Histogen's FINAL Phase I/IIa Results (2013)

[KO1]

VCs are sorely needed in this industry. We need more people to invest in startups that could bring these technologies to clinical trials....I'm just at a loss as to why more isn't invested in this, there's no shortage of balding rich men.

A big part of the problem is that there's an attitude of "nothing can be done"...

[Desmond84]

Hey guys,

I came across an article today regarding drug development and it was so spot on regarding the current situation of Histogen that I thought I should post it here:

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Challenges of Biotech

The challenges facing the biotech firms in 2013 are acute. Once viewed as a source of fresh innovation, many biotech companies with new molecules or technology platforms are struggling to access capital, and are finding it increasingly difficult to find large pharmaceutical partners willing to take
over promising products in early-phase development.

Indeed, a 2010 survey by Lazard indicated that 89% of Big Pharma execs say filling late-stage pipeline is one of the top driving forces in pharma-biotech consolidation, while only 32% chose filling early-stage pipeline as one of the top three factors.

In the wake of the global financial crises, biotech companies are caught between a risk-averse pharmaceutical industry unwilling to license products in early development, and skittish financial markets where access to capital has become increasingly challenging.

As a result, many biotech firms find themselves in the discouraging position of having met their strategic objectives of progressing a bio-asset to a pre-determined end point of pre-clinical or early clinical development, but unable to find a partner willing to complete clinical development and commercialize the product. This poses a formidable problem for the biotech industry in three important ways:

• The most expensive part of clinical development is Phase III, requiring large studies with patients enrolled over a large geographic spread. On average, for every new molecular entity (NME) that reaches registration, 90% or more of the R&D costs occur in Phases II and III. Most biotech companies do not have the financial capital to progress a compound through late stage development.
  
• The skills needed for research versus clinical development are very different. Successful biotech companies have excellent discovery platforms and scientists, but generally lack the knowledge and skills needed for clinical development and the commercial acumen to build value into their late phase studies.
  
  
• While research and discovery are a physically concentrated activity requiring limited, albeit specialized, infrastructure, clinical development is a much more expansive global process. Therefore, many biotech companies often find the challenges of product development nearly insurmountable – the need for cross-functional teams representing clinical pharmacology, medical, regulatory, clinical operations and drug safety, plus strategic marketing input and market access strategies dispersed across geographic regions as diverse as the US, Europe, Japan and China.

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Here's the link to the article:

http://www.quintiles.com/assets/0/111/118/233/1336/cb9d88e2-ff07-4316-8784-93d75b064b9b.pdf

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So, even though Histogen has a working formulation, they are facing significant challenges to find a partner to carry out the remaining trials!

So what do you guys think we could do to help them out?

Should we be writing petitions to Pfizer, Merck and other big Pharma to provide funding to Histogen!

We certainly have a strong voice! There are a lot of MPB sufferers out there and thousands alone on this single forum! Let's get the ball rolling or we'll be waiting for a very long time for Phase 2b to start!

[Thinning87]

I'm actually like you. I've got investment from both angels and VCs and 'most' of them got lucky and have money to splash around.

I'm sure Microsoft has plenty of shite unhappy VC's right now. Probably so does Apple after their latest news.

Mr Pin Stripe has nothing to offer on these boards and I'm here solely to point that out to new members that care about Histogen and the small facts that we do have.

Nobody here gives a shite about his VC blah. Or his I'm making stuff up by filling in the blanks speculation.

Its not fair for depressed newcomers, coming here to find some hope, only to read this shite and perhaps take his misinformation as gospel. The last thing we need in this world and particularly these forums are more haters. Especially newbies that read one or two threads and think they know it all.

The concept of when it's best to raise funds is not wrong in itself, but he's applying this concept in a more complex situation he evidently hasn't fully studied.

[rdawg]

God I really think people overreacted to this update. They haven't even done efficiency testing, and so far we have something that is better than propecia and practically SIDE FREE.

HSC needs to come out NOW.

haha I dont think they lowered my hopes or anything, they just didn't excite me like crazy I suppose, but i definitely want to see how their next trial goes!

the fact is this stuff works! and I want to use it when it comes out!! Barring it costing a ridiculous price that is.

[FearTheLoss]

God I really think people overreacted to this update. They haven't even done efficiency testing, and so far we have something that is better than propecia and practically SIDE FREE.

HSC needs to come out NOW.

[Kiwi]

Maybe I'm ignorant but what does VC stand for?

In these forums absolutely nothing :P

Unless you're mr big shot pin stripe speculating around what Histogen hasn't told us yet.

Well I hope that's the last we see of him unless he has something positive to offer.

[Thinning87]

Maybe I'm ignorant but what does VC stand for?

Venture capital

[garethbale]

Maybe I'm ignorant but what does VC stand for?

[ryan555]

haha - normally its the ladies that congratulate me about those (not ladies like old whats her name on the boards that always tells the boys to use fin... tracey!!!). I think she's anti erection. And now I'm just being silly.

I'm actually like you. I've got investment from both angels and VCs and 'most' of them got lucky and have money to splash around.

I'm sure Microsoft has plenty of shite unhappy VC's right now. Probably so does Apple after their latest news.

Mr Pin Stripe has nothing to offer on these boards and I'm here solely to point that out to new members that care about Histogen and the small facts that we do have.

Nobody here gives a shite about his VC blah. Or his I'm making stuff up by filling in the blanks speculation.

Its not fair for depressed newcomers, coming here to find some hope, only to read this shite and perhaps take his misinformation as gospel. The last thing we need in this world and particularly these forums are more haters. Especially newbies that read one or two threads and think they know it all.

They were useful in the 90's when entrepreneurs could convince them that their free smiley download website with neither revenue nor a business plan was worth $100 million.

[Kiwi]

Not denying a thing, nor do I want to check what's going on in your pants to confirm. Congratulations on your erections, by the way.

haha - normally its the ladies that congratulate me about those (not ladies like old whats her name on the boards that always tells the boys to use fin... tracey!!!). I think she's anti erection. And now I'm just being silly.

I'm actually like you. I've got investment from both angels and VCs and 'most' of them got lucky and have money to splash around.

I'm sure Microsoft has plenty of shite unhappy VC's right now. Probably so does Apple after their latest news.

Mr Pin Stripe has nothing to offer on these boards and I'm here solely to point that out to new members that care about Histogen and the small facts that we do have.

Nobody here gives a shite about his VC blah. Or his I'm making stuff up by filling in the blanks speculation.

Its not fair for depressed newcomers, coming here to find some hope, only to read this shite and perhaps take his misinformation as gospel. The last thing we need in this world and particularly these forums are more haters. Especially newbies that read one or two threads and think they know it all.

[clandestine]

ryan come and check out my fin induced gynecomastia dude, I'll show you "persistent side effects".

[ryan555]

So you're not denying I lost my erections but I did manage to get them back

Not denying a thing, nor do I want to check what's going on in your pants to confirm. Congratulations on your erections, by the way.

[ryan555]

Why are you guys arguing with this dude. I am an entrepreneur and had to deal with VC's early on before I had legitimate investors (private equity) buy me out. VC's are some of the dumbest and most arrogant people you will ever meet. It's better to just tell them they're right and then laugh at them when they walk out of the room.

[Kiwi]

I didn't say there weren't side effects, I said they're greatly blown out of proportion. There are studies like the Japanese one posted in some other thread in here that showed lower incidence of side effects for guys on a low dose of propecia than guys on a placebo. No matter who studies this, no one seems to be able to reproduce either long term persistent side effects or side effect rates over about 2%. And yet magically, when you go online, more like half of the guys taking it claim to have terrible side effects. Meanwhile, loads of young guys are reading this and going bald, spending their lives obsessing and hanging out talking to whackos on hair loss forums.

So you're not denying I lost my erections but I did manage to get them back

[Kiwi]

Unfortunately straw man and wishful thinking do not make for a compelling counter to my concerns/questions. You appear far removed from the real world. Good luck with Histogen. And I mean that.

In the VC world, there is an old saying "Evaluate on what they do, not what they say". The course of action Histogen has taken leading up to their result dissemination speaks louder than the results themselves. For an outsider/forum hopeful like yourself, it will be time that will have to prove me right.

More blah. Thanks mr big VC man. So what big vc deals that we all know about have you been directly responsible for?

Your contribution to this thread and forum is what is removed. My information is based on what I've read from Histogen.

NOT based on what they haven't said 'oh wow I can say big words like VC so now Im an authority on Histogen and can fill in the blanks for them'.

Also are you a chemical / pharmaceutical scientist as well as a pin stripe VC big wig? Just wondering.