adam breaks apart the molecule and looks for possible dangers at a deeper level, this is exactly the kind of research we need when determining true safety.

[hellouser]

That's what I mean, we'd be using concentrations nearing 12 - 15% hence my concern.

I like how Adam breaks apart the molecule and looks for possible dangers at a deeper level, this is exactly the kind of research we need when determining true safety.

Big fvcking kudos to Adam

THANK YOU!

[yan]

That's what I mean, we'd be using concentrations nearing 12 - 15% hence my concern.

I like how Adam breaks apart the molecule and looks for possible dangers at a deeper level, this is exactly the kind of research we need when determining true safety.

Nobody is going to use concentrations nearing 12 - 15%!

Hell wrote 12.5% by accident. Its 1.25% he is using.

[hellouser]

Nobody is going to use concentrations nearing 12 - 15%!

Hell wrote 12.5% by accident. Its 1.25%!

5% is probably the max needed. Cosmo got results at 1% that were the same when at 5%.

[yan]

5% is probably the max needed. Cosmo got results at 1% that were the same when at 5%.

Exactly my thoughts.

[UK_]

Well in that case I think I'm going to place an order.

It's the only option I have... I cant stand finasteride... it for some reason makes me numb to sexual pleasure... which I'd rather be bald than lose sexual pleasure (seriously you dont know what you've got till its gone).

But the most weird side effect is that it numbs my desire to seek out and "chase" the opposite sex, that's a horrid side effect that leaves you wondering... "whats the point in living?".

[yan]

Well in that case I think I'm going to place an order.

It's the only option I have... I cant stand finasteride... it for some reason makes me numb to sexual pleasure... which I'd rather be bald than lose sexual pleasure (seriously you dont know what you've got till its gone).

But the most weird side effect is that it numbs my desire to seek out and "chase" the opposite sex, that's a horrid side effect that leaves you wondering... "whats the point in living?".

Haha I know that feeling exactly. When I was on 1mg / day I was like "I dont care about women at all".