Tweet
And that's a thing that I never understood, peoples realize that they're losing their hair only at the moment when they have the temples of Vegeta.. or a big asteroid crater in the vertex spot...
-
-
guys enlighten the balding sufferers , where we get this indo chrono thing? any more info about it?Comment
-
Chromoglycate
A compound called disodium cromoglycate, or also known simply as cromoglicic acid or chromoglycate, has been shown to be highly effective in inhibiting mast cell production and release of various prostaglandins, including prostaglandin D2[1].
PGD2 and Baldness
In 2012, Garza and Cotsarelis implicated prostaglandin D2 as a primary or main causative factor in male pattern baldness (androgenic alopecia)[2]. Prostaglandin D2 is an inflammatory prostaglandin (read more here: http://www.iron-dragon.com/product_i...roducts_id=230) found throughout the body and with multiple convergent roles, including immune function, inflammation, and central nervous system functions such as sleep and circadian rhythms [3]. Prostaglandin D-synthase or PGDS is an enzyme that has been shown to convert arachidonic acid (AA) into prostaglandin (PGs).
L-PGDS vs H-PGDS
Two known types of PGDS have been discovered that are functionally convergent, meaning that they have a similar function (to convert AA into PGD2) but developed through evolutionary mechanisms independently of one another to act in separate physiological niches [4]. Lipocalin-type PGDS or L-PGDS exists primarily in the central nervous system and acts to upregulate levels of PGD2 for purposes of sleep regulation [3]. Hematopoetic-type PGDS or H-PGDS is found in the skin, blood, skeletal system, and in smooth and skeletal muscle, and is involved in immune response and inflammation [4].
Al-Waili et al write:
[it is] hypothesized that… the overproduction of PGs is responsible for immunosuppression and secondary anemia in conditions associated with increased PG synthesis, such as pathologic inflammation, malignancy, trauma, and injury, and (2) that PG inhibitors reverse immunosuppression and secondary anemia, thereby enhancing the immune response. [5]
It is unlikely that disodium cromoglycate reduces physiological L-PGDS, CNS-involved prostaglandins, or interferes with the CNS or circadian rhythm roles of PGD2.
MPB as Inflammatory/Autoimmune Disorder
H-PGDS appears to be the main or only PGDS that could potentially play a role in the generation of local prostaglandins and induce androgenic alopecia. H-PGDS acts within a specialized type of immune cell called a mast cell to convert the downstream product of arachidonic acid (PGH2) into PGD2:
PGD(2) is formed from arachidonic acid by successive enzyme reactions: oxygenation of arachidonic acid to PGH(2), a common precursor of various prostanoids, catalyzed by cyclooxygenase, and isomerization of PGH(2) to PGD(2) by PGD synthases (PGDSs). PGD(2) can be either pro- or anti-inflammatory depending on disease process and etiology[6]
Mast cells exist in red blood cells, skin, the gastrointestinal tract, and the vascular system. Functioning mast cells are part of a normal, health immune system and also play roles in wound healing, but overactive mast cells are implicated in various immunological or inflammatory disorders as well as other diseases; PGD2 is a key component in some of these conditions:
Prostaglandin (PG)D(2) is a key mediator in various inflammatory diseases including allergy and asthma. It is generated by activated mast cells after allergen exposure and subsequently orchestrates the recruitment of inflammatory cells to the tissue. PGD(2) induces the chemotaxis of Th2 cells, basophils and eosinophils, stimulates cytokine release from these cells and prolongs their survival, and might hence indirectly promote IgE production. PGD(2) mediates its biologic functions via 2 distinct G protein-coupled receptors, D-type prostanoid receptor (DP), and the chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) [7]
If Cotsarelis and Garza’s findings that PGD2 is a causative factor in human male pattern baldness are replicated, male pattern baldness may come to be regarded as an inflammatory or autoimmune disorder.
Citations
[1]Shichijo M, Inagaki N, Nakai N, Kimata M, Nakahata T, Serizawa I, Iikura Y, Saito H, Nagai H. The effects of anti-asthma drugs on mediator release from cultured human mast cells. Clin Exp Allergy. 1998 Oct;28(10):1228-36.
[2] Garza LA, Liu Y, Yang Z, Alagesan B, Lawson JA, Norberg SM, Loy DE, Zhao T, Blatt HB, Stanton DC, Carrasco L, Ahluwalia G, Fischer SM, FitzGerald GA, Cotsarelis G. Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Sci Transl Med. 2012 Mar 21;4(126):126ra34.
[3] Wei-Min Qu et al. Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. PNAS 103(47), 17949–17954. Nov 2006.
[4] Urade Y, Eguchi N. Lipocalin-type and hematopoietic prostaglandin D synthases as a novel example of functional convergence. Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:375-82.
[5] Al-Waili NS, Saloom KY, Al-Waili T, Al-Waili A, Al-Waili H. Modulation of prostaglandin activity, part 1: prostaglandin inhibition in the management of nonrheumatologic diseases: immunologic and hematologic aspects. Adv Ther. 2007 Jan-Feb;24(1):189-222.
[6] Joo M, Sadikot RT. PGD synthase and PGD2 in immune resposne (sic). Mediators Inflamm. 2012;2012:503128. Epub 2012 Jun 25.
[7]Schuligoi R, Sturm E, Luschnig P, Konya V, Philipose S, Sedej M, Waldhoer M, Peskar BA, Heinemann A. CRTH2 and D-type prostanoid receptor antagonists as novel therapeutic agents for inflammatory diseases. Pharmacology. 2010;85(6):372-82. Epub 2010 Jun 16.
Comment
-
Really dude, don't you know anything about PGD2?
About side effect, no big one reported yet in different forums, my friend didn't report side effect yet, and there is nothing worst than finastereide for young guyz, playing with your Hormone Level a this ages its like playing with the fire, Fin had totally killed my penis for a loooong time..Comment
-
Chromo/Indo is a powerful PGD2 inhibitor thats why its so efficient for stoping hairloss, but in the other hand it also inhib PGE2, and PGE2 is important for growing hairComment
-
Yeah, but my friend just got stunning results with that so i want to give it a try before ramatroban, but PGD2 blockers are definitly the way to go for all young dudesComment
-
so bibz if i apply that topical i will stop the loss and i wont need to visit the barber again?Comment
-
bibz stop trolling us man post some legit evidence this stuff STOPS loss!I'm young NW2 save me !Comment
-
lol trolling?
@Dan
Its just an advice... I'm going to order it next week, i will post pics of my temples and i will show you the evolution.
I don't really care of density cuz I have a good one, my only goal is to stop the MBP, was on propecia during 2 years, that shit totally blew my hormone level, and im on rogaine since 3 years, pretty good stuff but i'm noticing a loss of effiencyComment
-
As I said peoples dont really promote PGD2 blockers cuz i think its because they're not really efficient for regrowt hair, but its a powerful weapon for stopping the loss, and my friend told my that it stopped his loss like immediatly, so i'm going to tryComment
Comment