Has Anybody Used PGD2 Blockers for 4+ Months and KEPT Balding??

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  • ar50
    Senior Member
    • May 2013
    • 115

    #31
    hey guys.

    I read about different medicines. I was off line for a few days. which of the medicines works? Im sorry for the questions but I am not so experienced as you guys.
    So does CB and pdg2 work?

    Comment

    • justeone
      Member
      • Nov 2011
      • 54

      #32
      Looking forward to seeing some evidence of Pgd2 blockers working at halting hair loss. Would be great to keep what I have now and worry about the hairline after. Conpecia let us know how it goes!

      Comment

      • Avacfc
        Member
        • May 2013
        • 31

        #33
        I used cet for about 6 months when the guys on *** also started. Looking back It was deffo the best thing I have used other than fin, however I stupidly got complacent and stopped over time. I now plan to restart along with 2% ru and minox hopefully this will cover a fair few pathways.

        Comment

        • hiilikeyourbeard
          Senior Member
          • Jun 2013
          • 138

          #34
          ITT: a bunch of balding men rubbing allergy pills on their heads

          but really, is that kind of the gist of it? what vehicle is best? i'm willing to give this a shot along with ru

          Comment

          • chimera
            Senior Member
            • Aug 2012
            • 171

            #35
            There is something wich makes me feel uneasy about the whole cet thing. Most of the guys on *** who used it (even those who said it was working for them) were (or still are, I'm not sure) mixing cet with... ¡water!... now that's something I just can't believe, how can water work as a vehicle for cet? that's just... weird...

            Comment

            • Pentarou
              Senior Member
              • Apr 2013
              • 482

              #36
              Correct me if I'm wrong, but isn't the whole PGD2 = male pattern hair loss explanation remain an unproven theory (hypothesis?) based on studies on mice?

              Comment

              • chimera
                Senior Member
                • Aug 2012
                • 171

                #37
                Well, PGD2 was proven to inhibit hair growth on mice and also in human, in-vitro and in-vivo. In fact, the PGD2 theory helps to understand a little more the whole process (including the role of DHT)

                Comment

                • Conpecia
                  Senior Member
                  • Sep 2011
                  • 904

                  #38
                  You're right. Only evidence besides that is about 20 or so forum baldies who have claimed to stop their hairloss with either CET or I/C combo. Horrible for those obsessed with data but for those who can rely on mere logic it seems pretty convincing that two completely different products have allegedly stopped hair loss, and the only similarity is pgd2 inhibition... Again, take finasteride if you can. I can't. Therefore on to this stuff.

                  Actually, isn't there a pgd2 study on human mpb too? Proving bald men have higher pgd2 and lower pge2 and pgf2? Someone dig it up...

                  Comment

                  • clandestine
                    Senior Member
                    • Aug 2011
                    • 2002

                    #39
                    Con are you on both cet and indo/chromo?

                    Comment

                    • Conpecia
                      Senior Member
                      • Sep 2011
                      • 904

                      #40
                      Nope just the latter, Regenepure, and Rogaine foam

                      Comment

                      • thechamp
                        Senior Member
                        • Jan 2011
                        • 1763

                        #41
                        Originally posted by Conpecia
                        You're right. Only evidence besides that is about 20 or so forum baldies who have claimed to stop their hairloss with either CET or I/C combo. Horrible for those obsessed with data but for those who can rely on mere logic it seems pretty convincing that two completely different products have allegedly stopped hair loss, and the only similarity is pgd2 inhibition... Again, take finasteride if you can. I can't. Therefore on to this stuff.

                        Actually, isn't there a pgd2 study on human mpb too? Proving bald men have higher pgd2 and lower pge2 and pgf2? Someone dig it up...
                        Conpecia how exciting is the cet treatment do you think the guys that have been on it 6 months could expect any more regrowth?

                        Comment

                        • chimera
                          Senior Member
                          • Aug 2012
                          • 171

                          #42
                          Originally posted by Conpecia
                          Actually, isn't there a pgd2 study on human mpb too? Proving bald men have higher pgd2 and lower pge2 and pgf2? Someone dig it up...
                          Yeah, the cotsarelis study released last year also included human data, not just mice.

                          Originally posted by Conpecia
                          Nope just the latter, Regenepure, and Rogaine foam
                          Up to this point, we still don't know if chromo or indo really help against hair loss, there is still no real proof. But, assuming they do work the way we think they do, I really think that chromo won't do much for you (I hope I'm wrong). I think that indo is the real deal, not the chromo. Chromo may help a little, as it is a mast cell stabilizer, but it is said that not all the PGD2 that affects the follicle comes from the mast cells. Indo should work way better, as it work through two different routes. First, it inhibits COX, reducing then both prostaglandines (the good ones and the bad ones), but it is also supposed to be a PGD2 antagonist (yeah, in paper indomethacin is a PGD2 agonist, but in the practice it is supposed to work more like a antagonist than an agonist).

                          Still, as I said, I hope I'm wrong and chromo helps you, good luck

                          Comment

                          • Conpecia
                            Senior Member
                            • Sep 2011
                            • 904

                            #43
                            Originally posted by thechamp
                            Conpecia how exciting is the cet treatment do you think the guys that have been on it 6 months could expect any more regrowth?
                            I don't think so man. It's purely for stopping loss so far. That's why I think guys like Desmond would help us out in a major way by suggesting some experimental regrowth combinations that go along with this theory.


                            Listen though: you need to stop your loss no matter where you are in NW territory. I think we are on the cusp of a major advancement in the HT industry, by 2015 there may be 100 percent donor regeneration and zero scarring with bigger yields. So stop your hairloss now then worry about regrowth.

                            Comment

                            • Conpecia
                              Senior Member
                              • Sep 2011
                              • 904

                              #44
                              Originally posted by chimera
                              Yeah, the cotsarelis study released last year also included human data, not just mice.



                              Up to this point, we still don't know if chromo or indo really help against hair loss, there is still no real proof. But, assuming they do work the way we think they do, I really think that chromo won't do much for you (I hope I'm wrong). I think that indo is the real deal, not the chromo. Chromo may help a little, as it is a mast cell stabilizer, but it is said that not all the PGD2 that affects the follicle comes from the mast cells. Indo should work way better, as it work through two different routes. First, it inhibits COX, reducing then both prostaglandines (the good ones and the bad ones), but it is also supposed to be a PGD2 antagonist (yeah, in paper indomethacin is a PGD2 agonist, but in the practice it is supposed to work more like a antagonist than an agonist).

                              Still, as I said, I hope I'm wrong and chromo helps you, good luck
                              I agree. But I'm not gonna risk dropping chromo until others can verify that. Right now we're all at the point where there is confidence that I/C stops loss. If people start dropping chromo and keep results then indo will be the key.

                              Comment

                              • thechamp
                                Senior Member
                                • Jan 2011
                                • 1763

                                #45
                                Originally posted by Conpecia
                                I don't think so man. It's purely for stopping loss so far. That's why I think guys like Desmond would help us out in a major way by suggesting some experimental regrowth combinations that go along with this theory.


                                Listen though: you need to stop your loss no matter where you are in NW territory. I think we are on the cusp of a major advancement in the HT industry, by 2015 there may be 100 percent donor regeneration and zero scarring with bigger yields. So stop your hairloss now then worry about regrowth.
                                I need instruction for cet topical do I use minoxdil seperate?

                                Comment

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