A case of NW7 for in-vivo Doubling / HM / DP - Day 1 @ Dr. Nigam's

**gc83uk** · 04-15-2013, 05:23 PM

Originally posted by HARIRI

I know the In-vivo method is better but I need the In-vitro as it will be for my scar so roots are needed. In-vivo is a new technique for Dr. Nigam as he recently has an ultrasound and imaging so he does not need to go deep without the need of removing the graft however invitro have to go deep like fue and remove the whole graft. In-vitro is outdated for Dr. Nigam but still need to be used for scars.

Why does it need to be used for scars? Are you saying the in-vivo won't work in scar tissue?

**gc83uk** · 04-15-2013, 05:26 PM

Originally posted by Ted

Good Luck Hariri!
Can someone please describe the difference between the in-vivo and in-vitro
technique?

As far as I understand Ted, the in-vivo is basically extracting a part of the graft and implanting that part in the recipient area. The donor are will regenerate the part of the graft that was left in there from the start.

In-vitro, the whole graft is extracted from the donor... And it is bisected outside the scalp which is meant to give better results as the dr can bisect the graft easier under a microscope with out any errors (transections). You can either place both of these 2 parts of the graft in to the recipient or place 1 part back where you extracted it from and 1 in the recipient. This is how I understand it.

**Joker** · 04-15-2013, 05:58 PM

GC, can you comment on the NSN/IM/Dr. Nigam craziness?

No one involved speaks coherent English and I have no idea what's going on.

Don't mean to drag you into this since I'm sure you're pretty far removed from the situation, but I was pretty disheartened to learn that there would be absolutely no more updates from NSN and no solid reason was offered.

Feel free to respond on another thread so that this one isn't ruined.

**gc83uk** · 04-15-2013, 06:11 PM

Originally posted by Joker

GC, can you comment on the NSN/IM/Dr. Nigam craziness?

No one involved speaks coherent English and I have no idea what's going on.

Don't mean to drag you into this since I'm sure you're pretty far removed from the situation, but I was pretty disheartened to learn that there would be absolutely no more updates from NSN and no solid reason was offered.

Feel free to respond on another thread so that this one isn't ruined.

I'm pretty sure we'll have an update from NSN in good time. It might be that he wants to wait a few months to see the full result, anything else is just speculation imo.

As for Dr Nigam. He is definitely not orthodox and has made some terrible mistakes. However whilst there seems to be plenty of volunteers wanting to guinea pigs on this very forum, we will know whether this works or not for sure in the next few weeks/months, which is exciting in itself!

**The Alchemist** · 04-15-2013, 09:27 PM

Originally posted by gc83uk

However whilst there seems to be plenty of volunteers wanting to guinea pigs on this very forum, we will know whether this works or not for sure in the next few weeks/months, which is exciting in itself!

Ha! I wouldn't hold my breath waiting for that. I believe that was said when OBI went for his treatment, and then again when Neversayneverexceptifyourpostingphotos had his treatment. And We're still not clear on it. I hope it happens but won't be a bit surprised if in a few months this is as clear as mud.

**drnigams** · 04-15-2013, 10:25 PM

GC,your explanation was absolutely correct regarding invitro/invivo doubling.
GC,
As you are aware that the anatomy of a scar tissue is somewhat different from the normal skin.When i bisect a graft inside the scalp,i do not get the root of the follicle to implant at the scalp.
When i bisect the follicle outside the scalp,i get access to the root of the follicle to implant in the scar tissue.
When a follicle is bisected, the bisected part with root has higher chances of regen than the other bisected part of the follicle.
Hence invitro or outside body bisection will be preferred
As hariri prefer approx 500 g from under the chin(beard),which is correct as beard follicle is thicker,dht resistant and few other characteristics to be called a superior follicle to implant at the scar
There is no point in strip scar revision,although some scar tissue can be excised but the scar will have a risk to stretchout again over a period of time.Total 18.6sqcms scar area he wants to cover.we will see from where do we decide to take rest of the grafts for scar implantation.

Originally posted by gc83uk

Why does it need to be used for scars? Are you saying the in-vivo won't work in scar tissue?

**HARIRI** · 04-15-2013, 11:13 PM

Originally posted by drnigams

When i bisect the follicle outside the scalp,i get access to the root of the follicle to implant in the scar tissue.
When a follicle is bisected, the bisected part with root has higher chances of regen than the other bisected part of the follicle.
Hence invitro or outside body bisection will be preferred
As hariri prefer approx 500 g from under the chin(beard),which is correct as beard follicle is thicker,dht resistant and few other characteristics to be called a superior follicle to implant at the scar
There is no point in strip scar revision,although some scar tissue can be excised but the scar will have a risk to stretchout again over a period of time.Total 18.6sqcms scar area he wants to cover.we will see from where do we decide to take rest of the grafts for scar implantation.

I remember Dr. Bisanga once told me that I need 800 beard grafts to cover my scar, so a 500 grafts extracted from under my chin with Dr. Nigam will give me around 1000 which is more than enough to cover my scar without losing this much valuable grafts which I'm preserving for my crown one day if technologies like Aderans and Histogen didn't work. I dont have the guts to slice my head again. I may go to Feriduni for hairline work by removing the low grafts and place them into my weak side of Rahal's hairline but wont risk a strip scar revision. Thanks Dr. Nigam.

**bananana** · 04-16-2013, 02:50 AM

Dr Nigam,

sorry for invading the thread - but I want to ask you something - what do you think how will histogens product interact with your HM? Do you have enough information about histogen to know the answer? What would happen if someone took both procedures?

Thank you

**drnigams** · 04-16-2013, 03:22 AM

banana,
Whatever i know as per the details provided by them at the last press conference and their clinical trials update with FDA,they use the same method to isolate and multiply stemcells with serum free media ,including the growth factors,number of passages etc.
Technically i don't see any major difference between aderans and my HM solution for injections.Yes their delivery injection is different.
I have recently started adding dp cells an dp culture with my hm injection.
I am not aware have they started the dp culture injections in their trials.
I will discuss the same with their representative if they happen to be their at 7th world congress on hair research at edinburgh on 4/5/6th may2013.
We can confirm the same when they are available in the market ,when the complete procedure of preparation of autologous stemcell solution by aderans will be known to us.

Originally posted by bananana

Dr Nigam,

sorry for invading the thread - but I want to ask you something - what do you think how will histogens product interact with your HM? Do you have enough information about histogen to know the answer? What would happen if someone took both procedures?

Thank you

**bananana** · 04-16-2013, 05:33 AM

Thanks for the answer Dr Nigam, I was wondering also about histogen? Do you know how similar their procedure is to yours?

Basically, (as far as we know), a patient could take all 3 procedures (or 2) without serious side effects?

Of course, we do not know yet how good do they work or are they compoundable, but combining them might prove efficient.

Just a thought.

**Ted** · 04-16-2013, 10:07 AM

Dr. Nigam,

Desmond84 wrote this in another thread:
"Just to be accurate too, Histogen and Aderans presentations are actually at the International Investigative Dermatology Conference which begins after the World Congress ends (From May 8 – May 11), which is held at the same venue in Edinburgh."

**drnigams** · 04-16-2013, 11:36 AM

TED,
I will attend IIDC on 8th may,after the7th world hair research congress on 4th ,5th and 6th May.
My visit to uk is from 4th may to 9th may.

Originally posted by Ted

Dr. Nigam,

Desmond84 wrote this in another thread:
"Just to be accurate too, Histogen and Aderans presentations are actually at the International Investigative Dermatology Conference which begins after the World Congress ends (From May 8 – May 11), which is held at the same venue in Edinburgh."

**drnigams** · 04-17-2013, 10:19 AM

Day-7, Donor Regen & Recep 4417 G Doubing on NW6/7@Dr.Nigam's

Day-7, Donor Regen & Recep 4417 G Doubing on NW6/7@Dr.Nigam's

A case of NW6 (NW7, as per the donor availability and the thin hairs), we plan to make him NW2 with donor doubling, stem cell, DP cell injections. At present we have done donor doubling of 4417 G. In next 3 days we will be doing more 3000 G, 1000 G each day, which brings the total of 7417 G and the same procedure will be repeated after 6 weeks when the patient will return from Malaysia.

Recipient

Please find below the Day 0 & Day 7 pictures. Today we have done 1495 G by plucked hair transplant without using any hollow needle from donor area.
You can see the quick healing & fading away of the marks.

Next step:

We will be doing Donor Doubling for next 3 days, 1000 grafts each day by plucking method.

click below link to see enlarged close up of the above pic

http://www.drnigams.net/images/MS/Day7/Large/1.jpg