Complete RU58841 Usage Guide

[diffuseloser]

The way I interpret this is that this new "ROS" RU in raw powder form, will remain stable for 1 year at room temperature and the premixed RU in KB solution for 6 months. It doesn't mean that KB solution is necessary to keep it stable. This is quite an achievement and I have no idea how they've managed to do this but it's positive for us as it basically elimates the need to store RU in fridge/freezer. Personally, I'll still be storing mine in the fridge for peace of mind. Perhaps Kane/Anageninc found it necessary to find a way to prolong the lifespan of useable RU due to issues with customs. I don't care either way as long as it works. I'll be mixing mine with a small amount of isopropyl to dissolve the RU and then dump it into minoxidil and see how it goes for a few months.

[doke]

what I said kb solution has preservers in it im not sure about there ready mixed non kb though I think kb maybe what rousell used in the trials.
There was remember trials of the ru588412 myristate as well which was supposed to be better than non myristate ru?

[diffuseloser]

I'm not 100% sure mate. I'm fairly new to all this and just trying to apply the knowledge gained on these forums. Gonna give it a go with minoxidil as I'm already having fairly decent maintenance with minoxidil alone, so putting some RU in the mix can't hurt. There's so many variables, it's overwhelming. I'll give KB solution a go in the next batch I order.

[Boldy]

RU itself should be stable in ethanol. K&B was just designed to minimize sideffects if im not mistaken.

I have found a way to get rid of the most sides. I'm currently 2 weeks on about 0.9- 1.2% ru in a modified vehicle that should go less systematic. and experimenting with K&B with extra water.

I hope to maintain and get some thickening with this dose.

[Hairismylife]

RU itself should be stable in ethanol. K&B was just designed to minimize sideffects if im not mistaken.

I have found a way to get rid of the most sides. I'm currently 2 weeks on about 0.9- 1.2% ru in a modified vehicle that should go less systematic. and experimenting with K&B with extra water.

I hope to maintain and get some thickening with this dose.

Isn't 0.9~1.2% a too low dosage to work?

[Boldy]

Isn't 0.9~1.2% a too low dosage to work?

there are some cases on other forum where people have maintenance + bit thickening with 1% dose. for me it is too early to tell if it is working but I can tell that there is less sebum and no itching which is positive. I'm using ru only on the hairline though.

[Hairismylife]

there are some cases on other forum where people have maintenance + bit thickening with 1% dose. for me it is too early to tell if it is working but I can tell that there is less sebum and no itching which is positive. I'm using ru only on the hairline though.

I know somebody use 10%,not necessary I think.
But I will start at 2%

[Boldy]

i have been using 3 ml last couple days which is equal to about 30 mg or 3% without sides or problems. my vehicle is 50% ethanol, 25% water and 25% glycerin, so less ethanol than the average person is using.

if you have a 3-5 % solution and you have sides, what you can do is dilute it with water+ pg or glycerin.

Ru58841 has a pretty short halflife in the plasma (about 1 hour) which in can be even further reduced by taking P450 enzyme inducers. a good natural candidate which is St john's wort.

St John's wort (Hypericum perforatum) has been one of the most commonly used herbal remedies for mood disorders [1], and is also well-known as a potent inducer of cytochrome P450 (CYP) 3A [2–5]. A great number of studies have demonstrated the potential reduction in drug efficacy due to the decrement of plasma drug concentrations during the period of concomitant use of St John's wort [6, 7].

it does exactly the opposite of grapefruit juce, which inhibit the p450 liver enzyemes.


we use topicals to directly target the receptors in the dermal papilla. the hair root is a great peneration pathway along with a good penetration enhancer which the most toppicals have (ethanol).

However depending on the vehicle, your skin type, sebum production and the molecule size, some % of the drug will go systematic and will cause an effect where you don't want it. often seen as side-effect. something we want as less as possible.

here is a study that shows that plasma drug clearance was achieved 50% faster with addition of st-johns wort.

http://www.ncbi.nlm.nih.gov/pubmed/13129991

A 2-fold decrease in the area under the curve for alprazolam plasma concentration vs time (P<.001) and a 2-fold increase in alprazolam clearance (P<.001) were observed following St John's wort administration. Alprazolam elimination half-life was shortened from a mean (SD) of 12.4 (3.9) hours to 6.0 (2.4) hours (P<.001). The mean (SD) urinary ratio of dextromethorphan to its metabolite was 0.006 (0.010) at baseline and 0.014 (0.025) after St John's wort administration (P =.26).

CONCLUSIONS:
A 14-day course of St John's wort administration significantly induced the activity of CYP 3A4 as measured by changes in alprazolam pharmacokinetics. This suggests that long-term administration of St John's wort may result in diminished clinical effectiveness or increased dosage requirements for all CYP 3A4 substrates, which represent at least 50% of all marketed medications.

t St. John’s wort
induced P-gp, a drug transporter protein.
Co-administration of St. John’s wort also
markedly induced human CYP3A4,
CYP2E1 and CYP2C19 whereas it had no
appreciable effect on CYP1A2, CYP2C9
and CYP2D6

Now I'm not 100% sure yet if ru is metabolized via cyp3a4, CYP2E1 and CYP2C19, but I will find out the coming weeks

[Kudu]

Thanks for posting this Boldy, very interesting. Definitely something to read up on.

[Kudu]

Guys, does kane accept paypal for RU? If not, how do you wire money via western union? I'm running out of time, I'll probably be a NW 4 within 6 months.

[diffuseloser]

Isn't RU insoluble in water Boldy? Just got my latest batch of RU from Kane and it states this on the packing slip. Made up my solution this evening and it was dead easy as I don't have to worry about RU degrading anymore. Simply dumped all 5grams of RU in a measuring jug and covered it with just enough isopropyl. Then dumped in 60ml Kirkland minoxidil. Put the covered measuring jug in the sink and filled it with hot water. Dissolved completely in under an hour with some stirring and not a crystal in sight. Then just filled up an empty Kirkland bottle with the solution. I'm good to go for a month or more. Wish me luck.

[diffuseloser]

Kudu, Kane now accepting PayPal.

[Boldy]

Isn't RU insoluble in water Boldy? Just got my latest batch of RU from Kane and it states this on the packing slip. Made up my solution this evening and it was dead easy as I don't have to worry about RU degrading anymore. Simply dumped all 5grams of RU in a measuring jug and covered it with just enough isopropyl. Then dumped in 60ml Kirkland minoxidil. Put the covered measuring jug in the sink and filled it with hot water. Dissolved completely in under an hour with some stirring and not a crystal in sight. Then just filled up an empty Kirkland bottle with the solution. I'm good to go for a month or more. Wish me luck.

No, at-least not here. when i go under the 35% ethanol the solution becomes cloudy.

[Kudu]

Kudu, Kane now accepting PayPal.

Thanks man, so you order through PayPal without any issues? Just checking because I plan on ordering later today.

[diffuseloser]

Well I had a problem with customs with my last order but all you gotta do is contact Kane and he will send you another batch out right away. RU is no longer a nightmare to prepare either. How many grams are you ordering and what vehicle are you planning to use buddy?