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I've got a question about Replicel! This one is particularly an interesting one.
Since Replicel's initial results were disappointing for the forum members here, has anyone thought more about WHY there wasn't more hair beyond the regular gum flapping responses like 'it doesnt work! waah!'
Consider this; when a baby is born, hair on it is very thin. Its only had 9 months in the womb to develop and even in the coming months after birth the baby still does not show dense hair. I would say a human's head is most full with hair during the ages of 8-14 and then things go south, at least for men since women are lucky.
So!
Replicel took a bunch of DSC cells, multiplied them and injected them back into the scalp underneath the skin. After 6 months we saw 15% more terminal hair. But did anyone take into account that perhaps during that 6 month time frame the DSC cells may have needed time to form into a complete hair follicle?
Basically, the question is; are we really expecting those DSC cells to tranform into follicles overnight? Over weeks? Or months? And even then, can we not take into account anagen, catagen and telegen cycles before it reaches its FULL potential?
Consider this, that standard FUE/FUT and even HST transplants require a minimum of 6 months before results are seen and even then things can take longer to develop.
Are we not jumping the gun a little?
Shiseido did just dump millions of dollars on Replicel. A lot of people are saying '...replicel doesn't work unless Shiseido knows something we don't'. Obviously, they do know something we don't, but is it what we're hoping for? Perhaps the extra time was enough to make a convincing case for Shiseido and the results we're better than the 6 month mark we were shown?
Lets even assume that those results are the best they could achieve. We're still however leaving out the possibility of using Replicel in combination of Finasteride to inhibit DHT and Minoxidil as a growth stimulant. Perhaps wounding + minoxidil would cause a chain reaction of results given that when minoxidil was applied, PGE2 levels were raised which could turn those DSC cells into complete follicles and possibly from raised levels of FGF9? And this isn't even taking into consideration Histogen's own growth factors!
So... thoughts? I have a feeling Desmond could chime in on this.
Since Replicel's initial results were disappointing for the forum members here, has anyone thought more about WHY there wasn't more hair beyond the regular gum flapping responses like 'it doesnt work! waah!'
Consider this; when a baby is born, hair on it is very thin. Its only had 9 months in the womb to develop and even in the coming months after birth the baby still does not show dense hair. I would say a human's head is most full with hair during the ages of 8-14 and then things go south, at least for men since women are lucky.
So!
Replicel took a bunch of DSC cells, multiplied them and injected them back into the scalp underneath the skin. After 6 months we saw 15% more terminal hair. But did anyone take into account that perhaps during that 6 month time frame the DSC cells may have needed time to form into a complete hair follicle?
Basically, the question is; are we really expecting those DSC cells to tranform into follicles overnight? Over weeks? Or months? And even then, can we not take into account anagen, catagen and telegen cycles before it reaches its FULL potential?
Consider this, that standard FUE/FUT and even HST transplants require a minimum of 6 months before results are seen and even then things can take longer to develop.
Are we not jumping the gun a little?
Shiseido did just dump millions of dollars on Replicel. A lot of people are saying '...replicel doesn't work unless Shiseido knows something we don't'. Obviously, they do know something we don't, but is it what we're hoping for? Perhaps the extra time was enough to make a convincing case for Shiseido and the results we're better than the 6 month mark we were shown?
Lets even assume that those results are the best they could achieve. We're still however leaving out the possibility of using Replicel in combination of Finasteride to inhibit DHT and Minoxidil as a growth stimulant. Perhaps wounding + minoxidil would cause a chain reaction of results given that when minoxidil was applied, PGE2 levels were raised which could turn those DSC cells into complete follicles and possibly from raised levels of FGF9? And this isn't even taking into consideration Histogen's own growth factors!
So... thoughts? I have a feeling Desmond could chime in on this.
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