Dr. Cotsarelis New Discovery that may finally cure Baldness (June 3rd, 2013)

[Pentarou]

Guys, if any of you actually does this, remember to inhibit PGD2 while wounding. Garza's paper last year stated that PGD2 inhibits new follicle formation - this could have hindered Follica.

PGD2 is part of the puzzle, indeed!

"Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis through the Receptor, Gpr44"

http://www.nature.com/jid/journal/v133/n4/full/jid2012398a.html

[clandestine]

edit: well ah ***** nvm

[KO1]

Joker is not correct, it has not been tested on humans. What has been tested on humans is lithium+wounding.

[The Alchemist]

Joker is correct, this has been tested in humans. Quote from the Xconomy article:

"Follica said in its statement that it has already done preclinical tests that combine devices it has created to disrupt the skin with several unspecified “known and novel drugs.” It also claims to have run “a series” of human clinical trials, including a mid-stage study that has caused new hair follicles to be produced in humans. "

[Joker]

No sense in arguing, but TravisB is wrong. Follica stated that this approach has advanced through Phase IIa clinical testing (in humans) and has "consistently created substantial new hair follicle growth in humans."

I'm sure the treatment isn't perfect, but the theory itself has been proved in the human model and isn't limited to mice. This fgf finding makes the translation from mice to humans more likely.

I would urge people to remain extremely cautious about this, but there's no doubt that it's exciting.

Source (provided by Thinning87 on another thread):

http://www.xconomy.com/boston/2013/06/03/hair-raising-follica-study-could-point-to-baldness-therapy/

[Westonci]

Here's the article in the journal Nature medicine.

http://www.nature.com/nm/journal/vaop/ncurrent/abs/nm.3181.html

[Boldy]

Here is further discussion about it:

http://goo.gl/2eQt3

[Westonci]

Heres the official press Release

http://www.uphs.upenn.edu/news/News_Releases/2013/06/cotsarelis/?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+penn-medicine-news+%28Penn+Medicine+News%29

[Thinning87]

It's another study that was done on MICE

there is no evidence that it will even work on humans

It's not a big deal to grow hair on mice. It looks like anyone can do it these days because everything you put on mice regrows their hair.

It's similar thing as with all this PGD2 crap

Yes genius straighten these idiots from the University of Pennsylvania and UCSF out, they are clearly missing your point.

[KO1]

Guys, if any of you actually does this, remember to inhibit PGD2 while wounding. Garza's paper last year stated that PGD2 inhibits new follicle formation - this could have hindered Follica.

[TravisB]

It's another study that was done on MICE

there is no evidence that it will even work on humans

It's not a big deal to grow hair on mice. It looks like anyone can do it these days because everything you put on mice regrows their hair.

It's similar thing as with all this PGD2 crap

[Thinning87]

the article mentions that they have told the author that human trials have already been made....

[Westonci]

The only problem is that everything is tested in rats for some reason never reaches the final stage, humans.

Anyway, fingers crossed.

Its funny you mention that. Cotrsarelis actually wanted to find out why mice would form new hairs after wounding and why humans would not, and thats how he discovered Fgf9.

According to the article mice naturally have elevated levels of Fgf9 in their skin, which explains why they regenerate new hairs after wounding.

Humans on the other hand have significantly less Fgf9 in our skin, and explains why we have trouble forming new hairs after wounding.

So basically we need to externally add Fgf9 during the wounding process to create new hairs.

[JulioGP]

The only problem is that everything is tested in rats for some reason never reaches the final stage, humans.

Anyway, fingers crossed.

[Thinning87]

Huh, so Follica isn't dead afterall?

Good.

But as always, most likely nothing will come from it (at least not in the next 10 years)

right on man very useful input